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| 1 | 基于GRACE时变重力场的三峡水库补给水系水储量变化显示文摘利用22个月的GRACE时变重力场,反演了三峡水库补给水系的水储量变化,并按月给出了数值结果.与水文学同化模型(CPC)的两组比较说明基于GRACE重力的反演结果是合理的.当高斯平均半径为1000km时,该区总水储量变化的峰谷差为14cm,其年变化振幅为5.8cm,相位为-40.8天,与CPC模型合成重力数据的反演结果进行比较,其总水储量变化均方差为1.3cm,年变化振幅相差0.1cm,相位相差1.0天.为进一步检验GRACE能否监测该区真实水储量变化,还将其反演结果与CPC模型的真实平均结果进行比较,结果发现总体均方差为2.1cm,年变化振幅相差1.7cm,相位相差9.3天.因此,第一种比较过高地估计了GRACE监测该区水储量变化的能力,第二种比较则较真实地反映了实际情况,尽管反演结果与水文学的结果差别较大,但仍然显示GRACE能监测该区每月的水储量变化. | 汪汉胜 王志勇 袁旭东 Wu Patrick @Rangelova Elena Rangelova Elena | 2007 | 地球物理学报2007，50，3： | 48 |
| 2 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 3 | Early Cenozoic Mega Thrusting in the Qiangtang Block of the Northern Tibetan Plateau显示文摘最近的印射和地震调查表明集中的压缩在在中央西藏的高原的 Qiangtang 块的早新生代期间形成了移动的戳表的广泛的建筑群沿着几个通常蘸北方的伟人相对向南方戳系统。那些在 450 km 的边阶宽块表演它制服拉萨块到南方并且被 Hohxil-Bayanhar 块制服到北方。系统主要是薄皮的与合拢联系使戳成鳞状。戳表主要是由显然在三叠纪的沙岩和页岩上滑动了的侏罗记石灰石的 floored,它局部地被包括,并且 ramped 向上并且过去古新始新世红床。在形成的古生代的变形岩石,二叠的碳酸盐和花岗石上面更深、带的铲起的一些中央戳一中央高举那把 Qiangtang 块划分成二部分。这些系统和他们的联系结构被很少 unconformably 覆盖使晚始新世渐新世的暴烈的岩石变形了或由中新世的湖床盖住。A 在邻近的拉萨块的北部分在块,以及块的北部分插入了系统,蘸到南方并且看起来由于在戳床单以内的第二等的调整。 | WU Zhenhan YE Peisheng Patrick J.BAROSH HU Daogong LU Lu ZHANG Yaoling | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 23 |
| 4 | International consensus statement on robotic hepatectomy surgery in 2018显示文摘The robotic surgical system has been applied in liver surgery. However,controversies concerns exist regarding a variety of factors including the safety,feasibility, efficacy, and cost-effectiveness of robotic surgery. To promote the development of robotic hepatectomy, this study aimed to evaluate the current status of robotic hepatectomy and provide sixty experts' consensus and recommendations to promote its development. Based on the World Health Organization Handbook for Guideline Development, a Consensus Steering Group and a Consensus Development Group were established to determine the topics, prepare evidence-based documents, and generate recommendations. The GRADE Grid method and Delphi vote were used to formulate the recommendations. A total of 22 topics were prepared analyzed and widely discussed during the 4 meetings. Based on the published articles and expert panel opinion, 7 recommendations were generated by the GRADE method using an evidence-based method, which focused on the safety, feasibility, indication,techniques and cost-effectiveness of hepatectomy. Given that the current evidences were low to very low as evaluated by the GRADE method, further randomized-controlled trials are needed in the future to validate these recommendations. | Rong Liu Go Wakabayashi Hong-Jin Kim Gi-Hong Choi Anusak Yiengpruksawan Yuman Fong Jin He Ugo Boggi Roberto I Troisi Mikhail Efanov Daniel Azoulay Fabrizio Panaro Patrick Pessaux Xiao-Ying Wang Ji-Ye Zhu Shao-Geng Zhang Chuan-Dong Sun Zheng Wu Kai-Shan Tao Ke-Hu Yang Jia Fan Xiao-Ping Chen | 2019 | World Journal of Gastroenterology2019，25，12： | 23 |
| 5 | 冰川均衡调整(GIA)的研究显示文摘冰川均衡调整对固体地球物理学、大地测量学、地貌学、海洋学、冰川学、气候变化、水资源、天文学和考古学等学科具有重要的意义,通过其综述性介绍,以吸引我国地学界的注意和兴趣.本文结合作者和国内外研究成果,全方位地阐述了冰川均衡调整研究的完整内涵,首先给出了冰川均衡调整的完整概念,探讨了冰川均衡调整对冰后地壳运动、全球海平面变化、地球重力场、地球旋转运动和应力状态的影响,再分析了冰川均衡调整研究的科学目标和冰川均衡调整研究的历史与现状,最后指出了冰川均衡调整研究的未来发展方向. | 汪汉胜 WU Patrick 许厚泽 | 2009 | 地球物理学进展2009，24，6： | 21 |
| 6 | 大地测量观测和相对海平面联合约束的冰川均衡调整模型显示文摘利用大地测量和历史相对海平面变化数据,结合地震剪切波层析模型,联合确定了新的末次冰期冰川均衡调整(GIA)模型,其中地慢黏滞度不仅沿径向而且沿横向变化.研究思路是,先尝试性地选择比例系数β,利用与地震剪切波速异常的线性关系,计算地幔黏滞度横向扰动,并与横向均匀的黏滞度参考模型叠加给出3D地慢黏滞度模型;再利用耦合拉普拉斯方程的有限元法算法进行GIA预测;然后,重复该过程,直到预测与观测之间的吻合满意为止.主要结论有:(1)给出了横向非均匀的地幔黏滞度模型(RF3L20(β=0.4)),发现了黏滞度显著的横向非均匀性和其对GIA预测的显著影响,指出横向非均匀不完全是由热效应引起的,可能还与化学组分等其他因素有关,该模型可用于地慢动力学研究.(2)给出了全球现今多种GIA预测速率,可为板块运动、陆地水储量、海水质量变化和冰川冰雪质量非平衡监测提供重要的改正. | 汪汉胜 WU Patrick van der Wal Wouter 贾路路 胡波 王志勇 | 2009 | 地球物理学报2009，52，10： | 17 |
| 7 | 冰川均衡调整对东亚重力和海平面变化的影响显示文摘新的全球冰川均衡调整(GIA)模型RF3L20(β=0.4)+ICE-4G考虑了地幔黏滞度沿横向的变化,其黏滞度参数得到大地测量、历史相对海平面变化观测和地震剪切波层析模型的较好约束.本文利用该模型预测了东亚现今重力变化和海平面变化,根据当前末次冰川时空变化和黏滞度参考模型中下地幔下部黏滞度认识的差异,评估了预测的不确定性.结果表明,GIA对东亚地区重力场和海平面长期变化有显著的影响:例如,在哈尔滨、长春、泰安、蓟县、郑州、武汉等测站,GIA重力影响达几十纳伽,可用超导重力仪和未来原子重力仪观测出来;在东亚大陆GIA对GRACE监测的等效水柱长期变化的影响为3%~10%,其中青藏高原西部、华北和三峡地区的影响较大.在东海—太平洋区,GIA的相对影响高达20%~40%;GIA使东亚海域绝对海平面以0.27~0.37mm/a的速率在长期下降,在黄海、东海卫星测高监测的绝对海平面长期变化中,GIA的相对影响分别达6.9%和7.5%;在58个验潮站,平均相对海平面长期上升速率为2.22mm/a,GIA影响为—0.17mm/a,其中14个测站GIA的影响达—0.3~—0.4mm/a.本文GIA预测的结果,对在东亚地区发现弱的地球动力学过程信号、监测水质量长期变化、监测海平面长期变化和分析其机制,提供精密的改正模型. | 汪汉胜 贾路路 WU Patrick 胡波 | 2010 | 地球物理学报2010，53，11： | 16 |
| 8 | 冰川均衡调整对南极冰质量平衡监测的影响及其不确定性显示文摘本文研究了新的全球冰川均衡调整(GIA)模型对南极冰盖质量平衡监测的影响,考虑现有冰川负荷模型和地幔黏滞度模型的差异,完整评估了结果的不确定性,最后结合GRACE和卫星测高的结果进行了对比分析.结果表明,GIA对GRACE监测的等效水柱变化有重大影响,较大的GIA影响出现在西南极,沿罗斯冰架-卡姆布冰流-罗尼冰架-南极半岛分布,最大值在卡姆布冰流,达到29.8 mm/a;GIA对南极整体冰质量平衡的影响达到134±28 Gt/a.在不确定性的方差中,西南极和东南极分别以冰负荷模型差异和地幔黏滞度差异影响为主,对整个南极,冰模型差异影响占88.4%;在一些典型地区,GRACE监测的等效水柱在扣除GIA前后分别是,卡姆布冰流~32.8 mm/a和~6.3 mm/a,阿蒙森海湾~-95.3 mm/a和~-102.5 mm/a,Enderby Land~13.6 mm/a和~8.1 mm/a.整个南极冰盖总质量变化在扣除GIA贡献后为-82±29 Gt/a,该估计与卫星测高结果较吻合.此外,GIA对卫星测高监测的冰面高程变化的影响一般不超过8%.本研究为空间大地测量监测南极冰质量平衡提供了新的改正模型. | 贾路路 汪汉胜 相龙伟 WU Patrick 李斐 史红岭 | 2011 | 地球物理学报2011，54，6： | 15 |
| 9 | Seasonal pattern of Echinococcus re-infection in owned dogs in Tibetan communities of Sichuan, China and its implications for control显示文摘Background:Human cystic echinococcosis(CE)and alveolar echinococcosis(AE)are highly endemic in Tibetan communities of Sichuan Province.Previous research in the region indicated that domestic dog was the major source of human infection,and observations indicated that domestic dog could have more access to intermediate hosts of Echinococcus spp.:both domestic livestock(CE)viscera and small mammals(AE),in early winter and again in spring.We hypothesized that there would therefore be a significant increase in the risk of canine infection with Echinococcus spp.in these two seasons and conducted a reinfection study to investigate this further.Methods:Faecal samples were collected from owned dogs in seven townships in Ganze Tibetan Autonomous Prefecture(Sichuan Province,China),and Echinococcus spp.infection status was determined using copro-antigen ELISA.Dogs were sampled in April(spring),July(early summer),September/October(autumn/early winter)and December(winter)in 2009;and in April(spring)2010.Dogs were treated with praziquantel following each of the five sample collections to eliminate any tapeworms.Information on dog sex,age and body weight was also collected.The t-test,Fisher’s exact test,Poisson regression and logistic regression were used to compare means and prevalences,and to identify factors associated with infection status.Results:The proportion of female dogs was significantly lower than that of male dogs;female dogs had significantly higher(22.78%)baseline copro-ELISA prevalence than males(11.88%).Dog body weight,sex,age,county and previous infection status at any sampling point had no influence on the re-infection prevalence in general.Poisson regression did not found a significant influence on the re-infection prevalence due to different deworming/sampling time spans.Dogs exhibited significantly higher re-infection prevalences in spring and early summer of 2009 and in early winter between September/October and December of 2009,suggesting a higher infection pressure in these seasons comparing with other seasons.Conclusion:Following praziquantel treatment,dog body weight,sex,age,county,deworming time span and previous infection status at any sampling point had no influence on the re-infection prevalence in the region in general.The differences between re-infection prevalences were probably due to the seasonality in Echinoccocus spp.infection pressure in the region.Early winter,spring and early summer should be important seasons for optimal dog deworming intervention in these Tibetan communities. | Qian Wang Wen-Jie Yu Bo Zhong Jing-Ye Shang Liang Huang Alexander Mastin Renqingpengcuo Yan Huang Guang-Jia Zhang Wei He Patrick Giraudoux Wei-Ping Wu Philip S.Craig | 2016 | Infectious Diseases of Poverty2016，5，1： | 15 |
| 10 | A deep learning-enabled portable imaging flow cytometer for cost-effective, highthroughput, and label-free analysis of natural water samples显示文摘We report a deep learning-enabled field-portable and cost-effective imaging flow cytometer that automatically captures phase-contrast color images of the contents of a continuously flowing water sample at a throughput of 100 mL/h.The device is based on partially coherent lens-free holographic microscopy and acquires the diffraction patterns of flowing micro-objects inside a microfluidic channel.These holographic diffraction patterns are reconstructed in real time using a deep learning-based phase-recovery and image-reconstruction method to produce a color image of each micro-object without the use of external labeling.Motion blur is eliminated by simultaneously illuminating the sample with red,green,and blue light-emitting diodes that are pulsed.Operated by a laptop computer,this portable device measures 15.5 cm×15 cm×12.5 cm,weighs 1 kg,and compared to standard imaging flow cytometers,it provides extreme reductions of cost,size and weight while also providing a high volumetric throughput over a large object size range.We demonstrated the capabilities of this device by measuring ocean samples at the Los Angeles coastline and obtaining images of its micro-and nanoplankton composition.Furthermore,we measured the concentration of a potentially toxic alga(Pseudo-nitzschia)in six public beaches in Los Angeles and achieved good agreement with measurements conducted by the California Department of Public Health.The cost-effectiveness,compactness,and simplicity of this computational platform might lead to the creation of a network of imaging flow cytometers for largescale and continuous monitoring of the ocean microbiome,including its plankton composition. | Zoltán Gӧrӧcs Miu Tamamitsu Vittorio Bianco Patrick Wolf Shounak Roy Koyoshi Shindo Kyrollos Yanny Yichen Wu Hatice Ceylan Koydemir Yair Rivenson Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 14 |
| 11 | 末次冰期冰盖消融对东亚历史相对海平面的影响及意义显示文摘基于新的末次冰期冰川均衡调整(GIA)模型,利用有限元算法模拟了盛冰期以来东亚相对海平面的变化,并与观测数据进行比较分析.研究表明,早期相对海平面上升由盛冰期后全球冰盖消融控制,后期的变化则由地壳黏性均衡调整控制;每个时期的结果均具有显著的区域性差异,与地壳均衡作用及远场均衡效应的区域性差异有关;模拟的不确定性主要来自冰盖消融模型差异的影响,量级在观测误差范围内.此外,利用本文的GIA模拟结果,对东亚海岸历史相对海平面观测进行改正,揭示了华南全新世以来不同阶段的地壳垂直运动,其中3—8kaBP地壳以较稳定的速率(1~4mm/a)下沉,之后则以较小速率下降或隆升,推测可能与东南部菲律宾板块的俯冲有关;揭示近千年来粤东海岸和珠江三角洲地壳垂直运动有长期隆升趋势,而近三十年的观测结果则显示下沉,推测该差异与人类活动导致的沉降有关. | 汪汉胜 贾路路 WU Patrick 江利明 胡波 相龙伟 | 2012 | 地球物理学报2012，55，4： | 8 |
| 12 | Miocene Tectonic Evolution from Dextral-Slip Thrusting to Extension in the Nyainqentanglha Region of the Tibetan Plateau显示文摘在西藏的 Nyainqentanglha 区域的右滑倒导致了 obliqueunderthrusting 和花岗石产生在对中间早中新世,但是在时代底高举并且紧张的指责统治了的前。东方西方右滑倒 Gangdise 差错系统合并进东北趋势东方,转动东方更远的北方进右滑倒北方 Damxung 剪碎带和 Jiali 的蘸东南的 Nyainqentanglha 戳系统指责。这些差错是形成了由当西方的块不到东方的开车了,早, Miocene,和大 Nyainqentanglha 花岗石的底盘在 18.3-11.0 妈形成了戳系统。Thedextral 滑倒运动在~ 1 结束了 1 个妈和底盘玫瑰,由在 8.6-8.3 妈的重力的砍标记,一个新差错系统发展了。西北趋势右滑倒差错形成了到 raisen 底盘的西北,而有某左首滑倒的东北趋势南方 Damxung 上投断层形成了到东南。后者被 thewest-northwest-trending Lhiinzhub 上投断层被右滑倒远代替到东方。这相对本地高举让存款保存了的 Eocene 和 Miocene 邻近那被区域抬升和一个系统的开始跟随通常纵贯抓住 ens 在在~ 6 .5 晚中新世妈。Theregional 高举南部的西藏的高原因此看起来发生在 8.3 妈和 6.5Ma 之间。Gulu, Damxung-Yangbajain 和 Angan 在 NyainqentanglhaMountains 的通行证东方被更早的东北趋势差错局部地控制的系统抓住。这些抓住 ens 统治随后的构造运动并且山向西北作为西北趋势右滑倒差错仍然很活跃。Miocene 是迎来了现代构造政体的大构造变化的一时间。 | WU Zhenhan Patrick J. BAROSH ZHAO Xun WU Zhonghai HU Daogong LIU Qisheng | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 8 |
| 13 | Dextral-Slip Thrust Faulting and Seismic Events of the Ms 8.0 Wenchuan Earthquake,Longmenshan Mountains,Eastern Margin of the Tibetan Plateau显示文摘Dextral-slip thrust movement of the Songpan-Garzê terrain over the Sichuan block caused the M_s 8.0 Wenchuan earthquake of May 12,2008 and offset the Central Longmenshan Fault(CLF) along a distance of~250 km.Displacement along the CLF changes from Yingxiu to Qingchuan.The total oblique slip of up to 7.6 m in Yingxiu near the epicenter of the earthquake,decreases northeastward to 5.3 m,6.6 m,4.4 m,2.5 m and 1.1 m in Hongkou,Beichuan,Pingtong,Nanba and Qingchuan,respectively.This offset apparently occurred during a sequence of four reported seismic events,EQ1-EQ4,which were identified by seismic inversion of the source mechanism.These events occurred in rapid succession as the fault break propagated northeastward during the earthquake. Variations in the plunge of slickensides along the CLF appear to match these events.The Mw 7.5 EQ1 event occurred during the first 0-10 s along the Yingxiu-Hongkou section of the CLF and is characterized by 1.7 m vertical slip and vertical slickensides.The Mw 8.0 EQ2 event,which occurred during the next 10-42 s along the Yingxiu-Yanziyan section of the CLF,is marked by major dextralslip with minor thrust and slickensides plunging 25°-35°southwestward.The Mw 7.5 EQ3 event occurred during the following 42-60 s and resulted in dextral-slip and slickensides plunging 10°southwestward in Beichuan and plunging 73°southwestward in Hongkou.The Mw 7.7 EQ4 event, which occurred during the final 60-95 s along the Beichuan-Qingchuan section of the CLF,is characterized by nearly equal values of dextral and vertical slips with slickensides plunging 45°-50°southwestward.These seismic events match and evidently controlled the concentrations of landslide dams caused by the Wenchuan earthquake in Longmenshan Mountains. | WU Zhenhan DONG Shuwen Patrick J. BAROSH ZHANG Zuoheng LIAO Huaijun | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 8 |
| 14 | 广东全新世海平面重建与冰川均衡调整模型结果的比较显示文摘中国广东沿岸作为一个冰川均衡调整(GIA)“远场”地区,按照水动型均衡理论,应存在全新世中期高海平面。本文通过海平面标志物重建了广东古海平面的历史,结果显示出在粤东、粤西与珠江三角洲的海平面历史存在明显的差异。若将海平面历史与GIA模型结果对比,可以看出广东沿岸在全新世以来具有微小的区域性地壳沉降。这种大区域的沉降可归因于华南陆块向南延伸所引起。此外,粤西雷州半岛因新构造运动,于全新世早中期有轻微抬升。珠江三角洲盆地则因断裂构造沉降和沉积物压实作用,重建的中全新世海平面明显低于GIA结果。 | 孙奕映 Wu Patrick 黄光庆 宗永强 | 2015 | 第四纪研究2015，35，2： | 7 |
| 15 | Early Cretaceous Tectonics and Evolution of the Tibetan Plateau显示文摘Selected geological data on Early Cretaceous strata, structures, magmatic plutons and volcanic rocks from the Kunlun to Himalaya Mountains reveal a new view of the Early Cretaceous paleo-tectonics and the related geodynamic movement of the Tibetan Plateau. Two major paleooceans, the Mid-Tethys Ocean between the Qiangtang and Lhasa blocks, and the Neo-Tethys Ocean between the Lhasa and Himalayan blocks, existed in the Tibetan region in the Early Cretaceous. The Himalayan Marginal and South Lhasa Seas formed in the southern and northern margins of the NeoTethys Ocean, the Central Tibet Sea and the Qiangtang Marginal Sea formed in the southern and northern margins of the Mid-Tethys Ocean, respectively. An arm of the sea extended into the southwestern Tarim basin in the Early Cretaceous. Early Cretaceous intensive thrusting, magmatic emplacement and volcanic eruptions occurred in the central and northern Lhasa Block, while strikeslip formed along the Hoh-Xil and South Kunlun Faults in the northern Tibetan region. Early Cretaceous tectonics together with magmatic K2O geochemistry indicate an Early Cretaceous southward subduction of the Mid-Tethys Oceanic Plate along the Bangoin-Nujiang Suture which was thrust 87 km southward during the Late Cretaceous-Early Cenozoic. No intensive thrust and magmatic emplacement occurred in the Early Cretaceous in the Himalayan and southern Lhasa Blocks, indicating that the spreading Neo-Tethys Oceanic Plate had not been subducted in the Early Cretaceous. To the north, terrestrial basins of red-beds formed in the Hoh-Xil, Kunlun, Qilian and the northeastern Tarim blocks in Early Cretaceous, and the Qiangtang Marginal Sea disappeared after the Qiangtang Block uplifted in the late Early Cretaceous. | WU Zhenhan ZHAO Zhen Patrick J. BAROSH YE Peisheng | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 7 |
| 16 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 17 | 3D printing of silk fibroin-based hybrid scaffold treated with platelet rich plasma for bone tissue engineering显示文摘3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering.In this study,we developed a composite bioink consisting of silk fibroin(SF),gelatin(GEL),hyaluronic acid(HA),and tricalcium phosphate(TCP)and 3D bioprinted the silk fibroin-based hybrid scaffolds.The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma(PRP)to generate PRP coated scaffolds.Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells(HADMSC).In addition,the treatment of PRP did not significantly affect alkaline phosphatase(ALP)activity and expression,but significantly upregulated the gene expression levels of late osteogenic markers.This study demonstrated that the 3D printing of silk fibroin-based hybrid scaffolds,in combination with PRP post-treatment,might be a more efficient strategy to promote osteogenic differentiation of adult stem cells and has significant potential to be used for bone tissue engineering. | Liang Wei Shaohua Wu Mitchell Kuss Xiping Jiang Runjun Sun Reid Patrick Xiaohong Qin Duan Bin | 2019 | Bioactive Materials2019，4，1： | 6 |
| 18 | Growth performance of nursery and grower-finisher pigs fed diets supplemented with benzoic acid显示文摘Two experiments were conducted to investigate the efficacy of benzoic acid on the growth performance of nursery and grower-finisher pigs. A randomized complete block design was used in both experiments with the initial body weight as the blocking factor. There were 3 treatments corresponding to 3 dietary levels of benzoic acid: 0, 0.3%, and 0.5%. In experiment 1, a total of 144 PIC L1050 barrows(initial body weight 7.1 ± 0.6 kg) were used with each treatment replicated 8 times. In experiment 2, a total of 288 PIC L1050 barrows(initial body weight 36.1 ± 3.6 kg) were used with each treatment replicated 16 times.There were 6 barrows in each replicate pen for both experiments. Experiments 1 and 2 lasted 28 and 70 days, respectively. In experiment 1, average daily gain(ADG) of all growth phases increased linearly(P < 0.05) with increasing supplementation of benzoic acid, which led to a linear improvement in average body weight on d 28(P < 0.05). There was also an improvement in feed conversion ratio(FCR) of d 0 to 14(linear effect: P < 0.05) and in average daily feed intake(ADFI) of d 14 to 28 and d 0 to 28(linear effect:P < 0.01). In experiment 2, ADG during d 0 to 35 and d 35 to 70 and average body weight on d 35 improved linearly(P < 0.05) with increasing supplementation of benzoic acid. Average daily gain of d 0 to70 and average body weight on d 70 increased significantly in a both linear and quadratic manner. There was a linear improvement in FCR in all growth phases(P < 0.05). In conclusion, the dietary inclusion of benzoic acid at the supplementation levels of 0.3% and 0.5% significantly improved the growth performance of nursery and grower-finisher pigs in the current study; the nursery pigs responded to the dietary supplementation of benzoic acid up to 0.5% linearly while the grower-finisher pigs achieved the optimal ADG at the calculated supplementation level of 0.36%. | Hengxiao Zhai Wen Ren Shikui Wang Jinlong Wu Patrick Guggenbuhl Anna-Maria Kluenter | 2017 | Animal Nutrition2017，，3： | 4 |
| 19 | 横向非均匀地球负荷问题的CLFE有限元算法的有效性显示文摘本文设计了三个数值算例分别模拟径向分层黏弹地球对二阶球谐负荷、均厚圆盘负荷和全球末次冰期真实冰负荷的响应.利用耦合位扰动Laplace方程的三维有限元法(CLFE),计算出地球表面的位移、大地水准面的变化、冰后海平面变化和这些量的现今变化速率,并将其结果与传统谱方法的结果进行对比.结果表明,两种方法的结果总体上表现出良好的一致性,因此,CLFE方法被证实是正确的、有效的、能被用于研究地幔横向非均匀性的影响.值得注意的是,新的方法完全没有横向非均匀小扰动假设的限制. | 汪汉胜 Wu Patrick Schotman Hugo 王志勇 | 2006 | 地球物理学报2006，49，6： | 4 |
| 20 | 不同模型的地表质量异常一阶项、二阶项估计显示文摘为了合理补充重力场恢复与气候试验卫星(Gravity Recovery and Climate Experiment,GRACE)时变重力场的一阶斯托克斯系数(C10、C11、S11)和替换二阶斯托克斯系数(C20),介绍了相关GRACE-OBP算法及其改进的算法,比较了相应的Chamber Model和4个Sun Model的一阶系数及其计算的地表质量异常,同时比较了基于卫星激光测距观测的Cheng Model与4个Sun Model的C20及其地表质量异常。结果表明,GRACE-OBP算法的一阶系数、卫星激光测距观测的C20及其地表质量异常与改进的GRACE-OBP算法在趋势项上有很大差异,但周年项差异相对较小。利用不同截断阶数和不同机构的GRACE时变重力场模型,对其趋势项和周年项都有一定影响,且对趋势项影响更大。因此,在计算陆地水储量变化时,建议使用改进的GRACE-OBP算法的估计结果,使用较理想的、截断阶数较高的GRACE时变重力模型。 | 汪汉胜 相龙伟 Wu Patrick Steffen Holger 贾路路 | 2018 | 武汉大学学报(信息科学版)2018，43，12： | 3 |
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