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4篇 您的检索式：作者名="Wiley Paul"

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		题名	作者	年代	出处	被引量
	1	iWarp:a 100-MOPS,LIW Microprocessor for Multicomputers 显示文摘	Peterson Craig Sutton James Wiley Paul	1991	IEEE Mi-cro1991，11，3：	1
	2	Alfal- fa yield and plant water relations with variable irrigation显示文摘	Grimes Donald W Wiley Paul L Sheesley W Robert	1992	Crop Science1992，32，6：	1
	3	Structure of nogalamycin 显示文摘	Paul F Wiley Ronald B Kelly E	1977	J Am Chem Soc1977，99，2：	1
	4	A novel GPCR mediates pancreatic cancer associated fibroblast-cancer cell interaction显示文摘OBJECTIVE Pancreatic ductal adenocarcinoma(PDAC),a lethal cancer in need of new,effective therapies,has a unique tumor microenvironment characterized by a dense fibrotic stroma(desmoplasia)that is generated by pancreatic cancer-associated fibroblasts(PCAFs)derived from pancreatic stellate cells(PSCs)and pancreatic fibroblasts(PFs).METHEDS and RESULTS Hypothesizing that G protein-coupled receptors(GPCRs)may regulate PCAFs,we used an unbiased GPCRomic array approach to compare GPCR expression in PCAFs,PFs and PSCs and identified 82 GPCRs commonly expressed by PCAFs derived from primary tumors of five PDAC patients.We discovered that PCAFs have increased expression of numerous GPCRs,in particular a GPCR with much higher expression in PCAFs compared to both PFs and PSCs.Immunohistochemistry revealed increased expression of this GPCR in PDAC tumors.Co-culture of PSCs with PDAC cells or incubation with TNFαinduced its expression.Activation of the GPCR in PCAF sincreased expression of interleukin-6(IL-6)via a cA MP/PKA/CREB signaling pathway.GPCR knockdown with siR NA diminished IL-6 production and secretionby PCAFs and ability of PCAF conditioned media to enhance proliferation of PDAC cells.CONCLUSION We conclude that PDAC cells induce expression by PCAFs of a novel GPCR,resulting in increased IL-6 production by PCAFs and promotion of PDAC cell proliferation.This PCAF-expressed GPCR thus contributes to PDAC cell-PCAF interaction and as such,may be a novel therapeutic target for PDAC tumors.	Shu Z WILEY Krishna SRIRAM Wen-jing LIANG Sarah E CHANG Randall FRENCH Thalia MCCANN Hiroshi NISHIHARA Andrew M LOWY Paul A INSEL	2017	中国药理学与毒理学杂志2017，31，10：	0

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