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| 1 | 【特刊综述】男性睡眠障碍和睾酮的关系显示文摘血浆睾酮水平呈现昼夜节律变化,睡眠时达高峰,午后降至最低,伴随一个叠加的具有反映黄体生成素(LH)脉冲式分泌基础节律的每90分钟一次脉冲的超昼夜节律。能促进睾酮增加的是睡眠而不是昼夜节律,依赖并需要至少三个小时正常结构的睡眠。多种睡眠障碍包括睡眠质量、持续时间异常、昼夜节律紊乱、睡眠呼吸障碍可能会导致睾酮水平下降。睡眠限制或昼夜节律紊乱不依赖于性激素结合球蛋白而直接影响睾酮的证据或共存疾病的存在是模棱两可的,总的看起来证据不足。在对年龄和肥胖进行调整后,阻塞性睡眠呼吸暂停(OSA)看起来似乎对睾酮没有直接影响。尽管如此,也许存在一种潜在的由OSA对肥胖的影响所介导的的间接因果过程。大多数研究中采用持续正压通气(CPAP)治疗中到重度OSA并没有真正提高睾酮水平。相反,体重减轻却的确提高了睾酮水平,并且与体重下降情况成线性比例。睾酮治疗除了具有非常短暂的毒副作用,对OSA并没有不利影响。睡眠质量对睾酮影响的研究数据可能取决睾酮给药是作为替代、超治疗剂量还是在滥用的范围。实验数据显示睾酮可以调节睡眠限制的主观症状的个体易患性。睾酮低下可能会影响整个睡眠质量,给予替代剂量可以得到改善。大剂量外源性雄激素和促进合成或促进雄激素产生的甾体激素滥用与睡眠持续时间和结构异常有关。 | Gary Wittert | 2014 | Asian Journal of Andrology2014，16，2： | 15 |
| 2 | Outcomes of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding显示文摘AIM:To evaluate weight loss and surgical outcomes of Roux-en-Y gastric bypass(RYGB)and laparoscopic adjustable gastric band(LAGB).METHODS:Data relating to changes in body mass index(BMI)and procedural complications after RYGB(1995-2009;n=609;116M:493F;42.4±0.4 years)or LAGB(2004-2009;n=686;131M:555F;37.2±0.4years)were extracted from prospective databases.RESULTS:Pre-operative BMI was higher in RYGB than LAGB patients(46.8±7.1 kg/m2vs 40.4±4.2 kg/m2,P<001);more patients with BMI<35 kg/m2underwent LAGB than RYGB(17.1%vs 4.1%,P<0.0001).BMI decrease was greater after RYGB.There were direct relationships between weight loss and pre-operative BMI(P<0.001).Although there was no difference in weight loss between genders during the first 3-year post-surgery,male LAGB patients had greater BMI reduction than females(-8.2±4.3 kg/m2vs-3.9±1.9kg/m2,P=0.02).Peri-operative complications occurred more frequently following RYGB than LAGB(8.0%vs0.5%,P<0.001);majority related to wound infection.LAGB had more long-term complications requiring corrective procedures than RYGB(8.9%vs 2.1%,P<0.001).Conversion to RYGB resulted in greater BMI reduction(-9.5±3.8 kg/m2)compared to removal and replacement of the band(-6.0±3.0 kg/m2).Twelve months post-surgery,fasting glucose,total cholesterol and low density lipoprotein levels were significantly lower with the magnitude of reduction greater in RYGB patients.CONCLUSION:RYGB produces substantially greater weight loss than LAGB.Whilst peri-operative complications are greater after RYGB,long-term complication rate is higher following LAGB. | Nam Q Nguyen Philip Game Justin Bessell Tamara L Debreceni Melissa Neo Carly M Burgstad Pennie Taylor Gary A Wittert | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 3 | Endogenous testosterone and mortality risk显示文摘在人,肥胖和新陈代谢的复杂并发症与更低的浆液睾丸激素被联系(T) 和 dihydrotestosterone 和增加的风险,和死亡从(DHT ) ,除了心血管的疾病(CVD ) 的多重长期的疾病。在这些因素之间的原因的相互关系仍然是争论的一件事。在有 hypogonadotropic 性腺机能减退的未经治疗的先天、终生的形式的人,看起来不是增加的风险。有 Klinefelters 症候群的人有癌症,以及 CVD 的各种各样的类型的增加的风险,尽管有 T,它坚持治疗。当 hypothalamic-pituitary-gonadal 轴的病理不在时,在在使人变老的浆液 T 的谦虚减小的效果是不清楚的。低浆液 T 集中的流行在有癌症,肾的疾病,和呼吸疾病的人高并且是可能的是全身的疾病,不是性腺机能减退的严厉的指示物。一些基于人口的研究发现了低浆液 T 与归因于癌症,肾的疾病,和呼吸疾病的死亡的更高的风险被联系,当其它没有时。尽管纵的研究的元分析显示出在低浆液 T 和所有原因死亡之间的一个协会,在研究之间的显著异质限制了一个坚挺的结论。因此,当在以后特别地发生在生活的 T 的减少可以与人的所有原因和死亡的特定的类型的增加被联系时,如果有的话,微分效果作为与健康和生活方式因素相比 T 和另外的性别类固醇是未知的在当前的时间。 | Emily J Meye Gary Wittert | 2018 | Asian Journal of Andrology2018，20，2： | 2 |
| 4 | Tissue distribution of opioid receptor gene expression in the rat显示文摘 | Wittert G Hope D Pyle D | 1996 | Biochem Biophys Res Commun1996，218，： | 1 |
| 5 | Tissue distribution of opioid recep- tor gene expression in the rat 显示文摘 | Wittert G Hope P Pyle D | 1996 | Biochem Biophys Res Conl: mun1996，218，3： | 1 |
| 6 | Complications in sub- fascial endoscopic perforating vein surgery: a report of two eases显示文摘 | Geselschap JH van Gent WB Witterts CH | 2001 | J Vase Surg2001，33，5： | 1 |
| 7 | AMPK and ACC phosphorylation: Effect of leptin, muscle fibre type and obesity显示文摘 | A. Janovská G. Hatzinikolas V. Staikopoulos J. McInerney M. Mano G.A. Wittert | 2008 | Molecular and Cellular Endocrinology2008，，1： | 1 |
| 8 | Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation:a randomized clinical trial显示文摘 | Abed HS Wittert GA Leong DP | 2013 | JAMA2013，310，19： | 1 |
| 9 | Management of obesity in patients type 2 diabetes mellitus 显示文摘 | Gagliardi L Wittert G | 2007 | Curr Diabetes Rev2007，3，2： | 1 |
| 10 | Adaptation of the Hypothalamopituitary Adrenal Axis to Chronic Exercise Stress in Humans显示文摘 | WITTERT G A LIVESEY J H ESPINER E A | 1996 | Med Sci Sports Exe1996，28，8： | 1 |
| 11 | Tissue distribution of opioid recep- tor gene expression in the rat显示文摘 | Wittert G Hope P Pyle D | 1996 | Biochem Biophys Res Corn- mum1996，218，3： | 1 |
| 12 | Tissue distribution of opioid receptor gene expression in the rat 显示文摘 | WITTERT G HOPE P PYLE D | 1996 | Biochem Biophys Res Comm1996，218，3： | 1 |
| 13 | Monosodium glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years:findings from Jiang Su Nutrition Study of Chinese adults显示文摘 | Shi Z Luscombe -Marsh ND Wittert GA | 2010 | The British Journal of nutrition2010，8，： | 1 |
| 14 | Tissue distribution of opioid receptor gene expression in the rat显示文摘 | WITTERT G HOPE P PYLE D | 1996 | Biochem Biophys Res Commun1996，218，3： | 1 |
| 15 | Tissue distribution of opi- oid receptor gene expression in the rat显示文摘 | Wittert G Hope P Pyle D | 1996 | Biophys Res Commun1996，218，： | 1 |
| 16 | Management of obesity in patients with type 2 diabetes mellitus 显示文摘 | Gagliardi L Wittert G | 2007 | Curr Diabetes Rev2007，3，2： | 1 |
| 17 | Tissue distribution of opioid receptor gene expression in the rat显示文摘 | WITTERT G HOPE P PYLE D | 1996 | Biochem Biophys Res Commum1996，218，3： | 1 |
| 18 | Ghrelin and Measures of Satiety Are Altered in Polycystic Ovary Syndrome But Not Differentially Affected by Diet Composition显示文摘 | L J. Moran M Noakes P M. Clifton G A. Wittert L Tomlinson C Galletly N D. Luscombe R J. Norman | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，7： | 1 |
| 19 | Tissue distribution of opioid receptor gene expression in the rat 显示文摘 | Wittert G Hope P Pyle D | 1996 | Biochem Biophys Res Commun1996，218，3： | 1 |
| 20 | Tissue distribution of opioid receptor gene expression in the rat 显示文摘 | Wittert G Hope P Pyle D | 1996 | Biochem Biophys Res Commum1996，218，3： | 1 |
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