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| 1 | A Pid3 allele from rice cultivar Gumei2 confers resistance to Magnaporthe oryzae显示文摘瑞斯强风,由 Magnaporthe oryzae 引起了,是大多数破坏疾病之一。用基于地图的策略并且在 silico 途径,我们孤立新米饭(Oryza sativa L.) Pid3 的强风抵抗等位基因,指明的 Pi25,从稳定的强风抵抗栽培变种 Gumei2。在表示上分析和互补测试证明 Pi25 授与强风抵抗到 M。oryzae 孤立 js001-20。顺序分析证明 Pi25 是有与在核苷酸位置的 Pid3 相比的单个核苷酸替换的 2772 核苷酸的 intronless 基因 459 并且述词地编码了典型卷的 coilnucleotide 绑定 siteleucine 有到 Pid3 的 100% 身份的 924 氨基酸剩余的富有的重复(CCNBSLRR ) 蛋白质通常认为的蛋白质。在 Nipponbare 的易受影响的等位基因 pi25 在核苷酸位置包含了一个胡说八道变化 2209 与 736 氨基酸剩余导致截断的蛋白质。另外,导致 10 氨基酸替换的 14 核苷酸替换在 Pi25 和在上游的 pi25 之间被识别在易受影响的等位基因的早熟的站 codon。尽管 Pi25/Pid3-mediated 抵抗的机制需要进一步被调查,等位基因的隔离将在经由转基因的途径引起节目的米饭强风抵抗便于 Pi25/Pid3 的利用,标记帮助选择。 | Jie Chen Yongfeng Shi Wenzheng Liu Rongyao Chai Yaping Fu Jieyun Zhuang Jianli Wu | 2011 | Journal of Genetics and Genomics2011，38，5： | 45 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | Distribution and geological significance of 17α(H)-diahopanes from different hydrocarbon source rocks of Yanchang Formation in Ordos Basin显示文摘Based on GC-MS testing data of many saturated hydrocarbon samples, 17α(H)-C30 diahopanes (C30*) are extensively distributed in the lacustrine hydrocarbon source rocks of the Yanchang Formation in Ordos Basin, but show remarkable differences in relative abundance among various source rocks. Generally, Chang 7 high-quality source rock (oil shale) developed in deep lake anoxic environment shows lower C30* content, whereas Chang 6-9 dark mudstone developed in shallow to semi-deep lake, sub-oxidizing environment shows relatively high to high C30* value. Particularly, Chang 7 and Chang 9 black mudstones in Zhidan region in the northeast of the lake basin show extremely high C30* value. A comparative analysis was made based on lithology, organic types and various geochemical parameters indicative of redox environment, and the results indicate that environmental factors such as redox settings and lithology are key factors that control the C30* relative abundance, while organic types and maturity may be minor factors. High to extremely high C30* values are indicative of sub-oxidizing environment of fresh-brackish water and shallow to semi-deep lake. Therefore, research on C30* relative content and distribution in lacustrine hydrocarbon source rocks in the Yanchang Formation, especially on the difference in C30* between Chang 7 high-quality source rocks (oil shale) and Chang 6-91 source rocks (dark mudstone), will provide an important approach for classification of Mesozoic lacustrine crudes and detailed oil-source correlation in the basin. | ZHANG WenZheng YANG Hua HOU LiHui LIU Fei | 2009 | Science China Earth Sciences2009，52，7： | 16 |
| 4 | Thick-skinned Contractional Salt Structures in the Kuqa Depression,the Northern Tarim Basin:Constraints from Physical Experiments显示文摘摘要:脸皮厚的 contractional 盐结构广泛地在西方的 Kuqa 消沉被开发,北 Tarim 盆。为了理解管理这些的发展的机制,组织,物理实验被进行,结果证明他们被地下室差错并且形成 paleo 高举和地下室斜坡的活动大部分管理。在这研究的模型材料是干燥的沙,矿脂和 plasticene (或难泡沫) ,分别地模仿 suprasalt,盐,和 subsalt 层。实验证明由于地下室差错并且形成 paleo 高举的活动,盐身体通常在被预先退出的边界差错抑制的 paleo 高举的中间的顶上显著地积累并且变厚。大规模戳差错和盐越过水坝落下的水的发展被地下室赞成与更大的剧降泼出。实验也断定因为盐层的存在,那微分结构的变丑能发生在 subsalt 和 suprasalt 层之间。他们的几何学和结构的高度的地点是不同的,尽管有高举的区域的大类似。穿透的盐挤入构造没在实验被观察,它显示弄短的 contractional 有效地不加速盐挤入构造的发展。 | YU Yixin TANG Liangjie YANG Wenjing JIN Wenzheng PENG Gengxin LEI Ganglin | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 15 |
| 5 | Research on failure scenarios of domes based on form vulnerability显示文摘In this paper, form vulnerability theory was applied to the analysis of the failure mechanisms of single-layer latticed spherical shells subjected to seismic excitations. Three 1/10 scale testing models were designed with characteristics as follows: Model 1 possesses overall uniform stiffness and is expected to collapse in the strength failure mode as some members become plastic; Model 2 possesses six man-made weak parts located on six radial main rib zones and is expected to collapse in the dynamic instability mode with all members still in the elastic stage; Model 3 strengthens the six weak zones of Model 2, and therefore, its stiffness is uniform. Model 3 is proposed to collapse in the strength failure mode when the members are still in the elastic stage. By increasing the peak ground accelerations of seismic waves gradually, the shaking table tests were carried out until all three models collapsed (or locally collapsed). On the basis of form vulnerability theory, topological hierarchy models of the test models were established through a clustering process, and various failure scenarios, including overall collapse scenarios and partial collapse scenarios, were identified by unzipping corresponding hierarchical models. By comparison of the failure scenarios based on theoretical analysis and experiments, it was found that vulnerability theory could effectively reflect the weakness zones in topological relations of the structures from the perspective of internal causes. The internal mechanisms of the distinct failure characteristics of reticulated shells subjected to seismic excitations were also revealed in this process. The well-formedness of structural clusters, Q, is closely related to the collapse modes, i.e., uniform changes of Q indicate a uniform distribution of overall structural stiffness, which indicates that strength failure is likely to happen; conversely, non-uniform changes of Q indicate that weak zones exist in the structure, and dynamic instability is likely to occur. | YE JiHong LIU WenZheng PAN Rui | 2011 | Science China(Technological Sciences)2011，54，11： | 15 |
| 6 | Multi-scale object detection by top-down and bottom-up feature pyramid network显示文摘While moving ahead with the object detection technology, especially deep neural networks, many related tasks, such as medical application and industrial automation, have achieved great success. However, the detection of objects with multiple aspect ratios and scales is still a key problem. This paper proposes a top-down and bottom-up feature pyramid network(TDBU-FPN),which combines multi-scale feature representation and anchor generation at multiple aspect ratios. First, in order to build the multi-scale feature map, this paper puts a number of fully convolutional layers after the backbone. Second, to link neighboring feature maps, top-down and bottom-up flows are adopted to introduce context information via top-down flow and supplement suboriginal information via bottom-up flow. The top-down flow refers to the deconvolution procedure, and the bottom-up flow refers to the pooling procedure. Third, the problem of adapting different object aspect ratios is tackled via many anchor shapes with different aspect ratios on each multi-scale feature map. The proposed method is evaluated on the pattern analysis, statistical modeling and computational learning visual object classes(PASCAL VOC)dataset and reaches an accuracy of 79%, which exhibits a 1.8% improvement with a detection speed of 23 fps. | ZHAO Baojun ZHAO Boya TANG Linbo WANG Wenzheng WU Chen | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 11 |
| 7 | Tectonic Evolution of the Middle Frontal Area of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘由分析平衡的生气的节和 Longmen 山戳带的沉淀历史,中国,我们断定它经历了五个构造阶段:(1 ) 形成阶段(T 3 x ) Longmen 的缩影,山,早 Indosinian 运动,和 Anxian 构造运动创造了 Longmen 山;(2 ) 稳定的构造阶段(更弱的构造运动导致了 Longmen 山戳带的 J 1) 稍微正在被高举并且稍微减退低岬盆;(3 ) 强烈构造阶段(J2.3 ) ,也就是早 Yanshan 运动;(4 ) 连续构造运动(K-E ) ,也就是迟了的 Yanshan 运动和早喜玛拉雅的运动;并且(5 ) Longmen 山(N-Q ) 的形成,也就是晚喜玛拉雅的运动。在那些构造变丑阶段期间, Anxian 运动和喜玛拉雅的运动在 Longmen 山的形成起了重要作用。喜玛拉雅的运动影响了 Longmen 山大多数;阶层强烈地推进了并且严重地被侵蚀。因为一些越过水坝落下的水被推,在 Longmen 山戳带的中间的部分有某 klippes 在以后向东南构造变丑。 | JIN Wenzheng TANG Liangjie YANG Keming WAN Guimei Lü Zhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 8 | Processing of array sonic logging data with nulti-scale STC technique显示文摘开发新信号处理技术是合乎需要的因为有效地在地上凿穿的强壮的干扰下面提取反映的波浪指导了波浪。我们为分离和反映的波浪的速度(缓慢) 分析介绍了一个多尺度的外表方法并且在地上凿穿指导了波浪声学的记载。它特殊为声学的思考调查与极端长的来源接收装置间距为最新发达的工具被设计。这个新方法是双树建筑群小浪变换(DT 享特威) 和缓慢旅行时间连贯(STC ) 的联合方法。应用程序到 3D 当模特儿的有限差别(FD ) 模仿了数据,到域数组,声音的波形信号表明了这个方法的能力适当地在从指导波浪的严重干扰下面提取反映的波浪并且在时间频率域压制噪音。 | Tao Guo He Fengjiang Yue Wenzheng Chen Ping | 2008 | Petroleum Science2008，5，3： | 9 |
| 9 | Epigenetics of epithelial Na^+ channel-dependent sodium uptake and blood pressure regulation显示文摘The epithelial Na+ channel(ENa C) consists of α,β,γsubunits.Its expression and function are regulated by aldosterone at multiple levels including transcription.ENa C plays a key role in Na+ homeostasis and blood pressure.Mutations in ENa C subunit genes result in hypertension or hypotension,depending on the nature of the mutations.Transcription of αENa C is considered as the rate-limiting step in the formation of functional ENa C.As an aldosterone target gene,αENa C is activated upon aldosterone-mineralocorticoid receptor binding to the cis-elements in the αENa C promoter,which is packed into chromatin.However,how aldosterone alters chromatin structure to induce changes in transcription is poorly understood.Studies by others and us suggest that Dot1a-Af9 complex represses αENa C by directly binding and regulating targeted histone H3 K79 hypermethylation at the specific subregions of αENa C promoter.Aldosterone decreases Dot1a-Af9 formation by impairing expression of Dot1 a and Af9 and by inducing Sgk1,which,in turn,phosphorylates Af9 at S435 to weaken Dot1a-Af9 interaction.MR attenuates Dot1aAf9 effect by competing with Dot1 a for binding Af9.Af17 relieves repression by interfering with Dot1a-Af9 interaction and promoting Dot1 a nuclear export.Af17-/-mice exhibit defects in ENa C expression,renal Na+ retention,and blood pressure control.This review gives a brief summary of these novel findings. | Wenzheng Zhang | 2015 | World Journal of Nephrology2015，4，3： | 7 |
| 10 | Geochemical characteristics and origin of gases from the Upper,Lower Paleozoic and the Mesozoic reservoirs in the Ordos Basin,China显示文摘The Ordos Basin,the second largest sedimentary basin in China,contains the broad distribution of natural gas types.So far,several giant gas fields have been discovered in the Upper and Lower Paleozoic in this basin,each having over 1000×10 8 m 3 of proven gas reserves,and several gas pools have also been discovered in the Mesozoic.This paper collected the data of natural gases and elucidated the geochemical characteristics of gases from different reservoirs,and then discussed their origin.For hydrocarbons preserved in the Upper Paleozoic,the elevatedδ13C values of methane,ethane and propane indicate that the gases would be mainly coal-formed gases;the singular reversal in the stable carbon isotopes of gaseous alkanes suggests the mixed gases from humic sources with different maturity.In the Lower Paleozoic,theδ13C 1 values are mostly similar with those in the Upper Paleozoic,but theδ13C 2 andδ13C 3 values are slightly lighter,suggesting that the gases would be mixing of coal-type gases as a main member and oil-type gases.There are multiple reversals in carbon isotopes for gaseous alkanes,especially abnormal reversal for methane and ethane(i.e.δ13C 1 >δ13C 2 ),inferring that gases would be mixed between high-mature coal-formed gases and oil-type gases.In the Mesozoic,the δ13Cvalues for gaseous alkanes are enriched in 12C,indicating that the gases are mainly derived from sapropelic sources;the carbon isotopic reversal for propane and butane in the Mesozoic is caused by microbial oxidation and mixing of gases from sapropelic sources with different maturity.In contrast to the Upper Paleozoic gases,the Mesozoic gases are characterized by heavier carbon isotopes of iso-butane than normal butane,which may be caused by gases generated from different kerogen types. Finally,according toδ13C 1 -Ro relationship and extremely low total organic carbon contents,the Low Paleozoic gases would not be generated from the Ordovician source as a main gas source,bycontrast, the Upper Paleozoic source as a main gas source is contributed to the Lower Paleozoic gases. | HU AnPing 1 ,Li Jian 2 ,ZHANG WenZheng 3 ,LI ZhiSheng 2 ,HOU Lu 4 &LIU QuanYou 5 1 Department of Earth Sciences,Zhejiang University,Hangzhou 310027,China 2 Langfang Branch,Reasearch Institute of Petroleum Exploration and Development,PetroChina,Langfang 065007,China 3 Institute of Exploration and Development,PetroChina Changqing Oilfield Company,Xi’an 710021,China 4 University of Petroleum,Beijing102249,China 5 PetroChina Research Institute of Petroleum Exploration and Development,Beijing 100083,China | 2008 | Science China Earth Sciences2008，51，S1： | 6 |
| 11 | Differential Tectonic Deformation of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘地调查和地震的节解释证明 Longmen 山戳带有明显的微分变丑:带状配列,分割和层化。带状配列意味着那,从 NW 到 NE, Longmen 山戳带能被划分成 Songpan-Garz ê构造的带,可锻的变丑带,基础深奥的戳带,正面的褶层戳带,和低岬消沉。它能向南向北被划分成五个片断从到的分割工具:北片断, Anxian 转移地区,中心片断, Guanxian 转移地区和南部的片断。层化意味着分开层在侧面划分结构的式样。在 Longmen 山戳带的分开层能被分类进三个范畴:深水平的分开层包括外壳披风系统分开层, intracrustal 分开层,和 Presinian 系统基础分开层;中间级的分开层包括寒武纪奥陶纪的分开层,志留纪分开层,等等;并且浅水平的分开层,包括的上面的三叠纪的 Xujiahe 形成分开层和侏罗记分开层。多水平分开层在塑造和 Longmen 山戳带的进化上有很重要的效果。 | TANG Liangjie YANG Keming JIN Wenzheng WAN Guimei LüZhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 6 |
| 12 | Three-dimensional conformal intensity-modulated radiation therapy of left femur foci does not damage the sciatic nerve显示文摘During radiotherapy to kill femoral hydatid tapeworms,the sciatic nerve surrounding the focus can be easily damaged by the treatment.Thus,it is very important to evaluate the effects of radiotherapy on the surrounding nervous tissue.In the present study,we used three-dimensional,conformal,intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani.The focus of the hydatid disease on the left femur was subjected to radiotherapy(40 Gy) for 14 days,and the right femur received sham irradiation.Hematoxylin-eosin staining,electron microscopy,and terminal deoxynucleotidyl transferase-d UTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal,with no obvious apoptosis after radiation.Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment.The mortality of the protoscolex was higher in the left side than in the right side.The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echinococcus granulosus was lower in the left femur than in the right femur.These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve. | Wanlong Xu Xibin Zhao Qing Wang Jungang Sun Jiangbo Xu Wenzheng Zhou Hao Wang Shigui Yan Hong Yuan | 2014 | Neural Regeneration Research2014，9，20： | 6 |
| 13 | Soil Heavy Metal Pollution and Health Risk Assessment of Abandoned Land in Coal Mining Areas in Xingren County显示文摘Total contents of heavy metals( Pb,Cr,Cd,Hg,As,Cu,Zn,and Ni) in 68 soil samples were determined to evaluate the contamination level of soil from five coal mine areas in Xingren County,Guizhou province.The pollution levels of heavy metals were characterized by anthropogenic influence multiple,and the pollution of heavy metal in soil was evaluated using geo-accumulation index.Based on the health risk models recommended by the U.S.Environmental Protection Agency( US EPA),the health risks of heavy metals in the soils were assessed.The results showed that the abandoned land in the five coal mining areas were contaminated by heavy metals,and the order of pollution levels of eight heavy metals was As>Pb>Cu>Hg>Ni>Cr>Cd>Zn.The soils suffered moderate-heavy pollution from As and Pb,and the contents of As and Pb in the soils were 13.16 and 4.76 times higher than the background values of Guizhou Province,followed by Cu,Hg and Ni,while soil pollution from Cr,Cd and Zn was mild.The order of non-carcinogenic risks of the heavy metals in the soils was As>Pb>Cr>Ni>Cu>Hg>Cd>Zn,and the non-carcinogenic risk value of As was higher than that its threshold value 1,which indicated that As had a high potential health risk to adults and children.The order of carcinogen risks of the four heavy metals was As>Cd>Cr>Ni,and the carcinogenic risk value of As was higher than its threshold value,indicating that As had a high carcinogenic risk to adults and children.The carcinogenic risk values of other three heavy metals(Cd,Cr and Ni)were lower than the threshold value,so they had no carcinogenic risk to human health.Moreover,children were more sensitively affected by heavy metals from the abandoned land.Therefore,the health of children in such areas should be paid more attention to.The HI value of the eight heavy metals to children was seven times higher than that to adults.The contribution rate of HQ_(Asto) HI was about 88%,and the contribution rate of CR_(As) to TCR was about 98%,so As was the most crucial factor influencing non-carcinogenic and carcinogenic risk in the abandoned soils. | Qin Fanxin Pang Wenpin Liu Wenzheng | 2015 | Meteorological and Environmental Research2015，6，11： | 6 |
| 14 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 15 | Origin and Accumulation of Natural Gases in the Upper Paleozoic Strata of the Ordos Basin in Central China显示文摘在 Ordos 盆的上面的古生代的阶层的天然气被气体的链烷的相对重的 C 同位素与δ
13 C 1和δ
13 C 2价值主要从 35 ‰ 到 30 ‰ 和 27 ‰ 到 22 ‰,分别地高δ
13在在有超过 0.95 的大多数 C 1/(C1-C5)比率的烃气体的乙烷和甲烷和占优势的甲烷之间的 C 旅行(回合 10 ),建议导出煤的气体的起源。气体展出为天然气的有那些的 C 1-C4 链烷的同位素的侧面发现了在的不同的碳更低这盆古生代,并且相信了从含碳二叠的煤措施被发源。地区性弥漫的煤气的累积的出现在中央盆的轻轻地向南方蘸的 Shanbei 斜坡是不同的。在各种各样的煤气的水库的气体的分子、同位素的作文变化与煤气的来源岩石的热成熟被联系,这被注意。丰富和 δ
13 甲烷的 C 价值通常向北并且从盆中心衰退到它的边缘,并且组合修正上的烃移植的效果似乎不足道。然而,在水库的垂直、侧面的节的单性生植方解石的 C 同位素显示出一个常规变化,并且总体上向上并且向盆边缘被弄空。有煤气的成熟坡度的联合,分析能被认为是为煤气的移植的一个有用工具。 | ZHU Yangming WANG Jibao LIU Xinse ZHANG Wenzheng | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 5 |
| 16 | Comparative Proteomic Analysis of Arabidopsis Mature Pollen and Germinated Pollen显示文摘Proteomic analysis was applied to generating the map of Arabidopsis mature pollen proteins and analyzing the differentially expressed proteins that are potentially involved in the regulation of Arabidopsis pollen germination.By applying 2-D electrophoresis and silver staining,we resolved 499 and 494 protein spots from protein samples extracted from pollen grains and pollen tubes,respectively.Using the matrix-assisted laser desorption ionization time-of-flight mass spectrometry method,we identified 189 distinct proteins from 213 protein spots expressed in mature pollen or pollen tubes,and 75 new identified proteins that had not been reported before in research into the Arabidopsis pollen proteome.Comparative analysis revealed that 40 protein spots exhibit reproducible significant changes between mature pollen and pollen tubes.And 21 proteins from 17 downregulated and six upregulated protein spots were identified.Functional category analysis indicated that these differentially expressed proteins mainly involved in signaling,cellular structure,transport,defense/stress responses,transcription,metabolism,and energy production.The patterns of changes at protein level suggested the important roles for energy metabolism-related proteins in pollen tube growth,accompanied by the activation of the stress response pathway and modifications to the cell wall. | Junjie Zou Lianfen Song Wenzheng Zhang Yi Wang Songlin Ruan Wei-Hua Wu | 2009 | Journal of Integrative Plant Biology2009，51，5： | 5 |
| 17 | Main Structural Styles and Deformation Mechanisms in the Northern Sichuan Basin,Southern China显示文摘摘要:三叠纪的 Jialingjiang 形成和 Leikoupo 形成被厚盐层描绘。三个 tectono-stratigraphic 序列能在北四川盆根据降低中间的三叠纪的盐床的分开层被识别,即亚盐顺序 Sinian 创作了到更低的三叠纪的 Feixianguan 形成,更低的三叠纪的 Jialingjiang 形成的盐顺序和中间三叠纪的 Leikoupou 形成,并且在上盐顺序上面三叠纪的 Xujiahe 形成,侏罗记和白垩纪的大陆人 clastics 创作了。一系列特定的结构的式样例如包含地下室的使成鳞状的戳带的强烈地使变形的带,包含地下室、分开盐的附加的使变形的带,埋葬的盐相关的分开的带,双,堆三角地区和弹出式,在北四川盆发展了。相对薄的盐床,与北四川盆的结构的变丑联系了,可能充当大 decollement 层。在北四川盆的变丑机制包括了地区性的压缩和弄短的、塑料流动和分开,构造 upwelling 和侵蚀,重力的滑动并且传播。在北四川盆的来源岩石是位于盐层下面的阶层,例如寒武纪,志留纪并且二叠。与三叠纪的盐有关的结构的变丑为烃控制了陷井的式样。在北四川盆的烃陷井的形成和发展可能有一在对烃累积和保藏有利的降低中间的三叠纪的盐序列之上适用。盐层在降低中间三叠纪形成了主要帽子摇并且为烃的累积和保藏是有利的。 | TANG Liangjie GUO Tonglou JIN Wenzheng YU Yixin LI Rufeng | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 5 |
| 18 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 19 | Design and experiment of anti-vibrating and anti-wrapping rotary components for subsoiler cum rotary tiller显示文摘The commonly used subsoiling cum rotary tiller machine(SRT)in Northern China is a combination of subsoiler and horizontal rotary tiller,however backfilling of the subsoiling slot,excessive vibration and plant residue wrapping on rotary components has been rarely considered.Therefore,the rotary components and assembly were redesigned to address these issues and to an SRT fitted with IT225 short curve rotary blades behind the V-shape subsoiling slots and IIT245 long curve rotary blades between the tines.Long and short blades were fitted on a rotor in a double helix,with optimal spiral angles of 65° and 90°,and phase angle of 147°and 180°,respectively.Compared with the commonly used SRT(CSRT),the additional anti-wrapping cutting blades in the circumferential and axial direction of ASRT could remove hanging residue on the blade holders,wrapping on the rotor and formation of an isolation layer.Moreover,the cutting edge curve of anti-wrapping cutting blades was an exponential curve.Field tests demonstrated that the redesigned SRT with anti-vibrating and anti-wrapping rotary components(ASRT)had was a significant advancement over the CSRT.Moreover,the working depth of rotary tillage was more stable,while other observations confirmed that backfilling of the subsoiling slot was also improved. | Kan Zheng Allen D.McHugh Hongwen Li Qingjie Wang Caiyun Lu Hongnan Hu Wenzheng Liu Zhiqiang Zhang Peng Liu Jin He | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
| 20 | On the development mechanism of the lacustrine high-grade hydrocarbon source rocks of Chang 91 member in Ordos Basin显示文摘As revealed from recent drilling and organic geochemical testing and research, a series of lacustrine high-grade hydrocarbon source rocks was discovered in the upper section of the Chang 9 oil reservoir member of upper Triassic in Ordos Basin. The hydrocarbon source rocks show average TOC content as high as 5.03%, average bitumen 'A' content as high as 0.8603%, and good quality organic precursors, which are of the sapropelic type mainly derived from lower aquatic plants and have reached the thermal evolution stage featured by oil-producing climax. Generally the lacustrine high-grade hydrocarbon source rocks were developed in local depressions of a lake basin, and the Chang 91 member was particularly formed in a depositional environment characterized by fresh water to weakly saline water, weakly oxidizing to weakly reducing setting and semi-deep lake facies, as was demonstrated by a variety of organic to inorganic geochemical parameters. As a result, high productivity constitutes the principal controlling force for generation of this series of high-grade hydrocarbon source rocks. Deposition of thinly-bedded and laminated tuffs as well as positive Eu anomaly corroborate the possible occurrence of anoxic geological event closely related to contemporaneous volcanic eruption, which would play a key part in development of the Chang 91 member of high-grade hydrocarbon source rocks. | ZHANG WenZheng YANG Hua FU SuoTang ZAN ChuanLi | 2007 | Science China Earth Sciences2007，50，z2： | 4 |
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