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99篇 您的检索式:作者名="Wielenga"
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1European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms显示文摘The BCR/ABL fusion gene or the Ph^1-chromosome in the t(9;22)(q34;q11)exerts a high tyrokinase acticity,which is the cause of chronic myeloid leukemia(CML).The1990 Hannover Bone Marrow Classification separated CML from the myeloproliferative disorders essential thrombocythemia(ET),polycythemia vera(PV)and chronic megakaryocytic granulocytic myeloproliferation(CMGM).The 2006-2008 European Clinical Molecular and Pathological(ECMP)criteria discovered 3variants of thrombocythemia:ET with features of PV(prodromal PV),'true'ET and ET associated with CMGM.The 2008 World Health Organization(WHO)-ECMP and 2014 WHO-CMP classifications defined three phenotypes of JAK2^(V617F)mutated ET:normocellular ET(WHO-ET),hypercelluar ET due to increased erythropoiesis(prodromal PV)and ET with hypercellular megakaryocytic-granulocytic myeloproliferation.The JAK2^(V617F)mutation load in heterozygous WHO-ET is low and associated with normal life expectance.The hetero/homozygous JAK2^(V617F)mutation load in PV and myelofibrosis is related to myeloproliferative neoplasm(MPN)disease burden in terms of symptomaticsplenomegaly,constitutional symptoms,bone marrow hypercellularity and myelofibrosis.JAK2 exon 12mutated MPN presents as idiopathic eryhrocythemia and early stage PV.According to 2014 WHO-CMP criteria JAK2 wild type MPL^(515)mutated ET is the second distinct thrombocythemia featured by clustered giant megakaryocytes with hyperlobulated stag-horn-like nuclei,in a normocellular bone marrow consistent with the diagnosis of'true'ET.JAK2/MPL wild type,calreticulin mutated hypercellular ET appears to be the third distinct thrombocythemia characterized by clustered larged immature dysmorphic megakaryocytes and bulky(bulbous)hyperchromatic nuclei consistent with CMGM or primary megakaryocytic granulocytic myeloproliferation.Jan Jacques Michiels Fransje Valster Jenne Wielenga Katrien Schelfout Hendrik De Raeve 2015World Journal of Hematology2015,4,3:3
2Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘Wielenga VJ Heider KH Offerhaus GJ 1993Cancer Res1993,53,20:1
3Expression of CD44 variant poteins in humen colorectal cancer related to tumor progression 显示文摘 Heider KH Offerhaus GJA 1993Cancer Res1993,53,22:1
4Cryopreservation of ovarian tissue for fertility preserva-tion:no evidence of malignant cell contamination in ovariantissue from patients with breast cancer显示文摘Rosendahl M Timmermans Wielenga V Nedergaard L 0,,6:1
5Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis显示文摘Mulder JW Wielenga VJ Polak MM 1995Cut1995,36,5:1
6Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met显示文摘VOORT R TAHER T I WIELENGA V M 1999J Biol Chem1999,274,10:1
7Severe infective endocarditis due to Neisseria sic- ca: case report and review of literature显示文摘JEURISSEN A STROY J P WIELENGA R P 2006Acta Clin Belg2006,61,:1
8Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorgenesis显示文摘Mulder JWR Wielenga VTM Polak MM 1995Gut1995,36,1:1
9Experssion of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘Wielenga V J Heider KH Offerhaus G J 1993Caner Res1993,53,20:1
10Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer显示文摘 ROBBERT VAN DER VOORT TAHER E I TAHER 2000American Journal of Pathology2000,157,:1
11CD44 expression predicts disease outcorhe in localized large B cell lymphoma显示文摘Drillenburg P Wielenga VJ Kramer MH 1999Leukemia1999,13,9:1
12Safety and effects of physical training in chronic heart failure, results of the chronic heart failure and graded exercise study显示文摘Wielenga RP Huissveld IA Bol E et ai 1999Eur Heart J1999,20,12:1
13Heparan sulfate- modified CD44 promotes hepatocyte growth factor/scatter factor- induced signal transduction through the receptor tyrosion kinasc c-Met 显示文摘Van der Voort R Taher TE Wielenga VJ 1999J Biol Chem1999,274,10:1
14Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘 Heider KH Offerhaus GJ 1993Cancer Res1993,53,20:1
15Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘WIELENGA V J HEIDER K H OFFERHAUS G J 1993Cancer Res1993,53,20:1
16Experssion of CD44variant proteins in human colorectal cancer is related to tumor pro-gression显示文摘Wielenga VJ Heider KH Offerhaus GJ 1993Caner Res1993,53,20:1
17CD44 expression predicts disease outcome in localized large B cell lymphoma显示文摘Drillenburg P Wielenga VJ Kramer MH 1999Leukemia1999,13,9:1
18Expression of CD44 varient proteins in human colorected cancer is related to tumour progression显示文摘 Heider KH Offerhaus JA 1993Cancer Res1993,53,20:1
19Expression of CD44 variant proteins in human eolorectal cancer is related to tumor progression显示文摘 Heider KH Offerhaus JA 1993Cancer Res1993,53,:1
20Develop-rnent and growth in very preterm infants in relation to NIDCAP in a Dutch NICUtwo years of follow-up显示文摘Wielenga JM Smit BJ Merkus MP 2009Acta Paediatr2009,98,2:1
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