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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Therapeutic drug monitoring of antiepileptics by capillary electrophoresis ( Characterization of assays via analysis of quality control sera containing 14 analytes) 显示文摘 | Thormann W Theurillat R Wind M | 2001 | J Chromatogr A2001，924，： | 1 |
| 3 | High yield secretion of recombinant gelatins by Pichia Pastoris显示文摘 | Werten M W Vande Bosch T J Wind R D | 1999 | Yeast1999，15，11： | 1 |
| 4 | An isolate of Exserohilure turcicum virulent on maize inbreds with resistance gene HtN 显示文摘 | WINDES J M PEDERSON W L | 1991 | Plant Disease1991，75，7： | 1 |
| 5 | Current trends in anterior cruciate ligament reconstruction 显示文摘 | DuquinT R Wind W M Fineberg M S | 2009 | J Knee Surg2009，2，1： | 1 |
| 6 | Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps显示文摘 | Murphy W J Larkin D M Wind AE D | 2005 | Science2005，309，5734： | 1 |
| 7 | An isolate of Exsero-hilum turcicum virulent on maize inbreds with resistancegene HtN显示文摘 | WINDES J M PEDERSON W L | 1991 | Plant Disease1991，75，： | 1 |
| 8 | Highyield zecretion of recombinant gelatins by Pichia pastoris显示文摘 | Werten M W T T J Van den Bosch Wind R D | 1999 | Yeast1999，15，11： | 1 |
| 9 | Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a ran- domized clinical trial (LAFA- study)显示文摘 | VLUG M S WIND J HOLLMANN M W | 2011 | Ann Surg2011，254，6： | 1 |
| 10 | Dynam- ics of mammalian chromosome evolution inferred from multispe- cies comparative maps显示文摘 | Murphy W J Larkin D M Everts-van der Wind A | 2005 | Science2005，309，： | 1 |
| 11 | Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical trial (LAFA-study) 显示文摘 | Vlug M S Wind J Hollmann M W | 2011 | Ann Surg2011，254，6： | 1 |
| 12 | An isolate of Exserohilum turcicum virulent on maize inbreds with resistance gene HtN显示文摘 | WINDES J M PEDERSON W L | 1991 | Plant Dis1991，75，7： | 1 |
| 13 | Dynamics of mammalian chromosome evolution inferred from muhispecies comparative maps 显示文摘 | Murphy W J Larkin D M Evens-van der Wind A | 2005 | Science2005，309，5734： | 1 |
| 14 | The chicken B cell line DT40:a novel tool for gene disruption experiments显示文摘 | Winding P Berchtold M W | 2001 | J Immunol Methods2001，249，： | 1 |
| 15 | High-yield secretion of recombinant gelatins by Pichia pastoris 显示文摘 | WERTEN M W T VAN DEN BOSCH T J WIND R D | 1999 | Yeast1999，15，： | 1 |
| 16 | High yield secretion of recombinant gelatins by Pichia Pastoris显示文摘 | Werten M W Vande Bosch T J Wind R D | 1999 | Yeast1999，15，11： | 1 |
| 17 | An isolate of Exserohilum turcicum virulent on maize inbreeds with resistance gene HtN显示文摘 | Windes J M Pederson W L | 1991 | Plant Disease1991，75，7： | 1 |
| 18 | The chicken B cell line DT40: a novel tool for gene disruption experiments 显示文摘 | WINDING P BERCHTOLD M W | 2001 | J Immunol Methods2001，249，： | 1 |
| 19 | An isolate of E3cserohilum turci- cure virulent on maize inbreeds with resistance gene HtN 显示文摘 | Windes J M Pederson W L | 1991 | Plant Disease1991，75，7： | 1 |
| 20 | A capacitance study of pseudo-fickian diffusion in glassy polymer coatings 显示文摘 | Wind M M Lenderink H J W | 1996 | Prog Org Coat1996，28，4： | 1 |
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