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| 1 | High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D显示文摘Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal surgery.However,they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 weeks.Afterward,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and histology.Titanium(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd.Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue.The results were correlated to in vitro data obtained from the same material and shape.The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK.The results suggest that both Mg-xGd alloys are suitable as materials for bone implants. | Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer | 2022 | Bioactive Materials2022，7，7： | 2 |
| 2 | Rho and Rac take center stage显示文摘 | Burridge K Wennerberg K | 2004 | Cell2004，116，2： | 1 |
| 3 | The Ras superfamily at a glance显示文摘 | Wennerberg K Rossman KL Der CJ | 2005 | J Cell Sci2005，118，5： | 1 |
| 4 | Rho and Rac take center stage 显示文摘 | Burridge K Wennerberg K | 2004 | Cell2004，116，2： | 1 |
| 5 | Rho and Rac take center stage显示文摘 | Burridge K Wennerberg K | 2004 | Cell2004，116，： | 1 |
| 6 | Rho and Rac take center stage 显示文摘 | Burridge K Wennerberg K | 2004 | Cell2004，116，2： | 1 |
| 7 | Rho and Rac take center stage 显示文摘 | Burridge K Wennerberg K | 2004 | Ce112004，116，2： | 1 |
| 8 | Integrin signaling to the actin cytoskeleton显示文摘 | DeMali K A Wennerberg K Burridge K | 2003 | Curr Opin Cell Biol2003，15，5： | 1 |
| 9 | A quantitative comparison of machined commercially pure titanium and titanium-alconinum-vandadium implants in rabbit bone显示文摘 | Johansson CB Han CH Wennerberg A | 1998 | Int J Oral Maxiuofac Implants1998，13，： | 1 |
| 10 | Highly Efficient Cu ( In, Ga) Se2 Mini-Modules 显示文摘 | KESSLER J WENNERBERG J BODEGARD M | 2003 | Solar Energy Materials & Solar Ceils2003，75，12： | 1 |
| 11 | Suggested guidelines for the topographic evaluation of implant surfaces 显示文摘 | Wennerberg A Albrektsson T | 2000 | Int J Oral Maxillofac Implants2000，15，3： | 1 |
| 12 | Oral implant surfaces:Part 1-review focusing on topographic and chemical properties of different surfaces and in vivo responses to them显示文摘 | Albrektsson T Wennerberg A | | 0，，05： | 1 |
| 13 | Determining optimal surface roughness of Ti02 blasted titanium implant material for attachment, proliferation and differentiation of cells derived from human mandibular alveolar bone 显示文摘 | Mustafa K Wennerberg A Wroblewski J | 2001 | Clin Oral Implants Res2001，12，5： | 1 |
| 14 | Polymerization of type Ⅰ and Ⅲ collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1 显示文摘 | Veiling T Risteli J Wennerberg K | 2002 | J Biol Chem2002，277，37： | 1 |
| 15 | Rho and Rac take center stage显示文摘 | Burridge K Wennerberg K | 2004 | Cell2004，116，2： | 1 |
| 16 | Oral implant surfaces:Part 2-review focusing on clinical knowledge of different surfaces显示文摘 | Albrektsson T Wennerberg A | 2004 | Int J Prosthodont2004，17，5： | 1 |
| 17 | Integrin signalingto the actin cytoskeleton 显示文摘 | DeMali KA Wennerberg K Burridge K | 2003 | Curr Opin Cell Biol2003，15，5： | 1 |
| 18 | Oral implant surfaces:part 2-review focusing on clinical knowledge of different surfaces显示文摘 | Albrektsson T Wennerberg A | 2004 | Int J Prosthodont2004，17，5： | 1 |
| 19 | Thin film PV modules for low-concentrating systems显示文摘 | Johan Wennerberg John Kessler Jonas Hedstrom | 2001 | Solar Energy2001，69，6： | 1 |
| 20 | SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis 显示文摘 | Ellerbroek SM Wennerberg K Arthur WE | 2004 | Mol Biol Cell2004，15，7： | 1 |
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