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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Meat tenderness and muscle growth: is there any relationship? 显示文摘 | Koohmaraie M Kent M P Shackelford S D Veiseth E Wheeler T L | 2002 | Meat Science2002，62，： | 1 |
| 3 | Urine detection of survivin and diagnosis of bladder cancer显示文摘 | Smith S D Wheeler M A Plescia J | 2001 | JAMA2001，285，： | 1 |
| 4 | Sepsis in the Pediatric Cardiac Intensive Care Unit显示文摘 | Wheeler D S Jeffries H E Zimmerman J J | 2011 | WorldJPediatr Congenit Heart Surg2011，2，3： | 1 |
| 5 | Expression profiles during honeybee caste de- termination 显示文摘 | Evans J Wheeler D | 2000 | Genome Biology2000，，2： | 1 |
| 6 | Microstructural Tomography of a NiTo Cr20 Allo Superalloy Using Focused Ion Beam Microscopy 显示文摘 | Uchic M D De Graef M Wheeler R | 2009 | Ultramicroscopy2009，109，10： | 1 |
| 7 | Effect of alkali treatment on intake and digestion of barley straw by beef steers显示文摘 | COOMBE J B DINUIS D A WHEELER W E | 1979 | Journal of Animal Science1979，49，1： | 1 |
| 8 | The effects of Piedmontese inheritance and myostatin genotype on the palatalility of longissimus thoracic,guteus medius,semimembranosus and biceps femoris 显示文摘 | Wheeler T L Shackelford S D Casas E | 2001 | Animal Science2001，79，12： | 1 |
| 9 | Management of acute pulmonary hemorrhage in children显示文摘 | Sidman J D Wheeler W B Cabalka A K | | 0，，： | 1 |
| 10 | Translocation of two glucose transporters in heart: effects of rotenone, uncouplers,workload, palmitate, insulin and anoxia显示文摘 | WHEELER T J FELL R D HAUCK M A | 1994 | Biochim Biophys Acta1994，1196，2： | 1 |
| 11 | A multicenter phase Ⅱ trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patientswith previously treated metastatic breast cancer 显示文摘 | MILLER K D TRIGO J M WHEELER C | 2005 | Clin Cancer Res2005，11，9： | 1 |
| 12 | Serum uric acid and coronary heart disease in 9 458 incident cases and 155 084 controls: prospective study and meta-analysis显示文摘 | Jeremy G Wheeler Kelsey D M Juzwishin | 2005 | Plos Med2005，2，3： | 1 |
| 13 | Database resources of the National Center for Biotechnology Information显示文摘 | Wheeler D L Barrett T Benson D A | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 14 | Competition belwl~nhydrilla vertieillata and vallisneria Americana as influenced by soil fertility显示文摘 | Van T K Wheeler G S Center T D | 1999 | Aquatic Botany1999，11，6： | 1 |
| 15 | Gender differences in early alcohol-induced liver injury: role of CD14, NF- κ B, and TNF- α 显示文摘 | KONO H WHEELER M D RUSYN I | 2000 | Am J Physiol Gastrointest Liver Physiol2000，278，4： | 1 |
| 16 | Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error显示文摘 | Thibos LN Wheeler W Horner D | 1997 | Optom Vis Sci1997，74，： | 1 |
| 17 | The duration and rate of grain growth,and harvest index of wheat in response to tempera ture 显示文摘 | Wheeler T R Hong T D | 1996 | Ea''p Bot1996，47，： | 1 |
| 18 | Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats 显示文摘 | Wheeler M D Kono H Rusyn I | 2001 | Gastroenterology2001，120，5： | 1 |
| 19 | Power vectors:an application of Fourier analysis to the description and statistical analysis of re- fractive error显示文摘 | Thibos LN Wheeler W Homer D | 1997 | Optom Vis Sci1997，74，5： | 1 |
| 20 | Auditory integration training and other sound therapies for autism spectrum disorders: A systematic review 显示文摘 | Sinha Y Silove N Wheeler D | 2006 | Arch Dis Child2006，91，12： | 1 |
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