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| 1 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 2 | Identification of genes contributing to quantitative disease resistance in rice显示文摘Despite the importance of quantitative disease resistance during a plant’s life, little is known about the molecular basis of this type of host-pathogen interaction, because most of the genes underlying resistance quantitative trait loci (QTLs) are unknown. To identify genes contributing to resistance QTLs in rice, we analyzed the colocalization of a set of characterized rice defense-responsive genes and resistance QTLs against different pathogens. We also examined the expression patterns of these genes in response to pathogen infection in the parents of the mapping populations, based on the strategy of validation and functional analysis of the QTLs. The results suggest that defense-responsive genes are important resources of resistance QTLs in rice. OsWRKY45-1 is the gene contributing to a major resistance QTL.NRR,OsGH3-1,and OsGLP members on chromosome 8 contribute alone or collectively to different minor resistance QTLs. These genes function in a basal resistance pathway or in major disease resistance gene-mediated race-specific pathways. | KOU YanJun, LI XiangHua, XIAO JingHua & WANG ShiPing National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research (Wuhan),Huazhong Agricultural University, Wuhan 430070, China | 2010 | Science China(Life Sciences)2010，53，11： | 6 |
| 3 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 4 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 5 | Comparison of winter wheat yield sensitivity to climate variables under irrigated and rain-fed conditions显示文摘庄稼模拟模型提供决定庄稼产量的敏感到气候变化的其他、不太费时间、划算的工具。在这研究,二个动态机械学的模型,谷神星(庄稼环境资源合成)和 APSIM (农业生产系统模拟器),被用来在灌溉的井( CFG )下面模仿小麦( Triticum aestivum L.)的收益并且喂雨( YY )在北方中国平原( NCP )在与不同气候变量的关系调节。学习测试了冬季小麦收益敏感到温度,放射,降水,和大气的二氧化碳的不同层次(在在在 NCP 的 Luancheng Agro 生态系统试验性的车站的 CFG 和 YY 条件下面的公司 2) 集中。从 CERES 和 APSIM 小麦庄稼模型的结果大部分是一致的并且建议在气候变量的变化在 NCP 影响了小麦谷物产量。也在到在不同的水(CFG 和 YY ) 下面的气候变量的产量调节的冬季小麦的敏感有重要变化。当时 2 湩漠桴牥瀠潥汰 e 的温度增加? | Dengpan XIAO Yanjun SHEN He ZHANG Juana P. MOIWO Yongqing QI Rende WANG Hongwei PEI Yucui ZHANG Huitao SHEN | 2016 | Frontiers of Earth Science2016，10，3： | 4 |
| 6 | Mechanistic-empirical pavement design guide(MEPDG):a bird's-eye view显示文摘Past editions of the American Association of State Highway and Transportation Officials(AASHTO) Guide for Design of Pavement Structures have served well for several decades;nevertheless,many serious limitations exist for their continued use as the nation's primary pavement design procedures.Researchers are now incorporating the latest advances in pavement design into the new Mechanistic-Empirical Pavement Design Guide(MEPDG),developed under the National Cooperative Highway Research Program(NCHRP) 1-37A project and adopted and published by AASHTO.The MEPDG procedure offers several dramatic improvements over the current pavement design guide and presents a new paradigm in the way pavement design is performed.However,MEPDG is substantially more complex than the AASHTO Design Guide by considering the input parameters that influence pavement performance,including traffic,climate,pavement structure and material properties,and applying the principles of engineering mechanics to predict critical pavement responses.It requires significantly more input from the designer.Some of the required data are either not tracked previously or are stored in locations not familiar to designers,and many data sets need to be preprocessed for use in the MEPDG.As a result,tremendous research work has been conducted and still more challenges need to be tackled both in federal and state levels for the full implementation of MEPDG.This paper,for the first time,provides a comprehensive bird's eye view for the MEPDG procedure,including the evolvement of the design methodology,an overview of the design philosophy and its components,the research conducted during the development,improvement,and implementation phases,and the challenges remained and future developments directions.It is anticipated that the efforts in this paper aid in enhancing the mechanistic-empirical based pavement design for future continuous improvement to keep up with changes in trucking,materials,construction,design concepts,computers,and so on. | Qiang LI Danny X. XIAO Kelvin C. P. WANG Kevin D. HALL Yanjun QIU | 2011 | Journal of Modern Transportation2011，19，2： | 4 |
| 7 | Evaluating urban expansion and land use change in Shijiazhuang, China, by using GIS and remote sensing显示文摘 | Jieying Xiao Yanjun Shen Jingfeng Ge Ryutaro Tateishi Changyuan Tang Yanqing Liang Zhiying Huang | 2005 | Landscape and Urban Planning2005，，1： | 3 |
| 8 | Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein显示文摘Doppel (Dpl ) 由于结构、生物化学的类似是象蛋白质一样的 prion (PrP ) ;然而, Dpl 和 PrP 的自然功能仍然保持不清楚。在这研究,编码 Dpl 蛋白质的一个 531-bp 人 PRND 基因序列从人的外部血白细胞被放大。全身、各种各样的截断的人的 Dpl 和 PrP 蛋白质从 Escherichia 被表示并且净化 coli。全身的 Dpl 的补充导致了显著 cytotoxicity,和负责的区域到人的 neuroblastoma 房间 SH-SY5Y 上因为它的 cytotoxicity 在 Dpl 的中间的片断被印射[氨基酸(aa ) 81122 ] 。有趣地,导致 Dpl 的 cytotoxicity 被全身的野类型的 PrP 的存在反对。PrP 异种的碎片上的分析证明 N 终端碎裂(aa 2390 ) PrP 为保护的活动负责。有 Dpl 在 SH-SY5Y 房间上导致了象 Dpl 一样 cytotoxicity 的类似的第二等的结构的截断的 PrP (PrP32121 ) 。而且,铜离子的绑定能在导致 Dpl 的 cytotoxicity 上提高 PrP 的反对效果。Apoptosis 试金表明 Dpl 导致的 cytotoxicity 通过 apoptotic 机制发生了。这些结果建议 Dpl 的功能对 PrP 而非 synergistic 对抗。 | Ping Li Chenfang Dong Yanjun Lei Bing Shan Xinli Xiao Huiying Jiang Xin Wang Chen Gao Qi Shi Kun Xu Chan Tian Jun Han Xiaoping Dong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 3 |
| 9 | Coating performance on glutaraldehyde-modified wood显示文摘Scots pine(Pinus sylvestris L.) panels were modified with glutaraldehyde(GA) to various weight percent gains and subsequently coated with several commercial coatings. The drying rate and adhesion of the coatings on the modified wood were measured; the coated/modified woods were exposed outdoors to analyze how the wood modifications influence the coating deterioration. The results showed that GA modification caused an increase in the drying rate of the waterborne coatings, but had no influence on drying of tested solvent-borne coatings. GAmodification did not change the dry adhesion but reduced the wood strength in a pull-off test. Wet adhesion of waterborne coatings was improved, while that of the solvent-borne coatings tended to be somewhat reduced. During 22 months of outdoor weathering, the coated/modified samples exhibited lower moisture content than the coated/unmodified samples, but GA modification didn't contribute a substantially synergistic effect with surface coatings on resistance to weathering. | Zefang Xiao Haiou Chen Carsten Mai Holger Militz Yanjun Xie | 2019 | Journal of Forestry Research2019，30，1： | 2 |
| 10 | Incidence, risk factors for amputation among patients with diabetic foot ulcer in a Chinese tertiary hospital显示文摘 | Xiang Li Ting Xiao Yuzhen Wang Hongbin Gu Zhiguo Liu Yufeng Jiang Yanjun Liu Zuqian Lu Xiaopin Yang Yin Lan Zhangrong Xu | 2011 | Diabetes Research and Clinical Practice2011，，1： | 2 |
| 11 | Optimization of technical measures for improving high-temperature performance of asphalt-rubber mixture显示文摘Asphalt-rubber pavements often become damaged in high-temperature regions and appear rutted or wavy,and experience slippage.To improve the high-temperature performance of the asphalt-rubber mixture,technical measurements,such as,the optimal adjustment of gradation,technique of composite modification,and control of compaction were investigated.An optimal adjustment of aggregate gradation based on stone matrix asphalt improves the high-temperature stability of the asphaltrubber mixture significantly.Through composite modification,the effect of asphalt-rubber modification was enhanced,and the dynamic stability and relative deformation indices of the asphalt-rubber mixture were improved significantly.Furthermore,compaction parameters had a significant influence on the high-temperature stability of the asphalt-rubber mixture.The rolling times for compacting the asphalt-rubber mixture should be controlled to within 18-20 round-trips at a molding temperature at 180°C;if the rolling time is a 12 round-trip,the compaction temperature of the asphalt-rubber mixture should be controlled between 180 and 190°C. | Chuan Xiao Tianqing Ling Yanjun Qiu | 2013 | Journal of Modern Transportation2013，21，4： | 2 |
| 12 | Deciphering the contributions of spectral and structural data to wheat yield estimation from proximal sensing显示文摘Accurate, efficient, and timely yield estimation is critical for crop variety breeding and management optimization. However, the contributions of proximal sensing data characteristics(spectral, temporal, and spatial) to yield estimation have not been systematically evaluated. We collected long-term, hypertemporal, and large-volume light detection and ranging(Li DAR) and multispectral data to(i) identify the best machine learning method and prediction stage for wheat yield estimation,(ii) characterize the contribution of multisource data fusion and the dynamic importance of structural and spectral traits to yield estimation, and(iii) elucidate the contribution of time-series data fusion and 3 D spatial information to yield estimation. Wheat yield could be accurately(R^(2)= 0.891) and timely(approximately-two months before harvest) estimated from fused Li DAR and multispectral data. The artificial neural network model and the flowering stage were always the best method and prediction stage, respectively. Spectral traits(such as CIgreen) dominated yield estimation, especially in the early stage, whereas the contribution of structural traits(such as height) was more stable in the late stage. Fusing spectral and structural traits increased estimation accuracy at all growth stages. Better yield estimation was realized from traits derived from complete 3 D points than from canopy surface points and from integrated multi-stage(especially from jointing to heading and flowering stages) data than from single-stage data. We suggest that this study offers a novel perspective on deciphering the contributions of spectral, structural, and timeseries information to wheat yield estimation and can guide accurate, efficient, and timely estimation of wheat yield. | Qing Li Shichao Jin Jingrong Zang Xiao Wang Zhuangzhuang Sun Ziyu Li Shan Xu Qin Ma Yanjun Su Qinghua Guo Dong Jiang | 2022 | The Crop Journal2022，10，5： | 2 |
| 13 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 14 | Multi-inno- vation stochastic gradient algorithm for multiple-input single-output systems using the auxiliary model显示文摘 | Liu Yanjun Xiao Yongsong Zhao Xueliang | 2009 | Applied Mathematics and Computation2009，215，4： | 1 |
| 15 | Silane coupling agents used for natural fiber/polymer composites: A review 显示文摘 | XIE Yanjun HILL C A S XIAO Zefang | 2010 | Composites Part A2010，41，： | 1 |
| 16 | Silane couplingagents used for natural fiber/polymer composites : A review显示文摘 | XIE Yanjun HILLB CAS XIAO Zefang | 2010 | Composites: Part A2010，41，： | 1 |
| 17 | Servo motor control system based on free communication port 显示文摘 | Xiao Yanjun Guan Yuming | 2011 | IEEE2011，49，： | 1 |
| 18 | Evaluating urban expansion andland use change in Shijiazhuang, China, by using GIS and remote sensing显示文摘 | Xiao Jieying Shen Yanjun Jingfeng G | 2006 | Landscape and Urban Planning2006，75，1： | 1 |
| 19 | Evaluating urban expansion and land use change in Shijiazhuang,China,by using GIS and remote sensing 显示文摘 | Xiao Jieying Shen Yanjun Ge Jingfeng | 2006 | Landscape and Urban Planning2006，75，： | 1 |
| 20 | Two new reinforcement techniques applicable in high steep slopes along the Chengdu-Lhasa Highway, Southwest China显示文摘Anti-slide pile and anchoring hole are two types of reinforcement techniques popularly used in slope reinforcement. However, some defects of these two techniques are found in slope engineering practices. Utilizing higher tensile strength of pre-stressed structures, the authors devise two new types of slope reinforcement techniques, i.e. pre-stressed anchoring beam and pre-stressed anti-slide pile, in an attempt to overcome those defects of the existing techniques. These two new techniques are characterized by gathering multiple functions, e.g. engineering investigation, reinforcement, drainage, monitoring and strength supplement, so as to achieve high reinforcement efficiency, convenient checking, and higher ratio of function to cost. It is hoped that, if applying these two new techniques in remedies of landslide hazards along the Chengdu-Lhasa Highway, better reinforcement effects will be obtained. | YANG ZhifaZHU Jiewang ZHANG Luqing, CUI Peng, LI Xiao & SHANG Yanjun Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Resources, Chengdu 610041, China | 2003 | Science China(Technological Sciences)2003，46，z1： | 1 |
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