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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Biomarkers for the diagnosis of Alzheimer's disease, dementia Lewy body, frontotemporal dementia and vascular dementia显示文摘Background Dementia is a chronic brain disorder classified by four distinct diseases that impact cognition and mental degeneration. Each subgroup exhibits similar brain deficiencies and mutations. This review will focus on four dementia subgroups: Alzheimer's disease, vascular dementia, frontotemporal dementia and dementia Lewy body. Aim The aim of this systematic review is to create a concise overview of unique similarities within dementia used to locate and identify new biomarker methods in diagnosing dementia. Methods 123 300 articles published after 2010 were identified from PubMed, JSTOR, WorldCat Online Computer Library and PALNI (Private Academic Library Network of Indiana) using the following search items (in title or abstract):'Neurodegenerative Diseases' OR 'Biomarkers' OR 'Alzheimer's Disease' OR 'Frontal Temporal Lobe Dementia' OR 'Vascular Dementia, OR 'Dementia Lewy Body' OR 'Cerebral Spinal Fluid' OR 'Mental Cognitive Impairment'. 47 studies were included in the qualitative synthesis. Results Evidence suggested neuroimaging with amyloid positron emission tomography (PET) scanning and newly found PET tracers to be more effective in diagnosing Alzheimer's and amnesiac mental cognitive impairment than carbon-11 Pittsburgh compound-B radioisotope tracer. Newly created methods to make PET scans more accurate and practical in clinical settings signify a major shift in diagnosing dementia and neurodegenerative diseases. Conclusion Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics. Neuroimaging with amyloid PET scanning surpasses what had been considered the dominant method of neuroimaging and MRI. Newly created methods to make PET scans more accurate and practical in clinical settings signify a major shift in diagnosing dementia pathology. Continued research and studies must be conducted to improve current findings and streamline methods to further subcategorise neurodegenerative disorders and diagnosis. | Joshua Marvin Anthony Maclin Tao Wang Shifu Xiao | 2019 | General Psychiatry2019，32，1： | 14 |
| 3 | Recent research about mild cognitive impairment in China显示文摘 | Yan CHENG Shifu XIAO | 2014 | 上海精神医学2014，26，1： | 10 |
| 4 | Proteomic analysis of the cerebrospinal fluid of Parkinson's disease patients显示文摘 | Jiguang Guo Zhongwu Sun Shifu Xiao Dong-ping Liu Guohua Jin Ersong Wang JiangningZhou Jiawei Zhou | 2009 | Cell Research2009，19，12： | 5 |
| 5 | Parallel computing study for the large-scale generalized eigenvalue problems in modal analysis显示文摘In this paper we study the algorithms and their parallel implementation for solving large-scale generalized eigenvalue problems in modal analysis.Three predominant subspace algorithms,i.e.,Krylov-Schur method,implicitly restarted Arnoldi method and Jacobi-Davidson method,are modified with some complementary techniques to make them suitable for modal analysis.Detailed descriptions of the three algorithms are given.Based on these algorithms,a parallel solution procedure is established via the PANDA framework and its associated eigensolvers.Using the solution procedure on a machine equipped with up to 4800processors,the parallel performance of the three predominant methods is evaluated via numerical experiments with typical engineering structures,where the maximum testing scale attains twenty million degrees of freedom.The speedup curves for different cases are obtained and compared.The results show that the three methods are good for modal analysis in the scale of ten million degrees of freedom with a favorable parallel scalability. | FAN XuanHua CHEN Pu WU RuiAn XIAO ShiFu | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 4 |
| 6 | Bifurcation and buckling analysis of a unilaterally confined self-rotating cantilever beam显示文摘包括受到单方的锁或开的限制的一根自我旋转的伸臂横梁的一个简单 non-holonomic 系统的一个非线性的动态模型被采用一般哈密尔顿的变化原则建立。临界数值,小平衡在失去它的稳定性或单方的限制被激活或僵绳节点分叉发生,并且 equilibria 被近似分析、数字的方法调查。结果显示弄弯的 equilibria 和横梁的分叉模式是不同的取决于单方的限制的清理的距离是否等于零并且单方的限制是否被锁。单向性的猛咬彻底地现象(即大祸现象) 被注定发生在系统不管限制是否是锁能。僵绳节点分叉能仅仅在单方的限制是能的锁,它的清理是非零的条件上发生。二个方法获得的结果是一致的。 | Shifu Xiao Bin Chen Min Yang | 2006 | Acta Mechanica Sinica2006，22，2： | 4 |
| 7 | Study of brain morphology change in Alzheimer’s disease and amnestic mild cognitive impairment compared with normal controls显示文摘Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD. | Huanqing Yang Hua Xu Qingfeng Li Yan Jin Weixiong Jiang Jinghua Wang Yina Wu Wei Li Cece Yang Xia Li Shifu Xiao Feng Shi Tao Wang | 2019 | General Psychiatry2019，32，2： | 3 |
| 8 | Patient with frontal-variant syndrome in early-onset Alzheimer's disease显示文摘The clinical manifestation of frontal-variant Alzheimer’s disease(fvAD)is not typical,and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia(fvFD).We describe a patient with early-onset Alzheimer's disease(AD)who presented with an fvFTD-like syndrome and apolipoprotein E ε3/ε4 genotype.A brain amyloid imaging procedure,11 C-Pittsburgh compound B positron emission tomography(PET),supported the final diagnosis of AD.Our present case highlights the clinical variability that characterises early-onset AD.A multimodal approach is crucial when assessing rare forms of dementia. | Han Cai Su Ning Wei Li Xia Li Shifu Xiao Lin Sun | 2020 | General Psychiatry2020，33，2： | 2 |
| 9 | Association between tea consumption and cognitive function in cognitively healthy older adults and older adults with mild cognitive impairment显示文摘Background Prospective studies suggest that tea consumption may decrease the risk for cognitive impairment in late life.However,little research has examined the association between tea consumption and cognitive performance across multiple domains.In addition,no research has examined the benefit of tea consumption on cognitive performance among older adults with existing impairment.Aims The current study examined the association between tea consumption and performance on tasks of global cognitive function,episodic memory and executive function in cognitively healthy(CH)older adults and older adults with mild cognitive impairment(MCI).Methods The analytical sample included 1849 community-dwelling older adults from the Shanghai Brain Aging Study(65.6%female,mean age of 69.50(8.02)years).Following ascertainment of cognitive function,816 were categorised as MCI.In addition to completion of a demographics questionnaire,participants reported their tea consumption and completed a battery of tests to measure global cognitive function,episodic memory and working memory.Results Independent analyses of covariance revealed a significant association between tea consumption and measures of episodic memory;however,these associations were restricted to CH older adults but not older adults with MCI.Tea consumption was not associated with working memory performance.Conclusions The current study suggests that the benefit of tea consumption is restricted to cognitively healthy older adults and does not extend to older adults with MCI. | Hua Xu Alexandra J Fiocco Xiaohua Liu Tao Wang Guanjun Li Shifu Xiao the research group of Shanghai Brain Aging Study | 2021 | General Psychiatry2021，34，4： | 2 |
| 10 | Relationship between afternoon napping and cognitive function in the ageing Chinese population显示文摘Background Several studies have shown that afternoon napping promotes cognitive function in the elderly;on the other hand,some studies have shown opposite results.This current study further examined the relationship between afternoon napping and cognitive function in the ageing Chinese population.Methods A total of 2214 elderly were included(napping group:n=1534;non-napping group:n=680).They all received cognitive evaluations by the Beijing version of the Montreal Cognitive Assessment,the Mini-Mental State Examination,and the Chinese version of the Neuropsychological Test Battery.Among all the subjects,739 elderly volunteered to take blood lipid tests.Results Significant differences in cognitive function and blood lipids were observed between the napping and the non-napping groups.Afternoon napping was associated with better cognitive function including orientation,language,and memory in the present study.Subjects with the habit of afternoon napping also showed a higher level of triglyceride than the non-napping subjects.Conclusion The results demonstrated that afternoon napping was related to better cognitive function in the Chinese ageing population. | Han Cai Ning Su Wei Li Xia Li Shifu Xiao Lin Sun | 2021 | General Psychiatry2021，34，1： | 2 |
| 11 | ACE gene missense mutation in a case with early-onset, rapid progressing dementia显示文摘The population of early-onset Alzheimer's disease(EOAD)accounts for 1%-2%of the total population of Alzheimer's disease,and genetic mutations are more common in EOAD.The first symptom of the patient in the present case report was the decline in memories of recent events,and the disease progressed rapidly in the following 2 years.Genetic testing has revealed the presence of genetic mutations(c.A479G,p.N160S)of ACE,which causes the 160th codon of the ACE protein to change from aspartic acid to serine,and at the same time genotype of apolipoprotein E(APOE)is ε3/ε4.We think that this patient carries the mutation type of the sensitive gene ACE and the risk gene APOE of Alzheimer's disease,and this is the reason why the disease progressed rapidly.Moreover,we discussed ACE genetic mutation's meaning in EOAD progression. | Jing Ni Shifu Xiao Xia Li Lin Sun | 2019 | General Psychiatry2019，32，5： | 1 |
| 12 | Suicide among the elderly in mainland China显示文摘 | Li Xia Zeping Xiao Shifu Xiao | | 0，，02： | 1 |
| 13 | Suicide among the elderly in mainland China显示文摘 | Xia LI Zeping XIAO Shifu XIAO | 2009 | Psychogeriatrics2009，，： | 1 |
| 14 | Recent development in the study of prevalence and phenomenology of neurasthenia in general health care across cultures显示文摘 | Xiao Shifu Yan Heqin Michael Linden | 1998 | Hong Kong Journal of Psychiatry1998，8，1： | 1 |
| 15 | Are the revised diagnostic criteria for Alzheimer's disease useful in low- and middle-income countries?显示文摘 | Cece YANG Shifu XIAO | 2015 | 上海精神医学2015，27，2： | 1 |
| 16 | Efficacy of comprehensive cognitive health management for Shanghai community older adults with mild cognitive impairment显示文摘Background The management of modifiable risk factors and comorbidities may impact the future trajectory of cognitive impairment,but easy-to-implement management methods are lacking.Aims This study investigated the effects of simple but comprehensive cognitive health management practices on the cognitive function of older adults in the community with normal cognition(NC)and mild cognitive impairment(MCI).Methods The comprehensive cognitive health management programme included a psychiatric assessment of the cognitive risk factors for those in the intervention groups and individualised recommendations for reducing the risks through self-management supported by regular medical professional follow-up.The intervention groups for this study included 84 elderly participants with NC and 43 elderly participants with MCI who received comprehensive cognitive health management.The control groups included 84 elderly participants with NC and 43 elderly participants with MCI who matched the intervention group’s general characteristics and scale scores using the propensity matching score analysis.The Montreal Cognitive Assessment(MoCA)scale and Geriatric Depression Scale(GDS)scores were compared after a 1-year follow-up.Results For older adults with MCI in the intervention group,MoCA scores were higher at the 1-year followup than at baseline(24.07(3.674)vs 22.21(3.052),p=0.002).For the MoCA subscales,the intervention group’s abstract and delayed memory scores had significantly increased during the 1-year follow-up.Furthermore,in a generalised linear mixed model analysis,the interaction effect of group×follow-up was statistically significant for the MCI group(F=6.61,p=0.011;coefficients=5.83).Conclusions After the comprehensive cognitive health management intervention,the older adults with MCI in the community showed improvement at the 1-year follow-up.This preliminary study was the first to demonstrate an easy-to-implement strategy for modifying the cognitive risk factors of elderly individuals with MCI in the community,providing new insight into early-stage intervention for dementia. | Jiayuan Qiu Lu Zhao Shifu Xiao Shaowei Zhang Ling Li Jing Nie Li Bai Shixing Qian Yang Yang Michael Phillips Meiqing Sheng Yuan Fang Xia Li | 2022 | General Psychiatry2022，35，4： | 0 |
| 17 | BRIEF COMMUNICATION ARISING Geng et al.reply显示文摘The accompanying comment by Dr.Rao,suggests that there is an omission of citation of 12 previous publications in our Wang et al.paper.1 We disagree with the suggestion for the following reasons.We believe that the 12 publications cited by Dr.Rao do not have sufficient relevance to the Wang et al.paper.1 The past decades have witnessed an explosive growth in our understanding of the pathogenesis of Alzheimer's disease(AD),which is a very complicated process.The Wang et al. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2020 | Cell Research2020，30，9： | 0 |
| 18 | Psychometric properties of the Chinese version of the Arabic Scale of Death Anxiety显示文摘背景:死亡焦虑被视为精神病理学症状的风险因素和持续存在的因素。虽然阿拉伯死亡焦虑量表(ASDA)是一种简单而常用的评估工具,但是在国内临床实践中缺少这样的工具。目标:本研究旨在采用多级回译法开发ASDA中文版,即ASDA(C),并研究该量表的心理测量学特性。方法:从国内三个地区的医院和大学共招募了1372名参试者。为了计算出ASDA(C)的效标相关效度与有关死亡和死亡清单的多维度取向表格中文版(MODDI-F/chin)相比较,随机指定49名大学生完成这两份调查问卷。在所有参试者中随机指定56名再做一次ASDA(C)问卷调查,来评估ASDA(C)的一周后重测信度。结果:量表总的Cronbach’sα值为0.91。一周后的重测信度为0.96。探索性因子分析(EFA)显示三个因素,'对死人和坟墓的恐惧,'对致命疾病的恐惧'和'对死亡事件的恐惧',占总方差的57.09%。因而构建三因素模型。量表ASDA(C)总分与MODDI-F/chin的相关系数是0.54,表示信度都可以接受。结论:ASDA(C)有较好的心理测量学特性,说明这是一个可靠有效的量表。该量表能用于讲普通话的中国人群,来评估死亡焦虑。 | Qi QIU Shengyu ZHANG Xiang LIN Chunxia BAN Haibo YANG Zhengwen LIU Jingrong WANG Tao WANG Shifu XIAO Ahmed M ABDEL-KHALEK Xia LI | 2016 | 上海精神医学2016，28，3： | 0 |
| 19 | Case of early-onset Alzheimer’s disease with atypical manifestation显示文摘Short-term memory decline is the typical clinical manifestation of Alzheimer’s disease(AD).However,early-onset AD usually has atypical symptoms and may get misdiagnosed.In the present case study,we reported a patient who experienced symptoms of memory loss with progressive non-fluent aphasia accompanied by gradual social withdrawal.He did not meet the diagnostic criteria of AD based on the clinical manifestation and brain MRI.However,his cerebrospinal fluid examination showed a decreased level of beta-amyloid 42,and increased total tau and phosphorylated tau.Massive amyloid β-protein deposition by 11C-Pittsburgh positron emission tomography confirmed the diagnosis of frontal variant AD.This case indicated that early-onset AD may have progressive non-fluent aphasia as the core manifestation.The combination of individual and precision diagnosis would be beneficial for similar cases. | Lin Zhu Limin Sun Lin Sun Shifu Xiao | 2021 | General Psychiatry2021，34，1： | 0 |
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