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| 1 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 2 | Lack of MD-2 expressionin human corneal epithelial cells is an underlying mechanism oflipopolysaccharide (LPS) unresponsiveness显示文摘 | Zhang J Kumar A Wheater M Yu FS | 2009 | Immunol CellBiol2009，87，2： | 1 |
| 3 | Uncertainty in groundwater flow and transport modeling-a stochastic analysis of well-protection zones显示文摘 | Wheater H S Tomplins J A van Leeuwen M | 2000 | Hydrological Processes2000，14，11： | 1 |
| 4 | Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK 显示文摘 | Qiu P Wheater M K Qiu Y | 2011 | FASEB J2011，25，6： | 1 |
| 5 | The role of MNK proteins and elF4E phosphorylation in breast cancer cell proliferation and survival显示文摘 | WHEATER M J JOHNSON P W BLAYDES J P | 2010 | Cancer Biol Ther2010，10，7： | 1 |
| 6 | The design and implementation of arjuna显示文摘 | PARRINGTON G D SHRIVASTAVA S K WHEATER S M | 1995 | Computing Systmes1995，8，2： | 1 |
| 7 | The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival显示文摘 | Wheater M J Johnson PW Blaydes JP | 2010 | Cancer Biol Ther2010，10，7： | 1 |
| 8 | Maintaining corneal integrity how the“window”stays clear显示文摘 | Kurpakus Wheater M Kernacki KA Hazlett LD | 2001 | Prog Histochem Cytochem2001，36，3： | 1 |
| 9 | The design and implementation of a framework for configurable software显示文摘 | STUART M WHEATER MARK C LITTLE | | 0，，： | 1 |
| 10 | Clinical outcomes following neoadjuvant cisplatin-based chemotherapy for bladder cancer in elderly compared with younger patients显示文摘 | Chau C Wheater M Geldart T | 2015 | Eur J Cancer Care (Engl)2015，24，2： | 1 |
| 11 | Immunosuppression for ipilimumab-related toxicity can cause pneumonia but spare antiamaor immune control显示文摘 | Arriola E Wheater M Krishnan R | 2015 | Oncoimmunology2015，4，10： | 1 |
| 12 | The design and implementation of arjuna显示文摘 | PARRINGTON G D SHRIVASTAVA S K WHEATER S M | 1995 | Computing Systmes1995，8，2： | 1 |
| 13 | Architecture Support for Dynamic Reconfiguration of Large Scale Distributed Applications显示文摘 | S M Wheater | 1998 | IEEE1998，，： | 1 |
| 14 | Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide ( LPS ) unresponsiveness 显示文摘 | Zhang J Kumar A Wheater M Yu FS | 2009 | Immunol Cell Biol2009，87，2： | 1 |
| 15 | The role of MNK proteins and elF4E phosphorylation in breast cancer cell proliferation and survlval显示文摘 | WHEATER M J JOHNSON P W BLAYDES J P | 2010 | Cancer Biol Ther2010，10，7： | 1 |
| 16 | Evaluation of the rainfall component of a weather generator for climate impact studies显示文摘 | Elshamy M E Wheater H S Gedney N | 2006 | Journal of Hydrology2006，326，14： | 1 |
| 17 | The significance of spatial rainfall representation for flood runoff estimation: A numerical evaluation based on the Lee catchment, UK 显示文摘 | Segond M L Wheater H S Onof C | 1997 | Journal of Hydrology1997，347，12： | 1 |
| 18 | Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness显示文摘 | Zhang J Kumar A Wheater M | 2009 | Immunol Cell Biol2009，87，： | 1 |
| 19 | Conservative mixing of water sources,analysis of the behavior of the Allt a'Mharcaidh catchment显示文摘 | Wheater H S Beck M B | 1990 | Journal of Hydrology1990，116，： | 1 |
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