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| 1 | Partial Protection by Lipoic Acid Against Carboplantin-induced Ototoxicity in Rats显示文摘Objective To investigate the alterations in auditory brainstem evoked responses (ABRs) and the changes of carboplatin-induced ototoxicity in the cochlear oxidant/antioxidant systems and otoprotection by an antioxidant lipoate. Methods Male wistar rats were divided into four groups and treated as follows: 1) vehicle (saline) control, 2) carboplatin (256 mg/kg, i.p.), 3) lipoate (100 mg/kg, i.p.), 4) lipoate + carboplatin. Post-treatment ABRs were performed after four days and rats were sacrificed with their cochleae harvested and analyzed. Results Carboplatin significantly elevated ABR threshold above the pretreatment thresholds. Lipoate+carboplatin treated rats showed decreased elevation of hearing threshold. Carboplatin significantly depleted cochlear reduced to oxizized glutathione (GSH/GSSG) ratio, whereas lipoate+carboplatin treatment increased GSH/GSSG ratio. Carboplatin significantly decreased cochlear copper zinc-superoxide dismutase (CuZn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST) activities and enzyme protein expressions and a significant increase in Mn-SOD activity, protein expression and malondialdehyde (MDA) level. Cochlear antioxidant enzyme activities, enzyme protein expressions and MDA level were partially restored in lipoate+carboplatin treated rats, compared to carboplatin alone. Conclusion Carboplatin-induced ototoxicity is related to impairment of cochlear antioxidant system and otoprotection conferred by lipoate is associated with partial sparing of the cochlear antioxidant defense system. | KAZIM HUSAIN CRAIG WHITWORTH SATU M. SOMANI LEONARD P. RYBAK | 2005 | Biomedical and Environmental Sciences2005，18，3： | 3 |
| 2 | Locoregional Recurrence After Sentinel Lymph Node Dissection With or Without Axillary Dissection in Patients With Sentinel Lymph Node Metastases: The American College of Surgeons Oncology Group Z0011 Randomized Trial显示文摘 | Armando E. Giuliano Linda McCall Peter Beitsch Pat W. Whitworth Peter Blumencranz A. Marilyn Leitch Sukamal Saha Kelly K. Hunt Monica Morrow Karla Ballman | 2010 | Annals of Surgery2010，，3： | 2 |
| 3 | Attitudes to voluntarily counseling and testing for HIV among pregnant women in rural south - west Uganda 显示文摘 | Pool R Nyanzi S Whitworth JA | 2001 | AIDS care2001，13，5： | 1 |
| 4 | DNA barcoding cannot reliably identify species of the blowfly genus Protocalliphora ( Diptera = Calliphoridae) 显示文摘 | WHITWORTH T L DAWSON R D MAGALON H | 2007 | Proc R Soc Lond2007，274，1619： | 1 |
| 5 | Laser skin resurfacing with the Q-switched Nd:YAG laser显示文摘 | Goldberg DJ Whitworth J | 1997 | Dermatol Surg1997，23，： | 1 |
| 6 | Coronal leakage of sealer-only backfill: An in vitro evaluation显示文摘 | Whitworth JM Baco L | 2005 | J Endod2005，31，4： | 1 |
| 7 | Low-risk palpable-hreast masses removed using a vacuum-assisted handheldHevi^e显示文摘 | Fine RE Whitworth PW Kim JA T | 2003 | Am J Surg2003，186，4： | 1 |
| 8 | Percutaneous removal of benign breast masses using a vacuum-assisted hand-held de- vice with ultrasound guidance显示文摘 | Fine RF Boyd BA Whitworth PW | 2002 | Am J Surg2002，184，4： | 1 |
| 9 | 2003 World Health Organization(WHO)/International Society of Hypertension(ISH)statement on management of hypertension显示文摘 | Whitworth JA World Health Organization International Society of Hypertension Writing Group | 2003 | J Hypertens2003，21，11： | 1 |
| 10 | Ef- fect of antibody on the Rickettsia-host cell interaction 显示文摘 | FENG HM WHITWORTH T VSEVOLOD P | 2004 | Infect Immunol2004，72，： | 1 |
| 11 | Progression of renal failure: the role of hypertension显示文摘 | Whitworth J A | 2005 | Ann Acad Med Singapore2005，34，1： | 1 |
| 12 | 2003 World Health Organization (WHO)/international Society of Hypension (ISH) statement on management of hypertension 显示文摘 | Whitworth JA World Health Organization International Society of Hypertension Writing Group | 2003 | J Hypertens2003，21，11： | 1 |
| 13 | Vitamin E reduces cisplatin ototoxicity显示文摘 | Kalkanis JG Whitworth C Rybak LP | 2004 | Laryngoscope2004，114，： | 1 |
| 14 | Social support, anxiety and depression after chemotherapy for ovarian cancer : a prospective study显示文摘 | Hipkins J Whitworth M Tarrier N | 2004 | Br J Health Psychol2004，9，4： | 1 |
| 15 | Application of the point stress criterion to the failure of composite pinned joints 显示文摘 | Whitworth H A Aluko O Tomlinson N A | 2008 | Engineering Fracture Mechanics2008，75，： | 1 |
| 16 | Implementations and tests of Gedunov-type particle hydrodynamic显示文摘 | Cha S H Whitworth A P | 2003 | Monthly Notices of the Royal Astronomical Society2003，340，： | 1 |
| 17 | Keys to genera and species of blow flies (Diptera: Calliphoridae) of America north of Mexico显示文摘 | WHITWORTH T | 2006 | Proceedings of the Entomological Society of Washington2006，3，： | 1 |
| 18 | Acute allograft glomerulopathy associated with CMV viraemia 显示文摘 | Browne G Whitworth C Bellamy C Ogilvie M M | 2001 | Nephrol Dial Transplant2001，16，4： | 1 |
| 19 | Interim results from the fibroadenoma cryoablation treatment registry显示文摘 | Nurko J Mabry CD Whitworth P | 2005 | Am J Surg2005，190，： | 1 |
| 20 | Adrenal neuropeptides: Regulation and interaction with ACTH and other adrenal regula- tors显示文摘 | Whitworth EJ Kostio Renshaw D | 2003 | Microse Res Tech2003，61，： | 1 |
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