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| 1 | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding显示文摘在 2002-2003 的 SARS 的全球爆发被新人的 coronavirus SARS-CoV 的感染引起。SARS-CoV 的感染主要通过病毒的表面 glycoproteins 被调停,它由 S1 和 S2 子单元组成并且在 virions 的信封上形成更整齐的尖铁。这里,我们报导处于单个粒子的 cryo 电子显微镜学决定的不同 conformational 状态更整齐的 SARS-CoV 表面尖铁的 ectodomain 结构。1 在 4.3 点决定了的符合构造?分辨率是三方面的对称并且有所有三受体绑定 C 终端域 1 (CTD1s ) S1 子单元在在位置下面。绑定下面到 SARS-CoV 受体 ACE2 的 CTD1s 不由于位的碰撞是可能的,建议 1 代表的符合构造受体绑定不活跃的状态。在 7.3, 5.7 和 6.8 点坚定的符合构造 2-4?决定都是不对称的,在哪个 RBD 旋转离开下面由不同角度到的位置一起来位置。起来 CTD1 为 ACE2 约会暴露受体绑定地点,建议符合构造 2-4 代表受体绑定活跃状态。这个 conformational 变化也为抵销指向 CTD1 的抗体的 SARS-CoV 的绑定被要求。这现象能被扩大到为受体绑定利用 S1 子单元的 CTD1 的另外的 betacoronaviruses,它提供新卓见进在感染期间更整齐的 coronavirus 熔化前尖铁的中间的状态。 | Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang XinquanWang | 2017 | Cell Research2017，27，1： | 25 |
| 2 | Analysis of ionospheric anomalies before the 2011 M_w 9.0 Japan earthquake显示文摘On March 11, 2011, a large earthquake of Mw=9.0 occurred near the east coast of Honshu, Japan. This paper investigates preearthquake ionospheric anomalies during the earthquake period, using data from global navigation satellite systems and ionosonde stations near the epicenter. A clear anomaly that occurred on March 8 lasted 6 hours. Eliminating ionospheric anomalies that may have been caused by solar activities and magnetic storms, we believe that a positive anomaly on March 8 was very possibly an ionospheric precursor. The affected ionospheric area on March 8, which is evident on a vertical total electron content distribution map, extended to 50° in longitude and 20° in latitude, with length ratio approximately 3:1. The anomaly peak arose from 15:00-19:00 LT, and its location did not coincide with the vertical projection of the epicenter, but was instead to its south. Corresponding ionospheric anomalies are also observed in the magnetically conjugated region. There were no obvious ionospheric anomalies in other parts of the world. To analyze changes in the ionospheric anomaly, computerized ionospheric tomography technology was used to invert the spatial and temporal distribution of electron density in the ionosphere. The ionospheric anomaly on March 8, 2011 is suggested to be an ionospheric precursor of the March 11 earthquake in Japan. | YAO YiBin CHEN Peng WU Han ZHANG Shun PENG WenFei | 2012 | Chinese Science Bulletin2012，57，5： | 14 |
| 3 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 4 | Effect of electrically stimulating acupoint, Zusanli(ST 36), on patient’s recovery after laparoscopic colorectal cancer resection: a randomized controlled trial显示文摘OBJECTIVE:To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic colorectal cancer resection and its clinical significance.METHODS:Sixty-four patients undergoing laparoscopic colorectal resection were randomly divided into two groups,the control group (group A) and the TEAS group (group B).Patients in the TEAS group received electroacupuncture stimulation of bilateral Zusanli (ST 36) at 30 min before anesthesia to the end of surgery.The patients in the control group were not given the stimulation.Perioperative anesthesia management of the two groups were performed according to the ERAS guidelines,and postoperative patient-controlled intravenous analgesia (PCIA) was used.The amount of remifentanil used in the two groups was observed and recorded,and the visual analogue scale (VAS) of the 4,12,24 and 48 h after surgery in the two groups was recorded.Moreover,postoperative anal exhaust time,postoperative feeding time,postoperative first ambulation time and postoperative hospital stay length were compared between the two groups.RESULTS:Compared with group A,the VAS score of group B decreased significantly at 48 h after operation (P < 0.05).The postoperative anal exhaust time in group B was significantly shorter than that of group A (P < 0.05).There was no significant difference between the two groups with regards to remifentanil consumption,postoperative feeding time,postoperative first ambulation time and postoperative hospital stay (all P > 0.05).CONCLUSION:TEAS can promote the recovery of postoperative gastrointestinal function and reduce the pain intensity 48 h after surgery,thus satisfying the need of early postoperative analgesia. | Huang Wei Yu Tingyu Long Wenfei Xiao Jianbin Zhao Gaofeng | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 14 |
| 5 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 6 | Convergence of multi-block Bregman ADMM for nonconvex composite problems显示文摘The alternating direction method with multipliers(ADMM) is one of the most powerful and successful methods for solving various composite problems. The convergence of the conventional ADMM(i.e.,2-block) for convex objective functions has been stated for a long time, and its convergence for nonconvex objective functions has, however, been established very recently. The multi-block ADMM, a natural extension of ADMM, is a widely used scheme and has also been found very useful in solving various nonconvex optimization problems. It is thus expected to establish the convergence of the multi-block ADMM under nonconvex frameworks. In this paper, we first justify the convergence of 3-block Bregman ADMM. We next extend these results to the N-block case(N≥3), which underlines the feasibility of multi-block ADMM applications in nonconvex settings. Finally, we present a simulation study and a real-world application to support the correctness of the obtained theoretical assertions. | Fenghui WANG Wenfei CAO Zongben XU | 2018 | Science China(Information Sciences)2018，61，12： | 9 |
| 7 | An improved reduced-rank STAP interference suppression method in design of GNSS receivers显示文摘In this paper,we address the problem of interference cancellation in global positioning system(GPS) receiver using an adaptive reduced-rank space-time adaptive processing(STAP) interference suppression method based on multistage nested Wiener filter(MSNWF).This improved adaptive reduced-rank method is based on the improved Gerschgorin radii algorithm.First,the cross-correlations between the desired signals of the adjacent stages of MSNWF are directly used to calculate the Gerschgorin radii instead of employing the eigenvalue decomposition of the covariance matrix.Then,a heuristic decision rule based on Gerschgorin disk estimator(GDE) is employed to estimate the rank of interference subspace.Thus optimal rank can be adaptively selected without increasing the computation.Analysis and results of the experiment show that the proposed method further reduces the computation of STAP and enhances its real-time property with the interference suppression performance unaffected. | GONG WenFei SUN Xin | 2012 | Science China(Information Sciences)2012，55，10： | 8 |
| 8 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 9 | Religion and stock price crash risk:Evidence from China显示文摘This paper investigates whether religious traditions influence firm-specific crash risk in China.Using a sample of A-share listed firms from 2003 to 2013,we provide evidence that the more intense the religious environment,the lower the stock price crash risk,implying that religion plays an important role in Chinese corporate governance.Further,we find that(1) religion affects stock price crash risk by reducing earnings management and the management perk problem;(2) different religions have different effects,and Taoism,in particular,is unrelated to crash risk; and(3) the effects of religion are more pronounced with higher quality corporate governance and a stronger legal environment.Religion constrains the management agency problem,thus reducing stock price crash risk in China.Our paper enriches the literature on stock price crash risk and religion,and on new economic geography. | Wenfei Li Guilong Cai | 2016 | China Journal of Accounting Research2016，，3： | 7 |
| 10 | Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival显示文摘哺乳动物的胰腺的房间通过胰岛素的生产和分泌物在开发和葡萄糖动态平衡起一个枢轴的作用。在房间数字的功能的失败或减少导致类型 2 糖尿病(T2D ) 。尽管有 -cells, 的生理的重要性,房间的生存能力经常主要由于它适应他们的变化微型环境的差的能力被质问。否定地影响房间生存能力的因素之一是象 palmitate 那样的免费的丰满的酸(船边交货) 的高集中。在这个工作,我们证明当房间与 palmitate 被对待时,那联系是的蛋白质(Yap1 ) 被激活。我们用啮齿类动物 insulinoma 房间线的 loss-of-function 和 gain-of-function 分析表明没有调整他们的增长, Yap1 在房间压制导致 palmitate 的 apoptosis。我们也发现在 palmitate 处理之上, F 肌动朊的重新整理调停 Yap1 激活。Yap1 目标基因之一的 Palmitate 处理增加表示,结缔组织生长因素(CTGF ) 。我们有 CTGF 的 gain-of-function 分析建议 CTGF 可以是在对导致船边交货的 apoptosis 的保护的机制的 Yap1 的下游的因素。 | Yaoting Deng Yurika Matsui Wenfei Pan Qiu Li Zhi-Chun Lai | 2016 | Protein & Cell2016，7，5： | 7 |
| 11 | Physical activity among older Chinese adults living in urban and rural areas: A review显示文摘With an increase in rural-to-urban migration, a rapidly aging population, and the rising risk of developing noncommunicable diseases in China,it is important to understand the epidemiology of physical activity(PA) and health in the context of disease prevention and population health.Despite its public health importance, there is a significant lack of knowledge about PA in older Chinese adults that may hamper primary prevention efforts of health promotion in an increasingly aging population. To fill this gap, this article presents a narrative review of PA in the older Chinese adult population with a special focus on residential settings(i.e., urban and rural). Using existing studies, the review examines overall PA patterns and their correlates and discusses public health implications and future research. Although there are some preliminary indications of urban and rural differences in PA in the aging population in China, continued research efforts are needed to facilitate primary prevention efforts aimed at reducing noncommunicable diseases and promoting an active lifestyle among the largest population of older people in the world. | Wenfei Zhu Aiping Chi Yuliang Sun | 2016 | Journal of Sport and Health Science2016，5，3： | 6 |
| 12 | Tracking method based on separation and combination of the measurements for radar and IR fusion system显示文摘A new distributed fusion method of radar/infrared (IR) tracking system based on separation and combination of the measurements is proposed by analyzing the influence of rate measurement. The rate information separated from the radar measurements together with measurements of IR form a pseudo vector of IR, and the corresponding filter is designed. The results indicate that the method not only makes a great improvement to the local tracker’s performance, but also improves the global tracking precision efficiently. | Wang Qingchao Wang Wenfei | 2009 | Journal of Systems Engineering and Electronics2009，20，2： | 5 |
| 13 | Efficient improvement of 2.7 μm luminescence of Er^(3+):oxyfluoride glass containing gallium by Yb^(3+) ions codoping显示文摘Mid-infrared laser materials with low phonon energy have significant applications. However, the development of available glass systems for high-power laser gain medium have posed a great challenge.Therefore, we investigated the 2.7 μm spectroscopic properties of Er^(3+)/Yb^(3+) -codoped oxyfluoride glass containing gallium, which were prepared by typically melting and quenching methods. The 2.7 μm luminescence properties of the Er^(3+)/Yb^(3+)-codoped oxyfluoride glass containing gallium were recorded by a 980 nm laser diode. The Judde Ofelt parameters, decay curves, emission cross section, energy transfer efficiency and quantum efficiency were calculated. The maximum emission cross section of YbFGa-0.5 is 1.63 × 10^(-20) cm^2 by 980 nm excitation. The energy transfer efficiency is calculated to be77.8% for the YbFGa-0.5 glass around 2700 nm. The quantum efficiency at 1530 nm is 65.6%. The result reveals that the best doping concentration ratio of Er^(3+):Yb^(3+) ions is 1:0.5, and suggests an effective energy transfer from Yb^(3+) to Er^(3+) ions. | Yapei Peng Xinqiang Yuan Long Zhang Peiguang Yan Wenfei Zhang Shuangchen Ruan | 2019 | Journal of Rare Earths2019，37，5： | 5 |
| 14 | Classification and comparison of physical and chemical properties of corn stalk from three regions in China显示文摘Corn stalk samples from Anhui,Jiangxi and Shanghai were used as test materials.Their physical,chemical and thermo-chemical engineering characteristics were analyzed.The similarities and differences in properties of corn stalk from the three regions were determined using SIMCA-P and SPSS software in order to obtain a proper energy utilization method of corn stalk.The results show that the corn stalk from Shanghai has significant differences from the samples of Jiangxi and Anhui.In particular,the following properties of corn stalk from Shanghai such as the contents of cellulose,calcium(Ca),iron(Fe),crude ash,volatile matter,carbon(C),nitrogen(N),and oxygen(O)are significantly different from those of Jiangxi and Anhui samples(P<0.05).While other properties such as the contents of magnesium(Mg),copper(Cu),zinc(Zn),moisture,hydrogen(H),and sulfur(S)have no significant difference among samples of three regions.Compared with the corn stalk in Anhui and Jiangxi,the Shanghai samples are more suitable for the production of ethanol because of their higher ratio of cellulose to hemi-cellulose content.Because of its high content of ash and low calorific value,the Shanghai corn stalk is suitable for the gasification process instead of for direct combustion or bio-oil production.The research can provide a reference for raw material selection for biomass energy production and utilization. | Wang Lu Liu Ronghou Sun Chen Cai Wenfei Tao Yiwei Yin Renzhan Mei Yuanfei | 2014 | International Journal of Agricultural and Biological Engineering2014，7，6： | 5 |
| 15 | Comments to “Mechanism of hamstring muscle strain injury in sprinting”by Yu et al.显示文摘We have carefully read Dr.Yu and his colleagues'~1review on the mechanism of hamstring muscle strain injury in sprinting.There is no doubt that they have done a lot work in this field.Their views are based on 3 pieces of evidence.First,observations from in situ animal models suggest that muscle strain injuries are highly associated with eccentric contractions.Second,the magnitude of muscle strain,rather than the force。 | Yu Liu Yuliang Sun Wenfei Zhu Jiabin Yu | 2017 | Journal of Sport and Health Science2017，6，2： | 5 |
| 16 | Zonal method solution of radiative heat transfer in a one-dimensional long roller-hearth furnace in CSP显示文摘A radiative heat transfer mathematical model for a one-dimensional long furnace was set up in a through-type roller-hearth furnace (TTRHF) in compact strip production (CSP). To accurately predict the heat exchange in the furnace, modeling of the complex gas energy-balance equation in volume zones was considered, and the heat transfer model of heating slabs and wall lines was coupled with the radiative heat transfer model to identify the surface zonal temperature. With numerical simulation, the temperature fields of gas, slabs, and wall lines in the furnace under one typical working condition were carefully accounted and analyzed. The fundamental theory for analyzing the thermal process in TTRHF was provided. | Wenfei Wu Yanhui Feng Xinxin Zhang | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 4 |
| 17 | Integration of nanoscale light emitters:an efficient ultraviolet and blue random lasing from NaYF_4:Yb/Tm hexagonal nanocrystals显示文摘Near infrared light-controlled release of payloads from ultraviolet-sensitive(UV-sensitive) polymer hydrogels or nanocarriers is one of the most promising strategies for biotherapy. Here, we propose the concept of light activation of NaYF_4:20%Yb, 2%Tm nanocrystals(NCs). NaYF_4:20%Yb, 2%Tm NCs are synthesized by a solvothermal method. Effective upconversion luminescence from NaYF_4:20%Yb, 2%Tm NCs excited by a continuous wave(CW) 980 nm laser is obtained. The NaYF_4:20%Yb, 2%Tm NCs are then used as a laser gain medium and sandwiched between Al and quartz reflectors to form laser microcavities. UV and blue upconverted random lasing is obtained from the laser microcavities. Hence, we verify explicitly that the NaYF_4:Yb, Tm NCs support UV and blue upconversion random lasing via a 980 nm nanosecond laser excitation. Our work provides what we believe is a new concept for precision and localized cancer therapy by external light excitation. | YA-PEI PENG WEI LU PENGPENG REN YIQUN NI YUNFENG WANG LONG ZHANG YU-JIA ZENG WENFEI ZHANG SHUANGCHEN RUAN | 2018 | Photonics Research2018，6，10： | 4 |
| 18 | Label-free Detection of Biotin Using Nanoporous TiO2/DNA Thin-film Coated Wavelength Interrogated Surface Plasmon Resonance Sensors显示文摘 | LI Qiushun HE Hao WANG Junnan ZHENG Hui SHI Jianguo LI Mingyu DONG Wenfei QI Zhimei | 2014 | Chemical Research in Chinese Universities2014，30，1： | 4 |
| 19 | Review of regional carbon counting methods for the Chinese major ecological engineering programs显示文摘In order to improve environment and relieve poverty, China has launched a series of major ecological engineering programs since the 1980 s. These include the Natural Forest Conservation Program, the Sloping Cropland Conversion Program, the Desertification Combating Program, and the Protection Forest System Construction Program. There is a growing need to quantify the contributions of these programs to regional carbon stocks.However, the lack of widely accepted, robust methods is one of the key obstacles to quantification. The objective of this study was to review existing methods for quantifying regional carbon stocks and then recommend suitable ones for the Chinese ecological engineering programs. We expect that the recommended methods can be applied to elsewhere in the world where there are similar characteristics and objectives. | Ji Zheng Xiaohua Wei Yuanqiu Liu Guohua Liu Weifeng Wang Wenfei Liu | 2016 | Journal of Forestry Research2016，27，4： | 3 |
| 20 | A dendrite-free Li plating host towards high utilization of Li metal anode in Li–O_2 battery显示文摘The intense interest of Li–O_2 battery stems from its ultrahigh theoretical energy density, but its application is still hindered by the issues of Li anode. Herein, RuO_2-CNTs composite, a conventional O_2 cathode catalyst in Li–O_2 battery, is first utilized as an anode host for dendrite-free Li plating/stripping with high Coulombic efficiency. It is demonstrated that such excellent plating/stripping performance arises from the lithiophilicity characteristic of Ru nanoparticles(that is derived from the in-situ electrochemical conversion from RuO_2 to Ru/Li_2O) and buffer space provided by CNTs. Furthermore, the RuO_2-CNTs electrode pre-deposited with limited Li(RuO_2-CNTs@Li anode) is coupled with a RuO_2-CNTs catalytic cathode to form a Li–O_2 full cell, which displays an extended cycle life with dramatically improved energy density.The achieved cell shows a high stability of 200 cycles with RuO_2-CNTs@Li anode(1 mg Li) that sheds light on the efficient utilization of Li anode in Li–O_2 batteries. | Chao Li Jishi Wei Panlong Li Wenfei Tang Wuliang Feng Jingyuan Liu Yonggang Wang Yongyao Xia | 2019 | Science Bulletin2019，64，7： | 3 |
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