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37篇 您的检索式：作者名="Xiaobin L"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Isolation and characterization of a high H2-producing strain Klebsiella oxytoca HP1 from a hot spring显示文摘	Minnan L Jinli H Xiaobin W	2005	Res Microbiol2005，156，2：	1
3	Is damage control orthope- dics essential for the management of bilateral femoral fiacturcs asso- ciated or complicated with shock7 An animal study显示文摘	Tiansheng S Xiaobin C Zhi L	2009	J Trauma2009，67，6：	1
4	The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘	Xiaobin F Zipei L Shugno Z et a1	2009	Med Hypotheses2009，72，4：	1
5	Transient receptor po- tential canonical-3 channel-dependent fibroblast regulation in atri- al fibrillation显示文摘	Masahide H Xiaobin L Xiao YQ	2012	Circulation2012，126，17：	1
6	The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘	Xiaobin F Zipei L Shugno Z et a1	2009	Med Hypotheses2009，72，4：	1
7	The pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘	XIAOBIN F ZIPEI L SHUGUO Z	2009	Med Hypotheses2009，72，4：	1
8	The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘	Xiaobin F Zipei L Shuguo Z	2009	Med Hypotheses2009，72，4：	1
9	Dynamic-thermal effects in thin film media 显示文摘	H Neal Bertram Xiaobin Wang Vladimir L Saftmov	2001	IEEE Trans 20012001，37，4：	1
10	Is damage control orthopedics essential for the management of bilateral femoral fractures associated or complicated with shock?An animal study显示文摘	Tiansheng S Xiaobin C Zhi L	2009	J Trauma2009，67，6：	1
11	The Pringle manoeu-vre should be avoided in hepatectomy for cancer patientsdue to its side effects on tumor recurrence and worseprognosis显示文摘	Xiaobin F Zipei L Shuguo Z	2009	Med Hypotheses2009，72，4：	1
12	Isolation and characterization of a high H2-producing strain Klebsialle oxytoca HPl from a hot spring显示文摘	Minnan L Jinli H Xiaobin W	2005	Res Microbiol2005，156，：	1
13	Isolation and characterization of a high H2-producing bacteria Klebsiella oxytoca HP1 from a hot spring显示文摘	Minnan L Jinli H Xiaobin W	2005	Research in microbiology2005，156，2：	1
14	The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘	Xiaobin F Zipei L Shuguo Z	2009	Med Hypotheses2009，72，4：	1
15	Dynamic-Thermal Effects in Thin Film Media 显示文摘	Bertram H N Wang Xiaobin Safonov V L	2001	Journal of IEEE2001，37，4：	1
16	Is damage control orthopedics essential for the management of bilateral femoral fractures associated or complicated with shock An animal study显示文摘	Tiansheng S Xiaobin C Zhi L	2009	J Trauma2009，67，6：	1
17	The Pringle manoeuvre Should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘	Xiaobin F Zipei L Shugno Z	2009	Med Hypotheses2009，72，4：	1
18	Spectral clustering based on matrix perturbation theory显示文摘	T Zheng L Xiaobin J Yanwen	2007	Science in China Series F Information Science2007，50，1：	1
19	Multiscale stochastic hierachical image segmentation by spectral clustering显示文摘	L Xiaobin T Zheng	2007	Science in China Series F Information Science2007，50，2：	1
20	Is damage control orthope- dics essential for the management of bilateral femoral fractures asso- ciated or complicated with Shock? An Animal Study显示文摘	Tiansheng S Xiaobin C Zhi L	2009	J Trauma2009，67，6：	1

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