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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 3 | Editorial on hemoglobin A1c, blood pressure, and lowdensity lipoprotein cholesterol goals in diabetics显示文摘The American Diabetes Association (ADA) 2013 guidelines state that a reasonable hemoglobin A1c goal for many nonpregnant adults with diabetes is less than 7.0% a hemoglobin A1c level of less than 6.5% may be considered in adults with short duration of diabetes, long life expectancy, and no significant cardiovascular disease if this can be achieved without significant hypoglycemia or other adverse effects of treatment. A hemoglobin A1c level less than 8.0% may be appropriate for patients with a history of severe hypoglycemia, limited life expectancy, advanced macrovascular and microvascular complications, extensive comorbidities, and long-standing diabetes in whom the hemoglobin A1c goal is difficult to attain despite multiple glucoselowering drugs including insulin. The ADA 2013 guidelines recommend that the systolic blood pressure in most diabetics with hypertension should be reduced to less than 140 mmHg. These guidelines also recommend use of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in the treatment of hypertension in diabetics unless they are pregnant. Diabetics at high risk for cardiovascular events should have theirserum low-density lipoprotein (LDL) cholesterol lowered to less than 70 mg/dL with statins. Lower-risk diabetics should have their serum LDL cholesterol reduced to less than 100 mg/dL. Combination therapy of a statin with either a fibrate or niacin has not been shown to provide additional cardiovascular benefit above statin therapy alone and is not recommended. Hypertriglyceridemia should be treated with dietary and lifestyle changes. Severe hypertriglyceridemia should be treated with drug therapy to reduce the risk of acute pancreatitis. | Wilbert S Aronow | 2013 | World Journal of Cardiology2013，5，5： | 2 |
| 4 | Utilization of lipid-lowering drugs in elderly persons with increased serum low-density lipoprotein cholesterol associated with coronary artery disease,symptomatic peripheral arterial disease,prior stroke,or diabetes mellitus before and after an educational program on dyslipidemia treatment显示文摘 | Subrato Ghosh Wilbert S Aronow | 2003 | The journals of gerontology2003，58，5： | 1 |
| 5 | Increased plasma homocysteine is an independent predictor of new atherothrombotic brain infarction in older persons显示文摘 | Wilbert S Aronow Chul Ahn Hal Gutstein | 2000 | The American Journal of Cardiology2000，，5： | 1 |
| 6 | Comparison of acute coronary syndromes in men versus women >70 years of age显示文摘 | Woodworth S Nayak D Wilbert S | 2002 | The American Journal of Cardiology2002，90，10： | 1 |
| 7 | Ambulatory pulmonary artery pressure monitoring in advanced heart failure patients显示文摘Heart failure(HF) is an emerging epidemic associate with significant morbidity,mortality,and health care expenditure. Although there were major advances in pharmacologic and device based therapies for the management of HF,mortality of this condition remains high. Accurate monitoring of HF patients for exacerbations is very important to reduce recurrent hospitalizations and its associated complications. With the failure of clinical signs,tele-monitoring,and laboratory bio-markers to function as early markers of HF exacerbations,more sophisticated techniques were sought to accurately predict the circulatory status in HF patients in order to execute timely pharmacological intervention to reduce frequent hospitalizations. Cardio MEMSTM(St. Jude Medical,Inc.,Saint Paul,Minnesota) is an implantable,wireless pulmonary arterial pressure(PAP) monitoring system which transmits the patient's continuous PAPs to the treating health care provider in the ambulatory setting. PAP-guided medical therapy modification has been shown to significantly reduce HF-related hospitalization and overall mortality. In advanced stages of HF,wireless access to hemodynamic information correlated with earlier left ventricular assist device implantation and shorter time to heart transplantation. | Srikanth Yandrapalli Anoshia Raza Sohaib Tariq Wilbert S Aronow | 2017 | World Journal of Cardiology2017，9，1： | 1 |
| 8 | Genetic mapping offloral traits associated with reproductive isolation in rnonkeyfolw-ers ( Mimulus ) 显示文摘 | Bradshaw H D Wilbert S M Otto K G | 1995 | Nature1995，376，： | 1 |
| 9 | Genetic strategies for enhancing phytoremediation 显示文摘 | STOMP A M HAN K H WILBERT S | 1994 | Ann NY Acad Sci1994，721，： | 1 |
| 10 | Cardiacamyloidosis approaches to diagnosis and management 显示文摘 | Desai H Wilbert S Stephen J | 2010 | Cardiol Rev2010，18，1： | 1 |
| 11 | ACCF/AHA 2011 expert consensus document on hypertension in the elderly显示文摘 | Maciei Bnach Wilbert S Aronow | 2011 | J Am College Cardiology2011，57，20： | 1 |
| 12 | Genetic stra- tegies for enhancing phytoremediation显示文摘 | Stomp A M Han K H Wilbert S | 1994 | Ann N Y Acad Sci1994，721，： | 1 |
| 13 | Cardiac amyloidosis approaches to diagnosis and management显示文摘 | DESAI H WILBERT S STEPHEN J | 2010 | Cardiol Rev2010，18，： | 1 |
| 14 | Operational performance of the TIMED doppler interferometer (TIDI) 显示文摘 | WILBERT R S RICK J N TIMOTHY L K | 2003 | Proceedings of SPIE2003，5175，： | 1 |
| 15 | Comparison of acute coronary syndromes in men versus women>70 years of age 显示文摘 | Woodwrth S Nayak D Wilbert S | 2002 | Am J Cardikl2002，90，10： | 1 |
| 16 | Prevalence of left ventricular hypertrophy in persons with and without obstructive sleep apnea显示文摘 | Rishi S Wilbert S A Rasham S | 2006 | Cardiol Rev2006，14，4： | 1 |
| 17 | Variance of streaming potential measurements 显示文摘 | Wilbert M C Delagah S Pellegrino J | 1999 | J Membr Sci1999，161，： | 1 |
| 18 | ACCF/AHA 2011 Expert Consensus Document on Hypertension in the elderly显示文摘 | WILBERT S A JEROME L F CARL J R | 2011 | J Am Coll Cardiol2011，57，： | 1 |
| 19 | Ciliated protozoa (Ciliophora) from Arctic sea ice显示文摘 | AGATHA S SPINDLER M WILBERT N | 1993 | Acta Protozool1993，32，： | 1 |
| 20 | Toxicogenomics Concepts and Applications to Study Hepatic Effects of Food Additives and Chemicals显示文摘 | ROB S WILBERT H ANNE K | 2005 | Toxicology and Applied Pharmacology2005，207，： | 1 |
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