|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Across towns and across times: library service to young people in rural libraries显示文摘 | Wigg R | 1995 | Illonis1995，，： | 1 |
| 3 | The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis 显示文摘 | Wigg A J Roberts-Thomson I C Dymock R B | 2001 | Gut2001，48，2： | 1 |
| 4 | Using gravestones to assess changing rates of weathering in the United Kingdom显示文摘 | COOKE R U INKPEN R J WIGGS G F S | 1995 | Earth Surface Processes and Landforms1995，20，6： | 1 |
| 5 | Using gravestones to assess changing rates of weathering in the United Kingdom显示文摘 | Cooke R U Inkpen R J Wiggs G F S | 1995 | Earth Surface Processes and Landforms1995，20，6： | 1 |
| 6 | The dynamic effects of moisture on the entrainment and transport of sand by wind 显示文摘 | Wiggs G F S Bullard J E Atherton R J | 2004 | Geomorphology2004，59，14： | 1 |
| 7 | Numerical modelling of airflow over an idealised transverse dune 显示文摘 | PARSONS D R WIGGS G F S | 2004 | Envi- ronmental Modelling & Software2004，19，： | 1 |
| 8 | Role of genetic factors in the etiology of juvenile-onset myopia based on a longitudinal study of refractive error显示文摘 | Pacella R McLellan J Grice K Del Bono EA Wiggs JL Gwiazda JE | 1999 | Optom Vis Sci1999，76，6： | 1 |
| 9 | Explosivetesting of full thickness precracked weldments 显示文摘 | Gifford L N Carlberg J R Wiggs A J | 1990 | ASTMSpecial Technical Publication1990，，1074： | 1 |
| 10 | The role of small intestinal overgrowth, intestinal permeability, endotoxaemia, and tumor necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis 显示文摘 | Wigg A J Roberts-Thomson I C Dymock R B | 2001 | Gut2001，48，2： | 1 |
| 11 | Serotonin 1A Receptors, epression, and Memory in Temporal Lobe Epilepsy显示文摘 | William H Theodore 1 Edythe A Wiggs Ashley R Martinez | 2012 | Epilepsia2012，53，1： | 1 |
| 12 | Port Pirie cohort study: environmental exposure to lead and children's abilities at the age of 4 years显示文摘 | McMichel A J Baghurst P A Wigg N R | 1988 | New Engl J Med1988，319，8： | 1 |
| 13 | The dynamic effect of moisture on the entrainment and transport of sand by wind 显示文摘 | Wiggs G F S Baird A J Atherton R J | 2004 | Geomorphology2004，59，： | 1 |
| 14 | Preschool hearing screening:Evaluation of a parental questionnaire显示文摘 | M S Gold N R Wigg | 1997 | Journal of Paediatrics & Child Health1997，33，6： | 1 |
| 15 | The dynamic effect of moisture on the entrainment and transport of sand by wind 显示文摘 | Wiggs G F S Baird A J Atherton R J | 2004 | Geomorphology2004，59，： | 1 |
| 16 | Attention deficit hyperactivity disorder and the gene for dopamine beta-hydroxyylase显示文摘 | Wigg K Zai G Schachar R | 2002 | Am J Psychiatry2002，159，： | 1 |
| 17 | A chronic disease management model for chronic liver failure 显示文摘 | Wigg AJ Chinnaratha MA Wundke R | 2015 | Hepatology2015，61，2： | 1 |
| 18 | Numerical modeling of flow structures over idealized transverse aeolian dunes of varying geometry显示文摘 | Parsons D R Walker 1 J Wiggs G F S | 2004 | Geomorphology2004，59，14： | 1 |
| 19 | Numerical modelling of airflow over an idealized transverse dune 显示文摘 | PARSONS D R WIGGS G F S WALKER I J | 2004 | Environ M odell Softw2004，19，2： | 1 |
| 20 | Numerical modelling of flow structure over an idealized transverse Aeolian dunes of varying geometry 显示文摘 | PARSONS D R WALKER I J WIGGS G F S | 2004 | Geomorphology2004，59，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员