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| 1 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | The importance of lytic and nonlytic immune responses in viral infections显示文摘 | Wodarz D Christensen J P Thomsen A R | 2002 | Trends Immunol2002，23，： | 1 |
| 4 | Establishing cell polarity in development 显示文摘 | Wodarz A | 2002 | Nat Cell Biol2002，4，2： | 1 |
| 5 | Asymmetric cell division during neurogenesis in Drosophila and vertebrates显示文摘 | Wodarz A Huttner WB | 2003 | Mech Dev2003，120，11： | 1 |
| 6 | Mechanisams of Wnt signaling in development显示文摘 | Wodarz A Nusse R | 1998 | Annu Rev Cell Dev Biol1998，14，： | 1 |
| 7 | Mechanisms of Wnt signaling in development显示文摘 | Wodarz A | 1998 | Ann Rev Cell Dev Bio11998，，14： | 1 |
| 8 | Virus Dynamics: the Effect of Target Cell Limitation and Immune Response on Virus Evolution 显示文摘 | Roland R Regoes Dominik Wodarz Martin A Nowak | 1998 | J Theor Biol1998，191，： | 1 |
| 9 | Asymmetric cell division during neurogenesis of Drosophila and vertebrates 显示文摘 | Wodarz A Huttner WB | 2003 | Mech Dev2003，120，11： | 1 |
| 10 | Viruses as antitumor weapons : defining conditions for tumor re- mission显示文摘 | Wodarz D | 2001 | Cancer Res2001，61，8： | 1 |
| 11 | Mechanisms of Wnt signaling in development 显示文摘 | Wodarz A Nusse R | 1998 | Annu Rev Cell Dev Biol1998，14，： | 1 |
| 12 | Virus dynamics z the effect of target cell limitation and immune responses on virus evolution显示文摘 | Regoes R R Wodarz D Nowak M A | 2010 | J Theor Biol2010，191，： | 1 |
| 13 | The dynamics of HTL V-I and the CTL response显示文摘 | Wodarz D Nowak M A Bangham C R M | 1999 | Immunology Today1999，20，5： | 1 |
| 14 | Mechanisms of Wnt signaling in develop- ment显示文摘 | Wodarz A Nusse R | 1998 | Annu Rev Cell Dev Biol1998，14，： | 1 |
| 15 | Establishing cell polarity in development显示文摘 | Wodarz A | 2002 | Nat Cell Biol2002，4，2： | 1 |
| 16 | Cell polarity in development and cancer显示文摘 | Wodarz A N?thke I | 2007 | Nat Cell Biol2007，9，9： | 1 |
| 17 | Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts显示文摘 | Wodarz A | 2005 | Curr Opin Cell Biol2005，17，5： | 1 |
| 18 | Dopamine D2 (DAD2) and dopamine D3 (DAD3) receptor gene polymorphisms and treatment outcome in alcohol dependence显示文摘 | Wiesbeck GA Weijers HG Wodarz N Herrmann MJ Johann M Keller HK Michel TM Bning J | | 0，，07： | 1 |
| 19 | Mechanisms of Wnt signaling in development显示文摘 | Wodarz A R Nusse | 1998 | Annu Rev Cell Dev Biol1998，14，1： | 1 |
| 20 | Defining CTL-induced pathol- ogy: Implications for HIV显示文摘 | WODARZ D KRAKAUER D C | 2000 | Virology2000，274，： | 1 |
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