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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Levofloxacin: a therapeutic review显示文摘 | Steven M. Wimer Lori Schoonover Mark W. Garrison | 1998 | Clinical Therapeutics1998，，6： | 1 |
| 3 | Differences in memory processes between inbred mouse strains C57BL-6J and DBA-2J显示文摘 | Wimer RE Symington L Farmer H Schwartzkroin P | 1968 | J Comp Physiol Psychol1968，65，1： | 1 |
| 4 | Implications of the analogy between recombinant eytokine toxieifies and manifestations of hantavirus infections显示文摘 | WIMER BM | 1998 | Cancer Biother Radiopharm1998，13，： | 1 |
| 5 | PHA for aplastic anemias:the alpha but not the omega of mitogen therapies显示文摘 | Wimer B M | 1998 | Cancer Biother Radiopharm1998，13，2： | 1 |
| 6 | Mitogen immunotherapy for HIV infections exemplified by phytohemagglutinin and pokeweed mitogen显示文摘 | Wimer B M Mann P L | 2000 | Cancer Biother Radiopharm2000，15，6： | 1 |
| 7 | Levofloxacin: a therapeutic review显示文摘 | Wimer SM Schoonover L Garrison MW | 1998 | Clin Ther1998，20，6： | 1 |
| 8 | Characteristics of PHA-L4, the mitogenic isolectin of phytohemagglutinin, as an ideal biologic response modifier 显示文摘 | Wimer B M | 1990 | Mol Biother1990，2，1： | 1 |
| 9 | Levofloxacin: a therapeutic review显示文摘 | Schoonover L Garrison MW | 1998 | Clin Ther1998，20，： | 1 |
| 10 | Implications of the analogy between recombinant cytokine toxicities and manifestations of hantavirus infections 显示文摘 | Wimer BM | 1998 | Cancer Biother Radiopharm1998，13，3： | 1 |
| 11 | Dose Manage Reduce Crime? A Counterfactual Approach to Within-Individual Causal Effects显示文摘 | SAMPSON R J LAUB J H WIMER C | 2006 | Criminology2006，44，3： | 1 |
| 12 | Levofloxacin: a therapeutic review显示文摘 | Wimer SM Schoonover L Garrison ME | 1998 | Clin Ther1998，20，： | 1 |
| 13 | A new model of diffuse brain injury显示文摘 | Marmarou A Montasser A Wimer Van Den Brink | 2004 | J Neurosurg2004，80，2： | 1 |
| 14 | A methodology for constructing linear graph algorithms显示文摘 | Wimer T V Hedetniemi S T Laskar R | 1985 | Congressus Numerantium1985，50，： | 1 |
| 15 | A new model of diffuse brain injury in rats显示文摘 | Anthony Marmarou Montasser A Wimer Van Den Brink | 1994 | J Neurosurg1994，80，： | 1 |
| 16 | Athletic aggression: Perceived legitimacy and behavioral intentions in girl's high school basketball 显示文摘 | Ryan K R Williams J M Wimer B | 1990 | Journal of Sport & Exercise Psychology1990，12，： | 1 |
| 17 | Levofloxacin:a therapeutic review显示文摘 | Wimer SM Schoonover L Garrison ME | 1998 | Clin Ther1998，20，： | 1 |
| 18 | PHA for aplastic anemias: the alpha but not the o- mega of mitogen therapies 显示文摘 | WIMER B M | 1998 | Cancer Biother Radiopharm1998，13，3： | 1 |
| 19 | Levofloxaein: a therapeutic review 显示文摘 | Wimer SM Sehoonover L Garrison MW | 1998 | Clin Ther1998，20，： | 1 |
| 20 | The mouse prolac tin gene family locus 显示文摘 | Wimers D O Shao LJ Ain R | 2003 | 内分泌学杂志2003，144，： | 1 |
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