|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Formu- lation of poorly water-soluble compound loaded solid lipid nanopartieles in a mierochannel system fabricated by mechanical microeutting method: puerarin as a model drug 显示文摘 | XU Linhong TAN Xu YUN Junxian | 2012 | Industrial and Engineering Chemistry Research2012，51，11： | 1 |
| 3 | Synthesis of BFPT perovskite powders by high-energy ball milling 显示文摘 | Lin Zhang Zhuo Xu Linhong Cao Xi Yao | 2007 | Materials Letters2007，67，2： | 1 |
| 4 | Formulation of Poorly Water-Soluble Compound Loaded Solid Lipid Nanoparticles in a Microchannel System Fabricated by Mechanical Microcutting Method: Puerarin as a Model Drug显示文摘 | Linhong X Xu T Junxian Y Shaochuan S | 2012 | Industrial & Engineering Chemistry Research2012，51，11： | 1 |
| 5 | Computer Aided Design Technology for Convex Faceted Gem Cuts Based on the Half-Edge Data Structure显示文摘Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration. | Linhong Xu Xiangnan Li Jianhua Rao Yuan Han Zhipeng Li Jichun Li | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 1 |
| 6 | Soluble ADAM33 determines mechanical behaviors of airway smooth muscle cells显示文摘Introduction A disintegrin and metalloproteinase 33(ADAM33)has been identified as a susceptibility gene for asthma[1],In particular,ADAM33 mRNA is highly expressed in airway smooth muscle cells(ASMCs)and the level of soluble ADAM33(sADAM33)is known to inversely correlate with lung function such as bronchial hyperresponsiveness(BHR)[2]that is ultimately determined by the mechanical behaviors of ASMCs.However,few have studied how sADAM33would affect ASMC mechanics.Here,we manipulated the expression of SADAM33 in | Yiyuan Duan Jiaoyue Long Feng Lin Jun Chen Rong Xu Xuemei Jiang Linhong Deng | 2013 | 医用生物力学2013，28，S1： | 1 |
| 7 | Key-Recovery Attacks on LED-Like Block Ciphers显示文摘Asymmetric cryptographic schemes, represe nted by RSA, have bee n show n to be in secure un der quantum computing conditions. Correspondingly, there is a need to study whether the symmetric cryptosystem can still guarantee high security with the advent of quantum computers. In this paper, based on the basic principles of classical slide attacks and Simon's algorithm, we take LED-like lightweight block ciphers as research objects to present a security analysis under both classical and quantum attacks, fully considering the influence on the security of the ciphers of adding the round constants. By analyzing the information leakage of round constants, we can introduce the differential of the round constants to propose a classical slide attack on full-round LED-64 with a probability of 1. The analysis result shows that LED-64 is unable to resist this kind of classical slide attack, but that attack method is not applicable to LED-128. As for quantum attacks, by improving on existing quantum attack methods we dem on strate a qua ntum single-key slide attack on LED-64 and a quantum related-key attack on LED- 128, and indicators of the two attack algorithms are analyzed in detail. The attack results show that adding round consta nts does not completely improve the security of the ciphers, and quantum attacks can provide an exp on ential speed-up over the same attacks in the classical model. It further illustrates that the block cipher that is proved to be safe under classical settings is not necessarily secure under quantum conditions. | Linhong Xu Jiansheng Guo Jingyi Cui Mingming Li | 2019 | Tsinghua Science and Technology2019，24，5： | 1 |
| 8 | Finding maximal cliques in massive networks显示文摘 | James Cheng Yiping Ke Ada Wai-Chee Fu Jeffrey Xu Yu Linhong Zhu | 2011 | ACM Transactions on Database Systems (TODS)2011，，4： | 1 |
| 9 | The Application of Virtual Reality Technology in Constructing Virtual Machining Workshop显示文摘 | Linhong Xu Zhengfeng Jiang Hong Lu | 2008 | Lecture Notes in Computer Science2008，，： | 1 |
| 10 | Prevalence of Reproductive Tract Infections and Association with Human Papillomavirus Infection Among Reproductive-Age Women—Six Tertiary Hospitals,China,June 2021-December 2022显示文摘Summary What is already known about this topic?Previous studies have indicated a possible association between reproductive tract infections(RTIs)and highrisk human papillomavirus(HPV)infection,but the evidence is still inconclusive.What is added by this report?This multicenter study found significantly higher positive rates of HPV,including general HPV,highrisk HPV. | Di Gao Jiayue Li Gengli Zhao Zhaohui Liu Hui Bi Dai Zhang Fengxia Xue Chen Liu Hongtao Ma Bei Lin Xu Wang Xiaosong Zhang Linhong Wang | 2024 | China CDC weekly2024，6，10： | 0 |
| 11 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 12 | Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling显示文摘Drug-associated reward memories are conducive to intense craving and often trigger relapse.Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is elusive.Here,we used a mass spectrometry-based lipidomic method to evaluate the impact of simvastatin on the mouse brain in a cocaine-induced reinstatement paradigm.We found that simvastatin blocked the reinstatement of cocaine-induced conditioned place preference(CPP)without affecting CPP acquisition.Specifically,only simvastatin administered during extinction prevented cocaine-primed reinstatement.Global lipidome analysis showed that the nucleus accumbens was the region with the greatest degree of change caused by simvastatin.The metabolism of fatty-acids,phospholipids,and triacylglycerol was profoundly affected.Simvastatin reversed most of the effects on phospholipids induced by cocaine.The correlation matrix showed that cocaine and simvastatin significantly reshaped the lipid metabolic pathways in specific brain regions.Furthermore,simvastatin almost reversed all changes in the fatty acyl profile and unsaturation caused by cocaine.In summary,pre-extinction treatment with simvastatin facilitates cocaine extinction and prevents cocaine relapse with brain lipidome remodeling. | Wei Xu Yuman He Jiamei Zhang Hongchun Li Xuemei Wan Menglu Li Yonghai Wang Rui Xu Haoluo Zhang Yanping Dai Haxiaoyu Liu Linhong Jiang Ying Zhao Xiaobo Cen | 2021 | Neuroscience Bulletin2021，37，12： | 0 |
| 13 | REAL-t1, an Effective Approach for t1-Noise Suppression in NMR Spectroscopy Based on Resampling Algorithm显示文摘Summaryof main observation and conclusionIn multidimensional(nD)NMR spectroscopy,t1noise usually appears as ridges along indirect dimen-sions,and affects observation of weak signals.The main source of t1noise is instrumental instability,which causes random variation of FID amplitude during data acquisitions and introduces random noise-like peaks into spectrum after Fourier transformation.A number of efforts have been devoted,in order to develop new method or to improve existing approaches for suppressing t1noise.Herein,we propose a novel t1noise suppression method based on resampling algorithm for data processing,shortenedas REAL-t1.The method was verified using simulated 2D spectra,and NOESY spectra of sucrose and protein GB1,showing that the spectral quality was improved in all cases.The performance of REAL-t1was also compared with another recently pro-posed method,which showed that these two methods provided similar performance while REAL-t1cost much shorter experimental time. | Linhong Song Jiannan Wang Xuncheng Su Xu Zhang Conggang Li Xin Zhou Daiwen Yang Bin Jiang Maili Liu | 2020 | Chinese Journal of Chemistry2020，38，1： | 0 |
| 14 | The effect of inhibitor peptide for ADAM8 in attenuating ovalbumin-induced murine asthma显示文摘Targeted peptides have been identified as showing great promise for treatment of various diseases including asthma.Asthma is considered of difficuIt-to-treat due to its unclear etiology,thus usually requiring life-long treatment.Current strategies for asthma therapy are hampered with undesirable side effects,poor targeting and failure in modulating airway hyperresponsiveness,leading to pressing need of developing more targeted and effective therapeutic sites for asthma.Recently,a disintegrin and metalloproteinase 8(ADAM8)have been shown to over- | Jun Chen Xuemei Jiang Yiyuan Duan Jiaoyue Long Feng Lin Rong Xu Xiaojuan Zhang Linhong Deng | 2013 | 医用生物力学2013，28，S1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员