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| 1 | Cancer metastases: challenges and opportunities显示文摘Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Although cancer survival rate has been signi fi cantly improved over the years, the improvement is primarily due to early diagnosis and cancer growth inhibition. Limited progress has been made in the treatment of cancer metastasis due to various factors. Current treatments for cancer metastasis are mainly chemotherapy and radiotherapy, though the new generation anti-cancer drugs(predominantly neutralizing antibodies for growth factors and small molecule kinase inhibitors) do have the effects on cancer metastasis in addition to their effects on cancer growth. Cancer metastasis begins with detachment of metastatic cells from the primary tumor, travel of the cells to different sites through blood/lymphatic vessels, settlement and growth of the cells at a distal site. During the process, metastatic cells go through detachment, migration, invasion and adhesion. These four essential, metastatic steps are inter-related and affected by multi-biochemical events and parameters. Additionally, it is known that tumor microenvironment(such as extracellular matrix structure,growth factors, chemokines, matrix metalloproteinases) plays a signi fi cant role in cancer metastasis. The biochemical events and parameters involved in the metastatic process and tumor microenvironment have been targeted or can be potential targets for metastasis prevention and inhibition. This review provides an overview of these metastasis essential steps, related biochemical factors, and targets for intervention. | Xiangming Guan | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 43 |
| 2 | Gas - sensing properties of SnO2 nanobehs synthesized by thermal evaporation of Sn foil 显示文摘 | HAN Xiangming ZHANG Bing GUAN Shaokang | 2008 | J Alloy Compd2008，461，12： | 1 |
| 3 | The effects of incident light wavelength difference on the collective stimulated Brillouin scattering in plasmas显示文摘The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility.Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering(SBS),collective behaviors are excited to enhance the octad SBS.In particular,when two-color/cone lasers with wavelength separation 0.3 nm are used,the backward SBS reflectivities show novel behavior in which beams of longer wavelength achieve higher SBS gain.This property of SBS can be attributed to the rotation of the wave vectors of common ion acoustic waves due to the competition of detunings between geometrical angle and wavelength separation.This mechanism is confirmed using massively parallel supercomputer simulations with the three-dimensional laser–plasma interaction code LAP3D. | Qiang Wang Zhichao Li Zhanjun Liu Tao Gong Wenshuai Zhang Tao Xu Bin Li Ping Li Xin Li Chunyang Zheng Lihua Cao Xincheng Liu Kaiqiang Pan Hang Zhao Yonggang Liu Bo Deng Lifei Hou Yingjie Li Xiangming Liu Yulong Li Xiaoshi Peng Zanyang Guan Qiangqiang Wang Xingsen Che Sanwei Li Qiang Yin Wei Zhang Liqiong Xia Peng Wang Xiaohua Jiang Liang Guo Qi Li Minqing He Liang Hao Hongbo Cai Wudi Zheng Shiyang Zou Dong Yang Feng Wang Jiamin Yang Baohan Zhang Yongkun Ding Xiantu He | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
| 4 | Best-effort service QoE assessment using visual information based Weber-Fechner law显示文摘Quality of experience(QoE) has been one of the most important factors for service providers and operators to develop and deploy services. Previous works have shown that Weber-Fechner law(WFL) can be used to promote the accuracy of best-effort(BE) services' QoE assessment. In this paper, based on WFL, we take a deep insight into the visual information of BE services and its role in WFL, especially in web browsing services, and propose an enhanced QoE assessment model for BE services by taking the visual information into account. Both images and texts visual information are extracted and combined to get the visual information for web pages. Finally, a subjective experiment is performed to validate performance of proposed QoE assessment model, which shows that it performs better than traditional WFL based model. | Guan Wanqing Wang Luhan Lu Zhaoming Wen Xiangming Chen Xin | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，2： | 0 |
| 5 | Editorial of Virtual Special Issue on Progress in Medicinal Chemistry显示文摘Editorial Drug target identification is a key step in the development of effective therapeutic agents.In this issue,we present the current status of some validated and potential targets in drug discovery for developing therapeutic agents for the treatment of cancer,inflammation,cardiovascular diseases,neurodegenerative diseases,HIV,and influenza A virus.I am indebted to my colleagues for their cooperation and efforts to find time from their busy schedule | Xiangming Guan | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 0 |
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