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| 1 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 17 |
| 2 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 3 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 4 | The design features of the HTR-10显示文摘 | Wu ZX | 2002 | Nucl Eng Design2002，218，： | 1 |
| 5 | Advanced oxidation protein productsin diabetic nephropathy patients and its relation with superoxidedismutase,glutathione peroxidase,neopterin显示文摘 | Wu ZX Xue YM Li CZ | 2005 | J Central South Univ(Med Sci)2005，30，： | 1 |
| 6 | A comparison of 2 types of chest compressions in a porcine model of cardiac arrest显示文摘 | Wu JY Li CS Liu ZX | 2009 | Am J Emerg Med2009，27，7： | 1 |
| 7 | Biomechanical evaluation of an expansive pedicle screw in calf vertebrae显示文摘 | Lei W Wu ZX | 2006 | Eur Spine J2006，15，3： | 1 |
| 8 | Traditional chinese medicine syndrome distribution in chronic hepatitis B populations:a systematic review显示文摘 | Zeng XX Bian ZX Wu TX | 2011 | Amer J Chin Med2011，39，6： | 1 |
| 9 | Biomechanical comparison of differ- ent techniques in primary spinal surgery in osteoporotic cadaveric lumbar vertebrae: expansive pedide screw versus polymethylmethae- rylate - augmented pedicle screw 显示文摘 | Liu D Wu ZX Pan XM | 2011 | Arch Orthop Trauma Surg2011，9，： | 1 |
| 10 | Endovascular treatment of giantand large intracranial aneurysms using the neuroform stent-assisted coil placement 显示文摘 | Yang X J Wu ZX Mu SQ | 2008 | Neuroradiol Res2008，30，： | 1 |
| 11 | Coadministration of Pinellia ternate Can Significantly Reduce Aconitum carmichaeliito Inhibit CYP3A Activity in Rats显示文摘 | Wu JJ Cheng ZX Zhu LJ | 2014 | EvidBased Complement Alternat Med2014，，10： | 1 |
| 12 | Fragmentation study of simvastatin and lovastatin using electrospray ionization tandem mass spectrometry显示文摘 | Wang H Wu YH Zhao ZX | 2001 | J Mass Spectrom2001，36，1： | 1 |
| 13 | Peritumoral edema on magnetic resonance imaging predicts a poor clinical outcome in malignant glioma显示文摘 | Wu CX Lin GS Lin ZX | 2015 | Oncol Lett2015，10，5： | 1 |
| 14 | Dot - immunogold - silver staining in the diagnosis of cystieercosis显示文摘 | Liu YS Du WP Wu ZX | 1996 | Int J Parasitol1996，26，1： | 1 |
| 15 | A new method of partial screw aug- mentation in sheep vertebrae in vitro:biomechanical and interfacial e- valuation显示文摘 | Liu D Wu ZX Gao MX | 2011 | J Spinal Disord Tech2011，24，5： | 1 |
| 16 | GABAergic mechanisms of heroin- induced brain activation assessed with functional MRI 显示文摘 | Xi ZX Wu G Steim EA | 2002 | Magn Reson Med2002，48，5： | 1 |
| 17 | RNA interference targeting virion core protein ORF095 inhibits Goatpox virus replication in vero cells显示文摘 | Zhao ZX Wu GH Zhu XL | | 0，，： | 1 |
| 18 | A new rat model for diffuse axonal injury using a combination of linear acceleration and angular acceleration显示文摘 | Wang HC Duan ZX Wu FF | 2010 | J Neurotrauma2010，27，： | 1 |
| 19 | Advanced oxidation protein products in diabetic nephropathy patients and its relation with superoxide dismutase, glutathione peroxidase, neopterin显示文摘 | Wu ZX Xue YM Li CZ | 2005 | J Central South Univ(Med Sci)2005，30，6： | 1 |
| 20 | Study on the influence factors of neonatal CRP显示文摘 | Hua SD An SL Wu ZX | 2012 | Health Med2012，6，1： | 1 |
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