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| 1 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘 | Seol D J Won Y M Oh K H | 2000 | ISIJ International2000，40，4： | 1 |
| 4 | High Temperature Deformation Behavior of Carbon Steel in the Austenite and δ-Ferrite Regions显示文摘 | Seol D J Won Y M Yeo T J | 1999 | ISIJ International1999，39，1： | 1 |
| 5 | Effects of beryllium on human serum immunoglobulin and lymphocyte subpopulation 显示文摘 | Kim KW Kim D Won YL | 2013 | Toxicol Res2013，29，2： | 1 |
| 6 | Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow 显示文摘 | Won D Zhu SN Chen M | 2007 | Am J Pathol2007，171，5： | 1 |
| 7 | 显示文摘 | Chuu D S Won W L Pei J H | 1994 | Phys Rev B1994，49，14： | 1 |
| 8 | Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘 | Seol D J Won Y M Oh K H | 2000 | ISIJ International2000，40，4： | 1 |
| 9 | Cryoglobulinemic vasculitis and monoclonal gammopathy in end - stage renal disease 显示文摘 | Won D Park C J Chang JW | 2011 | Korean J Hematol2011，46，4： | 1 |
| 10 | GEM-2:A new multifrequency electro- magnetic sensor显示文摘 | Won I J Keiswetter D A Fields G RA and Sutton L C | 1996 | Journal of Environmental and Engineering Geophysics1996，1，2： | 1 |
| 11 | Synthesis of acrylic acidbased superabsorbent interpenet rated with sodium sulfate using inverse-emulsionpolymerization显示文摘 | Won L D Geun S K Jong Y K | 2002 | European Polymer Journal2002，38，3： | 1 |
| 12 | Changes in S-allylcysteine contents and physicochemical properties of black garlicduring heat treatment显示文摘 | BAE S E CHO S Y WON Y D | 2014 | LWT-Food Science and Technology2014，55，： | 1 |
| 13 | ID-based group signature显示文摘 | Park S Kim S Won D | 1997 | Electronics Letters1997，33，19： | 1 |
| 14 | Morphological shared-weight networks with applications to automatic target recognition显示文摘 | WON Y G GADER P D COFFIELD P C | 1997 | IEEE Trans Neural Networks1997，8，5： | 1 |
| 15 | Nanotechnology, nanotoxicology, and neuroscience 显示文摘 | WON HYUK SUH KENNETH S SUSLICK GALEN D STUCKY | 2009 | Pro- gress in Neurobiology2009，87，3： | 1 |
| 16 | A step,stride and heading determination for the pedestrian navigation system显示文摘 | J Won Kim H J Jang D Hwang C Park | | 0，，1： | 1 |
| 17 | An adequate level of training for technical competence in screening and diagnostic colonoscopy: a prospective multicenter evaluation of the learning curve显示文摘 | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Young Hwangbo Won Ho Kim Dong Hun Park Sang Kil Lee Cheol Hee Park Il-Hyun Baek Dong Il Park Seun-Ja Park Jeong-Seon Ji Byung-Ik Jang Yoon-Tae Jeen Jeong Eun Shin Jeong-Sik Byeon Chang-Soo Eun D | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 18 | Prenatal stress alters seizure thresholds and the development of kindled seizures in infant and adult rats 显示文摘 | Edwards HE Dortok D Tam J Won D Burnham WM | 2002 | Horm Behavior2002，42，4： | 1 |
| 19 | An experimental study of the performance of a dual loop refrigerator/freezer system显示文摘 | Won S Jung D Radermaeher R | 1994 | Int J Refrig1994，17，6： | 1 |
| 20 | Novel biodegradable copolymers containing pendent amine functional groups based on aspartic acid and poly Cethylcnc glycol) 显示文摘 | Won C v Chu C C Lee J D | 1998 | Polymer1998，25，39： | 1 |
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