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| 1 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 2 | Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model显示文摘Dear Editor,Respiratory syncytial virus(RSV)is the leading cause of serious lower respiratory tract disease in children under 5 years of age worldwide,causing an estimated 3.2 million hospitalizations and 120,000 deaths in children globally per year.Furthermore,nearly all children can be infected with RSV by 2 years of age,and individuals can be repeatedly re-infected with RSV throughout life,which poses great threats to infants,the elderly. | Ruxue Zhang Yumin Zhang Wei Zheng Weijuan Shang Yan Wu Ning Li Jun Xiong Hualiang Jiang Jingshan Shen Gengfu Xiao Yuanchao Xie Leike Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 3 | A meta-analysis of DNA repair gene XPC polymorphisms and cancer risk显示文摘 | Deqiang Zhang Chengwen Chen Xuping Fu Shaohua Gu Yumin Mao Yi Xie Yan Huang Yao Li | 2008 | Journal of Human Genetics2008，，1： | 1 |
| 4 | Fabrication and microstructure investigation of ultra-high-strength porcelain insulator显示文摘 | Yong Meng Guohong Gong Zhengping Wu Zhongju Yin Yumin Xie Shirong Liu | 2012 | Journal of the European Ceramic Society2012，，12： | 1 |
| 5 | Fabrication and microstructure investigation of ultra-high-strength porcelain insulator显示文摘 | Yong Meng Guohong Gong Zhengping Wu Zhongju Yin Yumin Xie Shirong Liu | 2012 | Journal of the European Ceramic Society2012，，12： | 1 |
| 6 | Cloning and Identification of a Novel cDNA1 Which May Be Associated with FKBP25显示文摘 | Xianfang Meng Jinzhong Chen Quansheng Yang Shu Wang Yaoqiong Chao Kang Ying Yi Xie Yumin Mao | 2002 | Biochemical Genetics (-)2002，，9： | 1 |
| 7 | Synthesis and Characterization of a Novel Aliphatic Polyester Based on Itaconic Acid显示文摘 | Yumin Wu Qingwei Xie Chuanhui Gao | 2014 | Polymer Engineering And Science2014，54，11： | 1 |
| 8 | Screening of flocculant-producing microorganisms and some characteristics of flocculants显示文摘 | Wang zhen Wang kongxing Xie yumin | 1994 | Biotechnology Techniques1994，8，11： | 1 |
| 9 | Bioflocculant-Producing Microorganisms显示文摘 | Wang Kongxing Xie Yumin | 1995 | Chinese Science Abstracts Series B1995，14，3： | 1 |
| 10 | Isolation and identification of a novel cDNA that encodes human yrdC protein显示文摘 | Jinzhong Chen Chaoneng Ji Shaohua Gu Enpeng Zhao Jianliang Dai Lu Huang Ji Qian Kang Ying Yi Xie Yumin Mao | 2003 | Journal of Human Genetics2003，，4： | 1 |
| 11 | A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir显示文摘During the ongoing pandemic,providing treatment consisting of effective,low-cost oral antiviral drugs at an early stage of SARSCoV-2 infection has been a priority for controling COVID-19.Although Paxlovid and molnupiravir have received emergency approval from the FDA,some side effect concerns have emerged,and the possible oral agents are stillimited,resulting in optimized drug development becoming an urgent requirement. | Yumin Zhang Yuan Sun Yuanchao Xie Wejuan Shang Zhen Wang Hualiang Jiang Jingshan Shen Gengfu Xiao Leike Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 1 |
| 12 | Computer security education teaching exploration显示文摘 | Xie Yumin LiuYu ji | | 0，，： | 1 |
| 13 | Transmutation Scheme of Coin Flipping Protocol and Utilization显示文摘Coin flipping by telephone protocol(CFP) is utilized in a system to exchange a binary sequence at random between two person apart far from each other. However, CFP cannot be used in a system with many users like in a group environment system. A transmutation of CFP named T-CFP is proposed in this paper. The precondition of T-CFP is the system’s user trusts the system center and center’s cheating is meaningless at the same time. The significant difference between CFP and T-CFP is that CFP supports only two users while T-CFP can support many users to exchange special information. The security and efficiency of T-CFP are discussed with a detailed example on T-CFP utilization is demonstrated in this paper. | XIE Yumin MING Yang SHI Feng MUHAMMAD Kamran | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 0 |
| 14 | Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer显示文摘Background: New therapeutic targets are needed to improve the outcomes for gastric cancer(GC) patients with advanced disease. Evasion of programmed cell death(apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the pro-survival BCL2 family proteins represents a promising therapeutic strategy for cancer treatment. Therefore, understanding the molecular mechanisms underpinning cancer cell survival could provide a molecular basis for potential therapeutic interventions. Method: Here we explored the role of BCL2L1 and the encoded anti-apoptotic BCL-XL in GC. Using Droplet Digital PCR(ddPCR) technology to investigate the DNA amplification of BCL2L1 in GC samples and GC cell lines, the sensitivity of GC cell lines to selective BCL-XL inhibitors A1155463 and A1331852, pan-inhibitor ABT-263, and VHL-based PROTAC-BCL-XL was analyzed using(CellTiter-Glo) CTG assay in vitro. Western Blot(WB) was used to detect the protein expression of BCL2 family members in GC cell lines and the manner in which PROTAC-BCL-XL kills GC cells. Coimmunoprecipitation(Co-IP) was used to investigate the mechanism of A1331852 and ABT-263 kills GC cell lines. DDPCR, WB, and real-time PCR(RTPCR) were used to investigate the correlation between DNA, RNA, protein levels, and drug activity. Results: The functional assay showed that a subset of GC cell lines relies on BCL-XL for survival. In gastric cancer cell lines, BCL-XL inhibitors A1155463 and A1331852 are more sensitive than the pan BCL2 family inhibitor ABT-263, indicating that ABT-263 is not an optimal inhibitor of BCL-XL. VHL-based PROTAC-BCL-XL DT2216 appears to be active in GC cells. DT2216 induces apoptosis of gastric cancer cells in a time-and dose-dependent manner through the proteasome pathway. Statistical analysis showed that the BCL-XL protein level predicts the response of GC cells to BCL-XL targeting therapy and BCL2L1 gene CNVs do not reliably predict BCL-XL expression.Conclusion: We identified BCL-XL as a promising therapeutic target in a subset of GC cases with high levels of BCL-XL protein expression. Functionally, we demonstrated that both selective BCL-XL inhibitors and VHL-based PROTAC BCL-XL can potently kill GC cells that are reliant on BCL-XL for survival. However, we found that BCL2L1 copy number variations(CNVs) cannot reliably predict BCL-XL expression, but the BCL-XL protein level serves as a useful biomarker for predicting the sensitivity of GC cells to BCL-XL-targeting compounds. Taken together, our study pinpointed BCL-XL as potential druggable target for specific subsets of GC. | Yumin Wei Liping Zhang Chao Wang Zefeng Li Mingjie Luo Guomin Xie Xingjiu Yang Mengyuan Li Shuyue Ren Dongbing Zhao Ran Gao Jia-Nan Gong | 2023 | Animal Models and Experimental Medicine2023，6，3： | 0 |
| 15 | ROLE OF DISEASE PROPAGATION IN MIGRATORY BIRD POPULATION显示文摘 | SHUJING GAO YUMIN DING JIANPING XIE | 2012 | International Journal of Biomathematics2012，5，3： | 0 |
| 16 | Crystal structure of thermostable catechol 2,3-dioxygenase determined by multiwavelength anomalous dispersion method显示文摘The selenomethionyl derivative of the thermo-stable catechol 2,3-dioxygenase (SeMet-TC23O) is expressed, purified and crystallized. By using multiwave length anoma-lous dispersion (MAD) phasing techniques, the crystal structure of TC23O at 0.3 nm resolutions is determined. TC23O is a homotetramer. Each monomer is composed of N-terminal and C-terminal domains (residues 1-153 and 153-319, respectively). The two domains are proximately symmetric by a non-crystallographic axis. Each domain contains two characteristic motifs which are found in almost all of extradial dioxygenases. | JIANG Tao JI Chaoneng SHENG Xiaoyu CHEN Mingqin XIE Yi GONG Weimin MAO Yumin | 2002 | Chinese Science Bulletin2002，47，4： | 0 |
| 17 | Intermediate phase assisted sequential deposition of reverse-graded quasi-2D alternating cation perovskites for MA-free perovskite solar cells显示文摘One-step deposition approaches have been widely applied and developed in the fabrication of quasi-2D perovskites.However,the regulation of quantum wells(QWs)and crystalline orientation is difficult and complicated when using this methodology.Sequential deposition is another widespread synthetic approach for preparing perovskite films and perovskite dimension engineering.In this article,δ-CsPbI_(3)intermediate phase assisted sequential(IPAS)deposition is successfully carried out to fabricate MA-free quasi-2D ACI perovskites.The amount of theδ-CsPbI_(3)intermediate phase in the PbI2 layer and the concentration of GAI molecule in the IPA solution both play important roles in the production of MA-free quasi-2D ACI perovskite films.The n value of the MA-free quasi-2D ACI perovskites can be adjusted,which affects the photovoltaic performance and device stability.Compared with one-step deposition,the MA-free quasi-2D ACI perovskites prepared via IPAS deposition have opposite reverse-graded QW distribution and improved vertical orientation,leading to a remarkable PEC of up to 18.86%and allowing the preparation of unpackaged devices with prominent working stability(80%,400 h).The underlying mechanism and crystallization pathway of IPAS deposition confirm that sequential deposition has unique superiority in regulating the QW distribution and crystalline orientation of quasi-2D perovskites. | Shaofu Wang Yumin Liu Junjie Zou Junjun Jin Yun Jiang Tao Zeng Wenyan Zhao Rong-Xiang He Bolei Chen Yu Chen Shuoxue Jin Hong-Xiang Li Zhipeng Xie Chang-An Wang Weiwei Sun Qiang Cao Xing-Zhong Zhao | 2023 | InfoMat2023，5，3： | 0 |
| 18 | Interplay between the atomic structures and superconductivity of two-monolayer Pb films显示文摘Superconductors with reduced dimensionality have been widely explored for their exotic superconducting behaviors.Especially,at the two-dimensional limit,two-monolayer Pb films with two types of structures provide an ideal platform to unveil the underlying superconducting mechanism[Science 324,1314(2009)].Here,by combining scanning tunneling microscopy(STM)with the first-principle calculations,we successfully identify that these two types have different atomic lattice structures with varying stacking phases,which further enables us to calculate the phonon spectrum and electron phonon coupling strength of each type.The theoretical calculations are in good agreement with tunneling spectroscopy measurements of the superconducting transition temperatures(T_(c)),which established a correlation between atomic structures and superconductivity.Moreover,it was observed that the higher T_(c)of these two types also possess higher out-of-plane upper critical magnetic fields(Hc2).These findings will provide important new insights into two-dimensional superconductivity at the atomic level. | Kun Xie Ze Huang Pengju Li Yumin Xia Desheng Cai Yitong Gu Yuzhou Liu Fangliang Cai Runxiao Zhang Haohao Shi Ping Cui Shengyong Qin | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，1： | 0 |
| 19 | A Threshold Scheme under Peer-to-Peer Network显示文摘Resource sharing among peers is one of important application in Peer-to-Peer(P2P) network. Inexistence of server makes P2P network to be a less trustable tool for property owners to distribute their resource. In order to protect intelligent property, reputation management strategy is adopted in many P2P network. As long as a P2P network reputation strategy is confirmed, application designer can employ a special detailed distribution scheme to fulfill content distribution within the net. Shmir (k,n) threshold scheme, for example, is an encryption scheme to enhance the distribution security of this kind of design. (k,n) threshold scheme is a new tool similar to Shmir scheme is proposed in this paper. The new scheme based on polynomial expansion and its security is decided by the one way function used in the secret distribution procedure. The scheme efficiency and its features as well as comparison between new and Shmir scheme are also discussed in this paper. | XIE Yumin SHI Feng MING Yang MUHAMMAD Kamran XU Jianqiang | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 0 |
| 20 | Multi-Seed Key Distribution Scheme Test显示文摘The key problem of securing multicast is to generate, distribute and update Session Encryption Key(SEK). Polynomial expansion with multi-seed(MPE) scheme is an approach which is based on Polynomial expansion(PE) scheme and overcomes PE’s shortage. Its operation is demonstrated by using multi-seed, the group member is partitioned to many subgroups. While updating the SEK, computation is needed only in one of subgroups, the other of them will use the computation history to update their SEK. The key problems to design a MPE scheme application includes to find a feasible one way function as well as to generate a Strict Prime Number(SPN). Those technologies with multi-seed and computation history concepts make MPE as a good choice in practical applications. A prototype test system is designed and solutions of all above mentioned problems are included in this proposed paper. | XIE Yumin SHI Feng MING Yang Muhammad Kamran YANG Xiaoxu | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 0 |
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