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| 1 | Synergistic activity of lawsone methyl ether in combination with some antibiotics and artocarpin against methicillin-resistant Staphylococcus aureus, Candida albicans, and Trychophyton rubrum显示文摘Objective: One appealing strategy to overcome and prevent resistant problem is the use of combined two or more antibacterial substances. Lawsone methyl ether(LME) is the naphthoquinone found in the leaves of Impatiens balsamina. The objective of this study is to determine the interaction of LME with some antibiotics(ampicillin, tetracycline, norfloxacin, and clotrimazole) and a natural compound, artocarpin against methicillin-resistant Staphylococcus aureus(MRSA), Candida albicans, and Trychophyton rubrum.Methods: A broth microdilution method was used to determine the minimum inhibition concentration(MIC). Synergistic effects were evaluated at their own MIC using the checkerboard method and time-kill assay.Results: LME showed moderate antibacterial activity against MRSA with MIC value of 15.6 μg/mL, and exhibited strong antifungal activities against T. rubrum and C. albicans with MIC values of 7.8 and 3.9 μg/m L,respectively. The interaction of LME with the natural compound artocarpin against MRSA produced a synergy with fractional inhibitory concentration index(FICI) value of 0.31, while the combination of LME and clotrimazole exhibited synergy against C. albicans and T. rubrum with FICI values of 0.38 and 0.24, respectively. The time-kill assays confirmed that the compounds in combination enhanced their antimicrobial activities against the resistant microorganisms with different degrees.Conclusion: LME in combination with clotrimazole exhibited synergy effect against C. albicans and T.rubrum. In combination with artocarpin, it showed synergy effect against MRSA. | Pharkphoom Panichayupakaranant Abdi Wira Septama Akarawat Sinviratpong | 2019 | Chinese Herbal Medicines2019，11，3： | 11 |
| 2 | Antigen-presenting cells in the female reproductive tract: influence of the estrous cycle on antigen presentation by uterine epithelial and stromal cells显示文摘 | Wira C R Rossoll R M | 1995 | Endocrinology1995，136，10： | 1 |
| 3 | Sex Hormone Regulation of Innate Immunity in the Female Reproductive Tract:The Role of Epithelial Cells in Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens显示文摘 | Wira CR Fahey JV Ghosh M | | 0，，06： | 1 |
| 4 | Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens 显示文摘 | Wira CR Fabey JV Ghosh M | 2010 | Am J Reprod Immuno12010，63，6： | 1 |
| 5 | A unified artificial neural network architecture for active power 显示文摘 | ABDESLAM D O WIRA P MERCKLE J | 2007 | Industrial Electronics2007，54，1： | 1 |
| 6 | Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections显示文摘 | Wira CR Patel MV Ghosh M | 2011 | AmJ Reprod Immunol2011，65，3： | 1 |
| 7 | Effect of oestradiol on mouse uterine epithelial cell tumour necrosis factor-αrelease is mediated through uterine stromal cells显示文摘 | GRANT T K S WIRA C R KATHERINE S G T et a1 | 2005 | Immunology2005，115，： | 1 |
| 8 | Epidemiology and outcomes of fever burden among patients with acute ischemic stroke显示文摘 | Phipps MS Desai RA Wira C | 2011 | Stroke2011，42，12： | 1 |
| 9 | The role of sex hormones in immune protection of the female reproduc- tive tract显示文摘 | Wira CR Rodriguez-Garcia M Patel MV | 2015 | Nat Rev Immunol2015，15，4： | 1 |
| 10 | Antigen presentation by vaginal ceils: role of TGF-β1 as a mediator of es tradiol inhibition of antigen presentation显示文摘 | WIRA C R ROCHE M A ROSSOLL R M | 2002 | Endocrinology2002，143，8： | 1 |
| 11 | Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone 显示文摘 | Sentman CL Meadows SK Wira CR | 2004 | J Immunol2004，173，11： | 1 |
| 12 | Sex Hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens 显示文摘 | Wira CR Fahey JV Ghosh M | 2010 | Am J Re-prod Immunol2010，63，6： | 1 |
| 13 | Endogenous transforming growth factor-beta inhibits toll-like receptor mediated activation of human uterine natural killer cells 显示文摘 | Eriksson M Meadows SK Wira CR | 2006 | Am J Reprod Immunol2006，56，56： | 1 |
| 14 | Regulation of mucosal immunity in the female reproductive tract:the role of sex hormones in immune protection against sexually transmitted pathogens 显示文摘 | Wira CR Fahey JV Rodriguez-Garcia M | 2014 | Am J Reprod Immuno12014，72，2： | 1 |
| 15 | A unifiedartificial neural network architecture for active power filters显示文摘 | ABDESLAM D O’ WIRA P MERCKLE J | 2007 | IEEE Trans on Industrial Electronics2007，54，1： | 1 |
| 16 | Sex hormone regulation ofanti-bacterial activity in rat uterine secretions and apical releaseof anti-bacterial factor(s)by uterine epithelial cells in culture显示文摘 | Fahey JV Rosoll RM and Wira CR | 2005 | Steroid Biochem Mol Biol2005，93，1： | 1 |
| 17 | Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone显示文摘 | Sentman C L Meadows S K Wira C R | 2004 | J Immunol2004，173，11： | 1 |
| 18 | A Unified Artificial Neural Network Architecture for Active Power Filters显示文摘 | Abdeslam D O Wira P Merckle J | 2007 | Industrial Electronics2007，54，1： | 1 |
| 19 | The innate immune system: gatekeeper to the female reproductive tract 显示文摘 | Wira C R Fahey J V | 2004 | Immunology2004，111，： | 1 |
| 20 | Innate and adaptive immunity in female genital tract: cellular responses and interactions显示文摘 | Wira CR Fahey JV Sentman CL | 2005 | Immunol Rev2005，206，： | 1 |
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