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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | 血清铁蛋白是非酒精性脂肪肝患者组织炎症严重程度和晚期肝纤维化的独立预测指标显示文摘非酒精性脂肪肝(nonalcoholicfattyliverdisease。NAFLD)是肝脏疾病最常见的病因.在美国人群中发病率可达20%。铁蛋白是肝脏储存铁的主要形式.原发性或继发性铁代谢紊乱都会增加肝脏铁蛋白的分泌.从而导致肝内和循环中铁蛋白水平的增加。研究表明.炎症刺激和氧化应激能上调血清铁蛋白(sel3.1mferriritin,SF)的表达,其作用可能是通过特殊的氧化剂作用于蛋白质转录和翻译阶段而实现的。 | Kowdley KV Belt P Wilson LA 罗光成 闫惠平 | 2013 | 北京医学2013，35，3： | 2 |
| 4 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 5 | Androgen re- ceptor gene mutations in X-linked spinal and bulbar muscular atrophy显示文摘 | La Spada AR Wilson EM Lubahn DB | 1991 | Nature1991，352，6330： | 1 |
| 6 | Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease显示文摘 | Kowdley KV Belt P Wilson LA | 2012 | Hepatology2012，55，1： | 1 |
| 7 | Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy 显示文摘 | La Spada APt Wilson EM Luhahn DB | 1991 | Nature1991，352，： | 1 |
| 8 | Parental transmission of type 2 diabetes: the Framingham Offspring Study 显示文摘 | Meigs JB Cupples LA Wilson PW | 2000 | Diabetes2000，49，12： | 1 |
| 9 | Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy 显示文摘 | La Spada AR Wilson EM Lubahn DB | 1991 | Nature1991，352，： | 1 |
| 10 | Self-perceived burden in chronic pain: relevance, prevalence, and pre-dictors显示文摘 | Kowal J Wilson KG Williams LA | 2012 | Pain2012，153，8： | 1 |
| 11 | Evidence for a gene influencing serum bilirubin on chromosome 2q telommere :a genomewide scan in the Framingham study 显示文摘 | Lin JP Cupples LA Wilson PWF | 2003 | Am J Hum Genet2003，72，： | 1 |
| 12 | A biomeehanieal study of regional endplate strength and cage morphology as it relates to structural interbody support 显示文摘 | Lowe TG Hashim S Wilson LA | 2004 | Spine2004，29，： | 1 |
| 13 | Systematic review of magnetic resonance imaging characteristics that affect treatment decision making and predict clinical outcome in patients with cer- vical spondylotic myelopathy 显示文摘 | Tetreauh LA Dettori JR Wilson JR | 1976 | Spine (Phila Pa 1976)1976，38，221： | 1 |
| 14 | The safety and effi- cacy of chloral hydrate sedation for pediatric ophthalmic proce- dures:a retrospective review 显示文摘 | Wilson ME Karaoui M Djasim LA | 2014 | J Pediatr Ophthalmol Strabis- mus2014，51，3： | 1 |
| 15 | Electrophysiologic findings after intravitreal bevacizumab ( Avastin ) treatment 显示文摘 | Maturi RK Bleau LA Wilson DL | 2005 | Retina2005，25，3： | 1 |
| 16 | Prospective blinded evaluation of computed tomographic colonography for screen detection of colorectal polyps显示文摘 | Johnson CD Harmsen WS Wilson LA | 2003 | Gastroenterology2003，125，： | 1 |
| 17 | Serum ferritin is an independent predictor of histologlc severity and advanced fibrosis in patients with nonalcoholic fattyliver disease显示文摘 | Kowdley KV Belt P Wilson LA | 2012 | Hepatology2012，55，1： | 1 |
| 18 | Cervical preparation for surgicalabortion between 12 and 18 weeks of gestation using vaginal misopros-tol and Dilapan-S显示文摘 | Wilson LC Meyn LA Creinin MD | 2011 | Contraception2011，83，6： | 1 |
| 19 | Urinalysis显示文摘 | Wilson LA | 2005 | Nurs Stand2005，19，： | 1 |
| 20 | Electrophysiologic findings after intravitreal bevacizumab (Avastin) treatment显示文摘 | Maturi R Bleau LA Wilson DL | 2006 | Retina2006，26，3： | 1 |
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