|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | A Novel Semiconductor CIGS Photovoltaic Material and Thin-Film ED Technology显示文摘In order to achieve low cost high efficiency thin film solar cells,a novel Semiconductor Photovoltaic (PV) active material CuIn 1-x Ga x Se 2 (CIGS) and thin film Electro Deposition (ED) technology is explored.Firstly,the PV materials and technologies is investigated,then the detailed experimental processes of CIGS/Mo/glass structure by using the novel ED technology and the results are reported.These results shows that high quality CIGS polycrystalline thin films can be obtained by the ED method,in which the polycrystalline CIGS is definitely identified by the (112),(204,220) characteristic peaks of the tetragonal structure,the continuous CIGS thin film layers with particle average size of about 2μm of length and around 1 6μm of thickness.The thickness and solar grade quality of CIGS thin films can be produced with good repeatability.Discussion and analysis on the ED technique,CIGS energy band and sodium (Na) impurity properties,were also performed.The alloy CIGS exhibits not only increasing band gap with increasing x ,but also a change in material properties that is relevant to the device operation.The beneficial impurity Na originating from the low cost soda lime glass substrate becomes one prerequisite for high quality CIGS films.These novel material and technology are very useful for low cost high efficiency thin film solar cells and other devices. | ZHENG Guang fu 1,YANG Hong xing 1,MAN Cheuk ho 1,WONG Wing lok 2, AN Da wei 1 and John BURNETT 1(1 Centre for Development of Solar Energy Technology,Department of Building Services Engineering, The Hong Kong Polytechnic University,Hong Kong,C | 2001 | Journal of Semiconductors2001，22，11： | 10 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Environmental factors affecting growth of grasses,herbs and woody plants on a sanitary landfill显示文摘Environmentalfactorsaffectinggrowthofgrasses,herbsandwoodyplantsonasanitarylandfillLanChongyu;WongMinghung(DepartmentofBiolog... | Lan Chongyu Wong Minghung(Department of Biology and Center for Waste Recycling &Environmental Biotechnology, Hong Kong BaptistCollege, 224 Waterloo Road, Kowloon, Hong Kong) | 1994 | Journal of Environmental Sciences1994，6，4： | 5 |
| 5 | Uptake,Depuration and Subcellular Distribution of Cadmium in Various Tissues of Perna viridis显示文摘Green-lipped mussels (Perna viridis) were collected from a local mariculture site and placed in pre-cleaned sea water tanks containing 0, 0.2, 0.5 and 1.3 μg/ml CdCl2. The level of Cd in the gill, viscera and gonad was measured. The concentration of Cd in the 3 tissues increased linearly over 4 days’ of exposure. The rate of uptake depends on the concentration of Cd in the water. In the 3 tissues studied, the maximum rate of uptake (Vmax) was highest in the gill (500μg/g dry weight/day), followed by viscera (100μg/g dry weight/day) and gonad (56.8 μg/g dry weight/day). The majority of the Cd taken up was bound to a fraction of the heat-stable proteins similar to metallothioneins. The rate of Cd depuration from the tissues was poor. There was no change in Cd concentration over 8 days’ depuration in clean | M. S. YANG S. T. CHIU AND M. H. WONG(Department of Biology and Center for Waste Recycling and Environmental Biotechnology, Hong Kong Baptist University, Kowloon Tong, Hong Kong) | 1995 | Biomedical and Environmental Sciences1995，8，2： | 4 |
| 6 | Metal removal studied by a laboratory scale immobilized microalgal reactor显示文摘1IntroductionIndustrialwastewaters,particularlythosedischargedfrommanufacturingofprintedcircuitboard(PCB)andelectroplatingcon... | Arthur Lau, Yuk Shan Wong Research Center/Biology Department, Hong Kong University of Science and Technology, Clearwater Road, Kowloon, H.K. Zhang Tong ** CEDRC, Beijing 100028, China Nora F.Y.Tam Department of Biology and Chemistry, City University of Hong Kong, Kowloon, H.K. | 1998 | Journal of Environmental Sciences1998，10，4： | 3 |
| 7 | INTRODUCTION OF NEW ANTICORROSIVE DESIGN FOR REACTORS EXPOSED TO HIGH TEMPERATURE AND HIGH PRESSURE HYDROGEN显示文摘This paper integrates the characteristic of structure design and manufacture and maintenance for Chinese flat steel band wound pressure vessel(UCWPV) with the problems existing in current in service high temperature and pressure vessel exposed to hydrogen. In view of economy and safety it is suggested that it be practicable for UCWPV to act as reactors for platreating, hydrogenating, and catforming. UCWPV has not only potential advantages, but also removes shortages present in in-service reactors for hydrogen. | J.L. Li 1,2) , K.F. Wong 3) and G.H. Zhu 3) 1) Fushun Petroleum Institute,Fushun 113001,China 2) State Key Laboratory for Corrosion and Protection of Metal,Institute of Corrosion and Protection of Metals, The Chinese Academy of Sciences,S | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 3 |
| 8 | SIGMAPLUG—A NEW TEMPERATURE INDICATOR FOR REMAINING LIFE ASSESSMENT OF HIGH TEMPERATURE COMPONENTS显示文摘1.IntroductionItisgeneralyacceptedthattheeficiencyandreliabilityofpowerplantsareofparamountimportanceinsupportingthegrowthoft... | J.K.L. Lai, C.H. Shek and K.W. Wong Department of Physics and Materials Science, City University of Hong Kong, 27887808, China | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，1： | 2 |
| 9 | On comparison of jump point detection for an exchange rate series显示文摘The main purpose of this paper is to investigate the detection of jump points of a discontinuous function in the presence of a noise by the wavelet approach. A computing algorithm of our method is proposed and then applied to the daily exchange rate of US Dollar against Deutsche Mark. All the points detected by our method reflect very strong economic and political impacts. Other statistical methods to detect jump points have also been applied to the same exchange rate data. Our proposed method has produced more convincing empirical results than others. | IP Wai-Cheung, WONG Heung, XIE Zhongjie & LUAN YihuiDepartment of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, China Department of Probability and Statistics, Peking University, Beijing 100871, China | 2004 | Science China Mathematics2004，47，1： | 2 |
| 10 | American College of Gastroenterology guideline on the management of Helicobacter pylori infection 显示文摘 | Chey WD Wong BC Practice Parameters Committee of the American College of Gastroenterology | 2007 | Am J Gastroenterol2007，102，8： | 1 |
| 11 | Retrospective review of clinical presentations,microbiology,and outcomes of patients with psoas abscess显示文摘 | Wong OF Ho PL Lam SK | 2013 | Hong Kong Med J2013，124，177： | 1 |
| 12 | A meta-analysis显示文摘 | Wong DK Cheung AM O'Rourke K Naylor CD Detsky AS Heathoote J:Effect of alpha-interferon treatment I patiens with hepatitis B e antigen-positive chronic hepatitis B | 1993 | Aun Intern Med1993，119，4： | 1 |
| 13 | A Novel Parsimonious Neurofuzzy Model Applied to Railway Carriage System Identification and Fault Diagnosis显示文摘ANovelParsimoniousNeurofuzzyModelAppliedtoRailwayCariageSystemIdentificationandFaultDiagnosisS.C.Zhou,O.L.Shuai+,T.T.Wong?.. | S. C. Zhou *, O. L. Shuai +, T. T. Wong *, T. P. Leung * ** This Project is Supported Partly by National Natural Science Foundation of China(69572014) * Dept.ME,Hong Kong Polytechnic University,Hong Kong + Dept.EE,South China University of T | 1997 | International Journal of Plant Engineering and Management1997，2，4： | 1 |
| 14 | American College of Gastroenterology guideline on the management of Helicobacter pylori infection显示文摘 | Chey WD Wong BC Practice Parameters Committee of the American College of Gastroenterology | 2007 | Am J Gastroenterol2007，102，8： | 1 |
| 15 | Hemolytic anemia after zo- piclone overdose 显示文摘 | Fung HT Lai CH Wong OF | 2009 | Clin Toxicol ( Phila)2009，47，9： | 1 |
| 16 | Two cases of methemoglo- binemia following zopiclone ingestion显示文摘 | Fung HT Lai CH Wong OF | 2008 | Clin Toxicol ( Phi- la)2008，46，2： | 1 |
| 17 | 电子投票系统的安全问题(英文)显示文摘已有几种电子投票系统被提出以取代现有利用电话、信函等工作的投票系统。然而,许多电子投票系统或是完全或是部分地忽略了电子投票的安全问题。这已经阻碍了对电子投票的普遍接受和信任。讨论并指出了产生于电子投票中的不同安全问题。文章的工作是一次理解电子投票系统风险的尝试,而这种尝试对定义防止欺骗与滥用的安全措施是极为重要的。最后描述了一种原型系统。 | Cheng Chunhung Cheng Waiman Wong Kamfai(The Chinese University of Hong Kong,Shatin,NT,Hong Kong,PRC) | 1999 | 计算机工程1999，25，S1： | 1 |
| 18 | Performance of multi- detector computed tomographic angiography in determining surgical resectability of pancreatic head adenocarcinoma 显示文摘 | Kaneko OF Lee DM Wong J | 2010 | J Comput Assist Tomogr2010，34，5： | 1 |
| 19 | The level of accuracy FEO2, FECO2 and Vr between the Cosmed k4b2 portable, respiratory gas analysis system and a metabolic cart显示文摘 | PINNINGTON H C WONG P and agreement in measures of TAY J | 2001 | JSci Med Sport2001，4，3： | 1 |
| 20 | Chinese consensus statement on the evaluation and inter- vention of collateral circulation for ischemic stroke 显示文摘 | Liu LP Xu AD Wong LK Expert consensus group of the evaluation & intervention of collateral circulation for ischemic stroke | 2014 | CNS Neurosci Ther2014，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员