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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Methodologic research on TIMP-1,TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance显示文摘AIM: To set up a new method to detect tissue inhibitors ofmetalloproteinase1 and -2(TIMP-1 and TIMP-2) in sero ofpatients with hepatic cirrhosis, and to investigate theexpression and location of TIMP-1 and TIMP-2 in liver tissueof patients with hepatic cirrhosis, and the correlationbetween TIMPs in liver and those in sera so as to discusswhether TIMPs can be used ss a diagnosis index of hepaticfibrosisMETHODS: The monoclonal antibodies (McAbs) of TIMP-1and TIMP-2 were used to sensitize erythrocytes, and solid-phase absorption to sensitized erythrocytes (SPASE) wasused to detect TIMP-1 and TIMP-2 in the sera of patients withhepatic cirrhosis. Meanwhile, with the method of in situhybridization and immunohistochemistry, we studied themRNA expression and antigen location of TIMP-1 and TIMP-2in the livers of 40 hepatic cirrhosis patients with pathologicdiagnosis.RESULTS: With SPASE, they were 16.4 % higher in theacute hepatitis group, 33.3 % higher in the chronic hepatitisgroup, and the positive rates were 73.6 % and 61. 2 %respectively in sero of hepatic cirrhosis patients, which wereremarkably higher than those in chronic hepatitis and acutehepatitis group ( P < 0. 001 ). In 40 samples of hepaticcirrhosis tissues, all of them showed positive expression ofTIMP-1 and TIMP-2 mRNA detected withimmunohistochemistry or in situ hybridization (positive ratewas 100 % ). Expression of TIMPs in different degrees couldbe found in liver tissue with cirrhosis. TIMPs were located incytoplasm of liver cells of patients with hepatic cirrhosis.There was a significant correlation between serum TIMPslevel and liver TIMPs level.CONCLUSION: SPASE is a useful method to detect the TIMP-1 and TIMP-2 in sera of patients with hepatic cirrhosis, andTIMP-1 and TIMP-2 can be considered as a useful diagnosticindex of hepatic fibrosis, especially TIMP-1. | Oing-He Nie Yong-Oian Cheng Yu-Mei Xie Yong-Xing Zhou Bai-Xian Guang Yi-Zhan Cao,The Centre of Diagnosis and Treatment for Infectious Disease of Chinese PLA,Tangdu Hospital,Fourth Military Medical University,Xi’an 710038,Shanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 51 |
| 3 | Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study显示文摘 | WEN Ying JIANG Li XU Yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI Yu- hang WU Da-wei WANG Yu-shan SUN Ren-hua HU Zhen-jie CAO Xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA Xiao-chun YU Xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin | 2013 | Chinese Medical Journal2013，，23： | 40 |
| 4 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 5 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 6 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 7 | Quantum secure direct communication with cluster states显示文摘A quantum secure direct communication protocol with cluster states is proposed.Compared with the deterministic secure quantum communication protocol with the cluster state proposed by Yuan and Song(Int.J.Quant.Inform.,2009,7:689),this protocol can achieve higher intrinsic efficiency by using two-step transmission.The implementation of this protocol is also discussed. | CAO WeiFeng 1,YANG YuGuang 3,4,5* & WEN QiaoYan 2 1 College of Electric and Information Engineering,Zhengzhou University of Light Industry,Zhengzhou 450002,China 2 State Key Laboratory of Networking and Switching Technology,Beijing University of Posts and Telecommunications,Beijing 100876,China 3 College of Computer Science and Technology,Beijing University of Technology,Beijing 100124,China 4 State Key Laboratory of Integrated Services Network,Xidian University,Xi’an 710071,China 5 State key Laboratory of Information Security Gradute University of Chinese Academy of Sciences,Beijing 100049,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，7： | 20 |
| 8 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 9 | The δ^(18)O variation of a stalagmite from Qixing Cave,Guizhou Province and indi-cated climate change during the Holocene显示文摘A stalagmite from Qixing Cave, Guizhou Province was dated with the TIMS U-series method and its oxygen isotope composition was analyzed. On the basis of the ages and the variations of the δ18O of the stalagmite, the climate change of the last 7.7 ka has been reconstructed in this area: 7.7-5.8 ka, summer monsoon maximum period; 5.8-3.8 ka summer monsoon weakening period; 3.8-0.15 ka, weakened summer monsoon and high amplitude climate fluctuations period. We put forward that the increasing trend of δ18O of the stalagmite reflected not only the weakening of the summer monsoon, which was caused by the decreasing of solar radiation in the Northern Hemisphere, but also the possibly decreasing contribution of the southwest monsoon to the rainfall of this area. These results are consistent with the output of the numerical climate-model modeling. The high amplitude fluctuation of the δ18O may imply the quick shift of the contributions of different moisture sources to the precipitation in this area. | CAI Yanjun, ZHANG Meiliang, PENG Zicheng, LIN Yushi, AN Zhisheng, ZHANG Zhaofeng & CAO YunningState Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710054, China Karst Dynamics Laboratory, Ministry of Land and Resources, Guilin 541003, China Department of Earth and Space Science, University of Science & Technology of China, Hefei 230023, China | 2001 | Chinese Science Bulletin2001，46，22： | 18 |
| 10 | Characteristics and origin of abnormally high porosity zones in buried Paleogene clastic reservoirs in the Shengtuo area, Dongying Sag, East China显示文摘There are three abnormally high porosity zones developed in buried Paleogene nearshore subaqueous fan and sublacustrine fan clastic reservoirs at 2,800-3,200 m, 3,250-3,700 m and 3,900-4,400 m, respectively, within the Shengtuo area of the Dongying Sag. Here the porosity of reservoirs buried deeper than 4,000 m can still be greater than 20%. Investigation of these three abnormally high porosity(AHP) zones in the 3rd to 4th member of the Paleogene Shahejie Formation in the Shengtuo area was carried out with utilization of core observation, thin section identification, SEM observation, image analysis, core physical property testing and other technical methods. The results show that, the AHP zones in 2,800-3,200 m and 3,250-3,700 m are visible pores primary AHP zones dominated by significant primary intergranular pores(more than 50% of the total porosity), while secondary pores and micropores in authigenic clays may develop in some reservoirs. AHP reservoirs in the AHP zone of 3,900-4,400 m are dominated by micropores in matrix, visible pores are mainly grain dissolution pores but with low absolute content(< 1%), so this zone belongs to the micropores primary AHP zone. The genesis of the three AHP zones was studied to distinguish between porosity enhancement and porosity preservation. Our research shows that, in deeply buried clastic reservoirs in the Shengtuo area, mineral dissolution occurred in a relatively closed diagenetic system with high temperature and high salinity. Reservoir rocks underwent extensive feldspar dissolution, while detrital carbonate grains and carbonate cements show no evidence of extensive dissolution. Although significant feldspar dissolution pores developed, feldspar dissolution enhanced porosity only a little due to the precipitation of almost isovolumetric dissolution products in the nearby primary intergranular pores in forms of authigenic clays and quartz cements. Net enhanced porosity originating from feldspar dissolution is generally less than 0.25%. Thus, the subsurface dissolution has little impact on the mid-deep buried high porosity reservoirs. Reservoirs in braided channels of middle fans in sublacustrine fans and reservoirs in the middle-front of fan bodies of nearshore subaqueous fans provide the basis for the development of AHP zones. The shallow development of fluid overpressure and early hydrocarbon emplacement have effectively retarded compaction and carbonate cementation, so that the high porosity in the superficial layers is preserved in the mid-deep layers. These are the main controlling factors in the development of AHP zones. | Cao Yingchang Yuan Guanghui Li Xiaoyan Wang Yanzhong Xi Kelai Wang Xiaoming Jia Zhenzhen Yang Tian | 2014 | Petroleum Science2014，11，3： | 18 |
| 11 | Prevalence of isolated systolic hypertension and analysis on its relative factors in 1002 cases over 80 years old in retirement centers for army officers显示文摘现在,尽管有高血压,了解率和控制的高流行,这疾病的率仍然是很低的。另外,在旧人口的高血压的流行很高,并且大多数盒子被孤立收缩高血压(ISH ) 。Weinvestigated 人在 28 干部退休从 80 ~ 99 年在年龄在北京集中学习目标机关损害的流行和发生并且分析 ISH 的相对因素。 | LI Yan-fang CAO Jian FAN Li BU Cong-ya LI Xi WANG Long-hua CHENG Xiu-qin NIE Xiao-min WU Xiao-ying | 2006 | Chinese Medical Journal2006，，17： | 17 |
| 12 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 13 | Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma显示文摘BACKGROUND:Gallbladder adenoma is a pre-cancerous neoplasm and needs surgical resection.It is difficult to differentiate adenoma from other gallbladder polyps using imaging examinations.The study aimed to illustrate characteristics of contrast-enhanced ultrasound(CEUS)and its diagnostic value in gallbladder adenoma. | Hai-Xia Yuan Jia-Ying Cao Wen-Tao Kong Han-Sheng Xia Xi Wang Wen-Ping Wang | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 17 |
| 14 | Involvement of carbon monoxide produced by heme oxygenase in ABA-induced stomatal closure in Vicia faba and its proposed signal transduction pathway显示文摘Carbon monoxide (CO) has recently proven to be an important bioactive or signaling molecule in mammalian cells. Its effects are mainly mediated by nitric oxide (NO) and cyclic GMP (cGMP). In Vicia faba leaves, CO production and heme oxygenase (HO) activity, an important CO synthetic enzyme, are first reported to increase in response to ABA treatment, which could result in stomatal closure. Inter- estingly, ABA-induced stomatal closure in V. faba guard cells is partially blocked when the synthetic CO inhibitor ZnPP, or the CO/NO scavenger Hb is added. Furthermore, we show that, exogenously applied CO donor, hematin, and CO aqueous solution not only result in the enhancement of CO release, but also time-dependently induce stomatal closure, and the latter is mimicked by the application of an NO donor SNP. The above-mentioned stomatal closure effects are differentially reversed by the addition of tungstate, a potent inhibitor of NO synthetic enzyme nitrate reductase (NR), the specific NO scavenger cPTIO, ZnPP, or Hb. During treatment for 4 h, SNP, 0.01% CO aqueous solution or hematin significantly triggers NO synthesis, whereas cPTIO, or tungstate approximately fully inhibits NO fluorescence. Ad- ditionally, application of the GC inhibitor ODQ blocks CO-induced stomatal closure. This inhibition could be reversed when 8-Br-cGMP is added. Thus, the above results suggest that CO produced by HO is involved in ABA-induced stomatal closure, and NO and cGMP may function as downstream interme- diates in the CO signaling responsible for stomatal closure. | CAO ZeYu HUANG BenKai WANG QingYa XUAN Wei LING TengFang ZHANG Bo CHEN Xi NIE Li SHEN WenBiaot | 2007 | Chinese Science Bulletin2007，52，17： | 16 |
| 15 | Air route network optimization in fragmented airspace based on cellular automata显示文摘Air route network optimization,one of the essential parts of the airspace planning,is an effective way to optimize airspace resources,increase airspace capacity,and alleviate air traffic congestion.However,little has been done on the optimization of air route network in the fragmented airspace caused by prohibited,restricted,and dangerous areas(PRDs).In this paper,an air route network optimization model is developed with the total operational cost as the objective function while airspace restriction,air route network capacity,and non-straight-line factors(NSLF) are taken as major constraints.A square grid cellular space,Moore neighbors,a fixed boundary,together with a set of rules for solving the route network optimization model are designed based on cellular automata.The empirical traffic of airports with the largest traffic volume in each of the 9 flight information regions in China's Mainland is collected as the origin-destination(OD) airport pair demands.Based on traffic patterns,the model generates 35 air routes which successfully avoids 144 PRDs.Compared with the current air route network structure,the number of nodes decreases by 41.67%,while the total length of flight segments and air routes drop by 32.03% and 5.82% respectively.The NSLF decreases by 5.82% with changes in the total length of the air route network.More importantly,the total operational cost of the whole network decreases by 6.22%.The computational results show the potential benefits of the model and the advantage of the algorithm.Optimization of air route network can significantly reduce operational cost while ensuring operation safety. | Shijin WANG Xi CAO Haiyun LI Qingyun LI Xu HANG Yanjun WANG | 2017 | Chinese Journal of Aeronautics2017，30，3： | 16 |
| 16 | MHD Flow Control of Oblique Shock Waves Around Ramps in Low-temperature Supersonic Flows显示文摘This article is devoted to experimental study on the control of the oblique shock wave around the ramp in a low-temperature supersonic flow by means of the magnetohydrodynamic(MHD) flow control technique.The purpose of the experiments is to take advantage of MHD interaction to weaken the oblique shock wave strength by changing the boundary flow characteristics around the ramp.Plasma columns are generated by pulsed direct current(DC) discharge,the magnetic fields are generated by Nd-Fe-B rare-earth permanent magnets and the oblique shock waves in supersonic flow are generated by the ramp.The Lorentz body force effect of MHD interaction on the plasma-induced airflow velocity is verified through particle image velocimetry(PIV) measurements.The experimental results from the supersonic wind tunnel indicate that the MHD flow control can drastically change the flow characteristics of the airflow around the ramp and decrease the ratio of the Pitot pressure after shock wave to that before it by up to 19.66%,which leads to the decline in oblique shock wave strength.The oblique shock waves in front of the ramp move upstream by the action of the Lorentz body force.The discharge characteristics are analyzed and the MHD interaction time and consumed energy are determined with the help of the pulsed DC discharge images.The interaction parameter corresponding to the boundary layer velocity can reach 1.3 from the momentum conservation equation.The velocity of the plasma column in the magnetic field is much faster than that in the absence of magnetic field force.The plasma can strike the neutral gas molecules to transfer momentum and accelerate the flow around the ramp. | Su Changbing,Li Yinghong,Cheng Bangqin,Wang Jian,Cao Jun,Li Yiwen Engineering College,Air Force Engineering University,Xi’an 710038,China | 2010 | Chinese Journal of Aeronautics2010，23，1： | 15 |
| 17 | Serum hepatitis B virus RNA is a predictor of HBeAg seroconversion and virological response with entecavir treatment in chronic hepatitis B patients显示文摘BACKGROUND Characteristics of alterations of serum hepatitis B virus(HBV) RNA in different chronic hepatitis B(CHB) patients still cannot be fully explained. Whether HBV RNA can predict HBeAg seroconversion is still controversial.AIM To investigate whether HBV RNA can predict virological response or HBeAg seroconversion during entecavir(ETV) treatment when HBV DNA is undetectable.METHODS The present study evaluated 61 individuals who were diagnosed and treated with long-term ETV monotherapy at the Department of Infectious Diseases of Peking University First Hospital(China) from September 2006 to December 2007.Finally, 30 treatment-naive individuals were included. Serum HBV RNA were extracted from 140 μL serum samples at two time points. Then they were reverse transcribed to cDNA with the HBV-specific primer. The product was quantified by real-time quantitative PCR(RT-PCR) using TAMARA probes. Statistical analyses were performed with IBM SPSS 20.0.RESULTS Level of serum HBV RNA at baseline was 4.15 ± 0.90 log10 copies/mL. HBV RNA levels showed no significant difference between the virological response(VR)and partial VR(PVR) groups at baseline(P = 0.940). Serum HBV RNA significantly decreased among patients who achieved a VR during ETV therapy(P < 0.001). The levels of HBV RNA in both HBeAg-positive patients with seroconversion group and those with no seroconversion increased after 24 wk of treatment. Overall, HBV RNA significantly but mildly correlated to HBsAg(r =0.265, P = 0.041), and HBV RNA was not correlated to HBV DNA(r = 0.242, P =0.062). Furthermore, serum HBV RNA was an independent indicator for predicting HBeAg seroconversion and virological response. HBeAg seroconversion was more likely in CHB patients with HBV RNA levels below4.12 log10 copies/mL before treatment.CONLUSION The level of serum HBV RNA could predict HBeAg seroconversion and PVR during treatment. In the PVR group, the level of serum HBV RNA tends to be increasing. | Hao Luo Xia-Xia Zhang Li-Hua Cao Ning Tan Qian Kang Hong-Li Xi Min Yu Xiao-Yuan Xu | 2019 | World Journal of Gastroenterology2019，25，6： | 15 |
| 18 | Decision-Making in Driver-Automation Shared Control:A Review and Perspectives显示文摘Shared control schemes allow a human driver to work with an automated driving agent in driver-vehicle systems while retaining the driver’s abilities to control.The human driver,as an essential agent in the driver-vehicle shared control systems,should be precisely modeled regarding their cognitive processes,control strategies,and decision-making processes.The interactive strategy design between drivers and automated driving agents brings an excellent challenge for human-centric driver assistance systems due to the inherent characteristics of humans.Many open-ended questions arise,such as what proper role of human drivers should act in a shared control scheme?How to make an intelligent decision capable of balancing the benefits of agents in shared control systems?Due to the advent of these attentions and questions,it is desirable to present a survey on the decision making between human drivers and highly automated vehicles,to understand their architectures,human driver modeling,and interaction strategies under the driver-vehicle shared schemes.Finally,we give a further discussion on the key future challenges and opportunities.They are likely to shape new potential research directions. | Wenshuo Wang Xiaoxiang Na Dongpu Cao Jianwei Gong Junqiang Xi Yang Xing Fei-Yue Wang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，5： | 14 |
| 19 | Geochronological evidence of Indosinian(high-pressure) metamorphic event and its tectonic significance in Taxkorgan area of the Western Kunlun Mountains,NW China显示文摘The CL images,LA-ICP-MS in situ trace elements analysis,and U-Pb dating for zircons indicate that the metamorphic ages of the sillimanite-garnet-biotite gneiss and the garnet-amphibole gneiss from eastern Taxkorgan of the Western Kunlun Mountains are 220±2 and 220±3 Ma respectively,and their protolith ages are younger than 253±2 and 480±8 Ma respectively.Two samples were collected at the same outcrops with HP mafic granulite and HP pelitic granulite.Mineral assemblage of the sillimanite-garnet-biotite gneiss(Grt+Sill+Per+Q) is consistent with that of HP pelitic granulite at early high amphibolite-granulite facies stage.Mineral assemblage of the garnet-amphibole gneiss(Grt+Amp+Pl+Q) is consistent with retro-metamorphic assemblage of HP mafic granulite at amphibolite facies stage.The dating results suggest that these HP granulites underwent peak metamorphism at 220±2 to 253±2 Ma.Thus,the Kangxiwar tectonic zone was probably formed by subduction and collision of the Paleo-Tethys Ocean during Indosinian.Protolith ages of the two samples,together with previously published U-Pb zircon dating age,suggest that the sillimanite-garnet schist-quartzite unit is a late Paleozoic unit,not a part of the Paleoproterozoic Bulunkuole Group. | YANG WenQiang1,LIU Liang1,CAO YuTing1,WANG Chao1,2,HE ShiPing2,LI RongShe2 & ZHU XiaoHui1 1 State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi’an 710069,China 2 Xi’an Institute of Geology and Mineral Resource,Xi’an 710054,China | 2010 | Science China Earth Sciences2010，53，10： | 13 |
| 20 | Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus显示文摘BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-F4,and surpassing other serum panels.However,AUROC (0.747) in Model C used for the diagnosis of F4 from F0-F3 was lower than AUROC (0.795) in FIB-4.In combination with ALT and PLT,the multiparameter models showed better diagnostic power (AUROC=0.912,0.829,0.885,respectively) when compared with other models.In the validation group,the AUROCs of the three combined models (0.929,0.858,and 0.867,respectively) were still satisfactory.We also applied the combined models to distinguish adjacent fibrosis stages of 432patients (F0-F1/F2/F3/F4),and the AUROCs were 0.917,0.720 and 0.785.CONCLUSION Multiparameter models based on serum N-glycans are effective supplementary markers to distinguish between adjacent fibrosis stages of patients caused by HBV,especially in combination with ALT and PLT. | Xi Cao Qing-Hua Shang Xiao-Ling Chi Wei Zhang Huan-Ming Xiao Mi-Mi Sun Gang Chen Yong An Chun-Lei Lv Lin Wang Yue-Min Nan Cui-Ying Chen Zong-Nan Tan Xue-En Liu Hui Zhuang | 2020 | World Journal of Gastroenterology2020，26，10： | 12 |
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