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| 1 | 应用mTOR抑制剂西罗莫司治疗淋巴管畸形:系统评价显示文摘背景:广泛性淋巴管畸形是能引起破坏性并发症的低流量脉管畸形,这一畸形的治疗充满挑战性。本系统评价介绍了目前西罗莫司在治疗广泛性淋巴管畸形患者中的应用。方法:在MEDLINE和谷歌学术中检索自2017年7月以来有关西罗莫司治疗淋巴管畸形的研究。检索关键词包括"淋巴管畸形"、"淋巴管瘤"、"囊性水瘤"、"脉管畸形"、"低流量畸形"、"西罗莫司"、"雷帕霉素"和"mTOR抑制剂"。 | Wiegand S Wichmann G Dietz A 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，4： | 13 |
| 2 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 3 | Oral citrus seed extract显示文摘 | IONESCU G KIEHL R WICHMANN K F | 1991 | Journal of Orthomolecular Medicine1991，5，： | 1 |
| 4 | Promiscuity in transgenic plants显示文摘 | Bergelson J Purrington CB Wichmann G | 1998 | Nature1998，395，： | 1 |
| 5 | Influence of different carbon nanotubes on the mechanical properties of epaxmatrix composites-a comparative study显示文摘 | GOJNY F H WICHMANN M H G FIEDLER B | 2005 | Composites Science and Technology2005，65，15116： | 1 |
| 6 | Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘 | Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J | | 0，，12： | 1 |
| 7 | Carbon nanotube-reinforced epoxy-composites:Enhanced stiffness and fracture toughness at low nanotube content显示文摘 | GOJNY F H WICHMANN M H G KOPKE U | | 0，，15： | 1 |
| 8 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 9 | Inflammatory activity in river-water samples 显示文摘 | Wichmann G Daegelrnann C Herbarth O | 2004 | Earth and Environmental Science2004，19，6： | 1 |
| 10 | Long-term results after pulmonary resection of renal cell carcinoma metastases显示文摘 | Piltz S Meimarakis G Wichmann MW | 2002 | Ann Thorac Surg2002，73，4： | 1 |
| 11 | Evaluation and identification of electrical and thermal conduction mechanisms in carbon nanotuhe/epoxy composites显示文摘 | Gojny F H Wichmann M H G Fiedler B | 2006 | Polymer2006，47，： | 1 |
| 12 | Carbon Nanotube-reinforced Epoxy-composites:Enhanced Stiffness and Fracture Toughness at Low Nanotube Content显示文摘 | Gojny F H Wichmann M H G Kopke U | 2004 | Composites Science and Technology2004，64，15： | 1 |
| 13 | The mycotoxins citrinin, gliotoxin, and patulin affect interferon--,/rather than interleukin-4 production in human blood cells显示文摘 | G Wichmann O Herbarth I Lehmann | 2002 | Environmental Toxicology2002，17，3： | 1 |
| 14 | Carbon nanotube reinforced epoxy composites enhanced stiffness and fracture toughness at low nanotube contents显示文摘 | Gojny F H Wichmann M H G Kopke U Fiedler B Schulte K | 2004 | Composites Science and Technology2004，64，： | 1 |
| 15 | Promiscuity in transgenicplants显示文摘 | BERGELSON J PURRINGTON C B WICHMANN G | 1998 | Nature1998，，395： | 1 |
| 16 | Influence of nano-modification on the mechanical and electri- cal properties of conventional fibre-reinforced composites 显示文摘 | GOJNY F H WICHMANN M H G FIEDLER B | 2005 | Composites Part A2005，36，11： | 1 |
| 17 | Interleukin-17- producing T helper cells in autoimmunity显示文摘 | Hemdan NY Birkenmeier G Wichmann G | 2010 | Autoimmun Rev2010，9，11： | 1 |
| 18 | The cytotoxic effects of the organophosphates chlorpyrifos and diazinon differ from their immunomodulating effects 显示文摘 | Oostingh GJ Wichmann G Schmittner M | 2009 | J Immunotoxicol2009，6，2： | 1 |
| 19 | Glass-fibre- reinforced composites with enhanced mechanical and electrical properties-benefits and limitations of a nanoparticle modified matrix 显示文摘 | Wichmann M H G Sumfleth J Gojny F H | 2006 | Engineering Fracture Mechanics2006，73，16： | 1 |
| 20 | IDH1R132H mutation causes a less aggressive phenotype and radiosensitizes human malignant glioma cells independent of the oxygenation status显示文摘 | Kessler J Güttler A Wichmann H | 2015 | Radiother Oncol2015，29，15： | 1 |
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