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| 1 | Salt stress and comparative physiology in the Gramineae显示文摘 | WYN J R G | 1978 | Australia Journal of Plant Physiology1978，5，： | 1 |
| 2 | Effect of exogenous glycinebetaine on Na+ transport in barley roots显示文摘 | Wyn Jones R G Jeschke W D | 1987 | J Exp Bot1987，38，： | 1 |
| 3 | Enzyme activities in concentrated solu-tions of giycinebetaine and other solutes显示文摘 | Pollard A Wyn Jones R G | 1979 | Planta1979，144，3： | 1 |
| 4 | A hypothesis relating critical po- tassium concentrations for growth to the distribution and func- tions of this ion in the plant cell显示文摘 | Leigh R A Wyn Jones R G | 1984 | New Phytologist1984，97，： | 1 |
| 5 | Bright SWJ Influence of proline and glyeinrbetaine on salt tolerance of cultured barley embryos显示文摘 | Lone M I KuehJ S H Wyn Jones R G | 1987 | Journal of Exper imental Botany1987，38，： | 1 |
| 6 | A hypothesis relating critical potassium concentrations for growth to the distribution and functions of this ion in the plant cell显示文摘 | Leigh R A Wyn J R G | 1984 | New Phytology1984，97，： | 1 |
| 7 | Some mechanisms of salt tolerance in crop plants显示文摘 | Gorham J Wyn R G Mcdonnel E | 1985 | Plant Soil1985，89，： | 1 |
| 8 | Solute distribution in Suaeda maritime显示文摘 | Gorham J Wyn Jones R G | 1983 | Planta1983，157，： | 1 |
| 9 | Enzyme activities in concentrated solutions of glycinebetaine and other solutes显示文摘 | Pollard A Wyn J R G | 1979 | Planta1979，144，： | 1 |
| 10 | Phytochemical aspects of osmotic adaptation显示文摘 | WYN J R G | 1984 | Recent Adv Phytochem1984，18，： | 1 |
| 11 | Effect of rhizosphere pH on the availability and uptake of Fe, Mn, and Zn显示文摘 | SARKAR A N WYN JONES R G | 1982 | Plant and Soil1982，66，： | 1 |
| 12 | Enzyme activities in concentrated solutions of glycinebetaine and other solutes显示文摘 | POLLARD A WYN JONES R G | 1979 | Planta1979，144，： | 1 |
| 13 | Determination of betaines as ultraviolet-absorbing esters显示文摘 | GORHAM J Mcdonnell E Wyn J R G | 1982 | Anal Chim Acta1982，138，： | 1 |
| 14 | The pharmacokinetics of paliperidone versus?risperidone显示文摘 | De Leon J Wyn G Sandson NB | 2010 | Psychosomatics2010，51，1： | 1 |
| 15 | Human epidermal growth factor receptor-2 in oesophageal cancers:An observational study显示文摘AIM:To determine the incidence of human epidermal growth factor receptor 2(HER2) over expression in oesophageal cancers.METHODS:A retrospective study,of one hundred consecutive cases of endoscopic histological samples of oesophageal cancers from a single British cancer network were included.Cancer cases were diagnosed between April 2007 and June 2010.HER2 over expression was assessed using immunohistochemistry,those that scored '0' and '+1' were considered 'negative' for HER2;those that scored '+3' were considered 'Positive'.Cases that were scored '+2' on immunohistochemistry further went on to have HER2 gene analysis using the Ventana HER brightfield dual-colourin situ hybridisations(HER B DISH) assay and either came back to be positive or negative for HER2 over expression.Overall survival was measured from date of histological diagnosis until date of death.93% of the cases were followed up till five years or death,and all were followed up till two years.Cases of gastro-oesophageal junctional tumours were excluded.RESULTS:The median age of our sample was 66 years(range:38-91 years).Eighty one were male and 19 female.Ninety-one of the cases were adenocarcinoma of the oesophagus and the rest were cases of squamous cell carcinoma.The anatomical distribution of the tumours was;upper oesophagus 2,middle oesophagus 11,and 87 were in the lower oesophagus.Operative resection was completed in 15 cases;seven cases had attempted surgical resections,i.e.,open and close,33 patients received definitive chemo-radiation and 52 had palliative treatment.Twenty-five of the cancers showed evidence of HER2 over expression,all were adenocarcinomas.Of the 25 cases that showed evidence of HER2 over expression,21(84%) were located in the lower third of the oesophagus.On staging,24 out of the 25 HER2 positive cases were at stage 3 or more(13 at stage 3 and 11 at stage 4),For HER2 negative cases 37 were at stage 3 and 32 were staged as stage 4.Seventeen out of twenty five cases(68%) with HER2 over expression received palliative therapy,in comparison to thirty five out of seventy five(46.7%) in tumours not expressing HER2.No significant difference in overall survival was demonstrated between patients whose cancers showed evidence of HER2 over expression and those who did not;median overall survival for HER2 positive tumours was 15 mo(95%CI,11-19 mo) compared to 13 mo(95%CI,9-17 mo) for HER2 negative ones.Two years cumulative survival for cases with HER2 over expression was 33.7% compared to 31.6% in cases without HER2 over expression(P = 0.576).Only cancer's stage significantly affected overall survival on both univariant and multivariable analysis(P = 0.034 and P = 0.009 respectively).None of the patients included in this study received Trastuzumab.CONCLUSION:Twenty-seven point five percent of oesophageal adenocarcinomas showed evidence of HER2 over expression.Routine testing for human HER2 in oesophageal adenocarcinomas can have significant implication on treatments offered to patients that may potentially affect their prognosis. | Hazem Al-Momani Rachel Barnes Ahmed El-Hadi Rachit Shah Wyn G Lewis Paul Edwards | 2012 | World Journal of Gastroenterology2012，18，44： | 1 |
| 16 | A hypothesis relating critical potassium concentrations for growth to the distribution and function of this ion in the plant cell显示文摘 | LEIGH R A WYN JONES R G | 1984 | New Phytol1984，97，1： | 1 |
| 17 | Salt tolerance in the Triticeae: Growth and solute accumulation in leaves of Thinopyrum bessarabicum显示文摘 | Goham J McDonnell E Budreuiez E Wyn Jones R G | 1985 | Journal of Experimental Botany1985，36，： | 1 |
| 18 | Cubic phaseformation iu polar nouaqueous solveuts 显示文摘 | BLEASDALE T A TIDDY G J T WYN - JONES E | 1991 | The Journal of Physical Chemistry1991，95，： | 1 |
| 19 | Effect of rhizosphere pH on the availability and uptake ofFe, Mn and Zn显示文摘 | SARKER A N WYN J R G | 1982 | Plant Soil1982，66，： | 1 |
| 20 | Chromosomal location of a K + / Na + discrimination character in the genome of wheat 显示文摘 | Gorham J Hardy C Wyn Jones R G | 1987 | TAG1987，74，： | 1 |
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