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| 1 | Microarray-Assisted Fine-Mapping of Quantitative Trait Loci for Cold Tolerance in Rice显示文摘包括冷压力抵抗,许多重要农学的特点由量的特点 loci (QTL ) 复杂、控制。这些 QTL 的隔离将极大地有益于农业工业,但是它是一项挑战性的任务。这研究由把 microarray 与印射 QTL 相结合以便在早幼苗的舞台从寒冷容忍的变化 IL112 识别寒冷容忍的 QTL 探索了综合策略。IL112 的所有早幼苗在 45 点为 9 d 通常幸存吗?? | Fengxia Liu Wenying Xu Qian Song Lubin Tan Jiayong Liu Zuofeng zhu Yongcai Fu Zhen Su Chuanqing Sun | 2013 | Molecular Plant2013，6，3： | 17 |
| 2 | Comparison of sentinel lymph node detection performances using blue dye in conjunction with indocyanine green or radioisotope in breast cancer patients: a prospective singlecenter randomized study显示文摘Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice. | Long Yuan Xiaowei Qi Yi Zhang Xinhua Yang Fan Zhang Linjun Fan Li Chen Kongyong Zhang Ling Zhong Yanling Li Sijie Gan Wenying Fu Jun Jiang | 2018 | Cancer Biology & Medicine2018，15，4： | 9 |
| 3 | Spatial Restructuring of Industries Under Economic Globalization: Enterprises’ Choice and Governments’ Response | LI Xun, Professor, Department of Urban and Regional Planning, Geography and Planning School, Sun Yat-sen University Deputy Director, Planning and Design Institute of Sun Yat-sen University Center for Studies of Hong Kong, Macao and Pearl River Delta, Sun Yat-sen University, Guangzhou, P. R. China. FU Wenying, Department of Urban and Regional Planning, Geography and Planning School, Sun Yat-sen University, Guangzhou, P. R. China. LIU Hongfeng, Department of Urban and Regional Planning, Geography and Planning School, Sun Yat-sen University, Guangzhou, P. R. China. | 2009 | China City Planning Review2009，18，2： | 8 |
| 4 | Efficient induction of a Her2-specific anti-tumor response by dendritic cells pulsed with a Hsp70L1–Her2_(341–456) fusion protein显示文摘Heat shock proteins(HSPs)have been shown to interact with antigen-presenting cells(APCs),especially dendritic cells(DCs).HSPs act as potent adjuvants,inducing a Th1 response,as well as antigen-specific CD8^(+) cytotoxic T lymphocytes(CTL)via cross-presentation.Our previous work has demonstrated that Hsp70-like protein 1(Hsp70L1),a new member of the Hsp70 subfamily,can act as a powerful Th1 adjuvant in a DC-based vaccine.Here we report the efficient induction of tumor antigen-specific T cell immune response by DCs pulsed with recombinant fusion protein of Hsp70L1 and Her2_(341–456),the latter of which is a fragment of Her2/neu(Her2)containing E75(a HLA-A2 restricted CTL epitope).The fusion protein Hsp70L1–Her2_(341–456) promotes the maturation of DCs and activates them to produce cytokines,such as IL-12 and TNF-a,and chemokines,such as MIP-1a,MIP-1b and RANTES.Taken together,these results indicate that the adjuvant activity of Hsp70L1 is maintained in the fusion protein.Her2-specific HLA-A2.1-restricted CD8^(+) CTLs can be generated efficiently either from the Peripheral blood lymphocytes(PBL)of healthy donors or from the splenocytes of immunized HLA-A2.1/K^(b) transgenic mice by in vitro stimulation or immunization with DCs pulsed with the Hsp70L1–Her2_(341–456) fusion protein.This results in more potent target cell killing in an antigen-specific and HLA-A2.1-restricted manner.Adoptive transfer of splenocytes from transgenic mice immunized with Hsp70L1–Her2_(341–456)-pulsed DCs can markedly inhibit tumor growth and prolong the survival of nude mice with Her2^(+)/HLA-A2.1^(+) human carcinomas.These results suggest that Hsp70L1–Her2_(341–456)-pulsed DCs could be a new therapeutic vaccine for patients with Her2^(+) cancer. | Qiang Fu Yanfeng Wu Fang Yan Ning Wang Wenying Wang Xuetao Cao Yajie Wang Tao Wan | 2011 | Cellular & Molecular Immunology2011，8，5： | 3 |
| 5 | Analysis of adverse events following the treatment of autologous cytokine-induced killer cells for adoptive immunotherapy in malignant tumour sufferers显示文摘 | Yajing Zhang Lei Xia Yan Zhang Yao Wang Xuechun Lu Fengxia Shi Yang Liu Meixia Chen Kaixhao Feng Wenying Zhang Xiaobing Fu Weidong Han | 2015 | Expert Opinion on Biological Therapy2015，，： | 1 |
| 6 | The immunostimulatory effects of hot-water extract of Gelidium amansii via immersion,injection and dietary administrations on white shrimp Litopenaeus vannamei and its resistace against Vibrio alginolvticus 显示文摘 | FU Yuwin HOU Wenying YEH Sutuen | 2007 | Fish Shellfish Immunology2007，22，： | 1 |
| 7 | Effect of dietary supplementation with Bacillus subtilis on the growth, per- formance, immune response and antioxidant activities of the shrimp (Litopenaeus vannamei) 显示文摘 | Shen Wenying Fu Linglin Li Weifen | 2011 | Aqu Res2011，41，： | 1 |
| 8 | Energy Paths that Sustain the Warm-Sector Torrential Rainfall over South China and Their Contrasts to the Frontal Rainfall: A Case Study显示文摘Predicting warm-sector torrential rainfall over South China,which is famous for its destructive power,is one of the most challenging issues of the current numerical forecast field.Insufficient understanding of the key mechanisms underlying this type of event is the root cause.Since understanding the energetics is crucial to understanding the evolutions of various types of weather systems,a general methodology for investigating energetics of torrential rainfall is provided in this study.By applying this methodology to a persistent torrential rainfall event which had concurrent frontal and warm-sector precipitation,the first physical image on the energetics of the warm-sector torrential rainfall is established.This clarifies the energy sources for producing the warm-sector rainfall during this event.For the first time,fundamental similarities and differences between the warm-sector and frontal torrential rainfall are shown in terms of energetics.It is found that these two types of rainfall mainly differed from each other in the lower-tropospheric dynamical features,and their key differences lay in energy sources.Scale interactions(mainly through downscale energy cascade and transport)were a dominant factor for the warm-sector torrential rainfall during this event,whereas,for the frontal torrential rainfall,they were only of secondary importance.Three typical signals in the background environment are found to have supplied energy to the warm-sector torrential rainfall,with the quasi-biweekly oscillation having contributed the most. | Shenming FU Jingping ZHANG Yali LUO Wenying YANG Jianhua SUN | 2022 | Advances in Atmospheric Sciences2022，39，9： | 1 |
| 9 | A Thorough Evaluation of the Passive Microwave Radiometer Measurements onboard Three Fengyun-3 Satellites显示文摘Microwave Radiometer Imager(MWRI) is a key payload of China’s second generation polar meteorological satellite, i.e., Fengyun-3 series(FY-3). Up to now, 5 satellites including FY-3A(2008), FY-3B(2010), FY-3C(2013), FY-3D(2018), and FY-3E(2021) have been launched successfully to provide multiwavelength, all-weather, and global data for decades. Much progress has been made on the calibration of MWRI and a recalibrated MWRI brightness temperature(BT) product(V2) was recently released. This study thoroughly evaluates the accuracy of this new product from FY-3B, 3C, and 3D by using the simultaneous collocated Global Precipitation Measurement(GPM)Microwave Imager(GMI) measurements as a reference. The results show that the mean biases(MBEs) of the BT between MWRI and GMI are generally less than 0.5 K and the root mean squares(RMSs) between them are less than1.5 K. The previous notable ascending and descending difference of the MWRI has disappeared. This indicates that the new MWRI recalibration procedure is very effective in removing potential errors associated with the emission of the hot-load reflector. Analysis of the dependence of MBE on the latitude and earth scene temperature shows that MBE decreases with decreasing latitude over ocean. Furthermore, MBE over ocean decreases linearly with increasing scene temperature for almost all channels, whereas this does not occur over land. A linear regression fitting is then used to modify MWRI, which can reduce the MBE over ocean to be within 0.2 K. The standard deviation of error of GMI, FY-3B, and FY-3D MWRI BT data derived by using the three-cornered hat method(TCH) shows that GMI has the best overall performance over ocean except at 10.65 GHz where its standard deviation of error is slightly larger than that of FY-3D. Over land, the standard deviation of error of FY-3D is the lowest at almost all channels except at 89V. MWRI onboard FY-3 series satellites would serve as an important passive microwave radiometer member of the constellation to monitor key surface and atmospheric properties. | Xinran XIA Wenying HE Shengli WU Disong FU Wei SHAO Peng ZHANG Xiangao XIA | 2023 | Journal of Meteorological Research2023，37，4： | 0 |
| 10 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
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