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| 1 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 2 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 3 | Implementation of the quantum Fourier transform显示文摘 | Weinstein Y S Pravia M A Fortunato E M | 2001 | Phys Rev Lett2001，86，： | 1 |
| 4 | Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice显示文摘 | WEINSTEIN D M MIHM M J BAUER J A | 2000 | J Pharmacol Exp Ther2000，294，1： | 1 |
| 5 | Estrogen receptor-[alpha] signaling in osteoblast progenitors stimulates cortical bone accrual显示文摘 | Almeida Maria Iyer Srividhya Martin-Millan Marta Bartell Shoshana M Han Li Ambrogini Elena Onal Melda Xiong Jinhu Weinstein Robert S Jilka Robert L O’Brien Charles A Manolagas Stavros C | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 6 | Effect of cyclosporin A on DNA repair and cancer incidence in kid-ney transplant recipients 显示文摘 | Herman M Weinstein T Korzets A | 2001 | J Lab Clin Med2001，137，1： | 1 |
| 7 | Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice显示文摘 | Weinstein R S O'Brien C A Almeida M | 2011 | Endocrinology2011，152，9： | 1 |
| 8 | Cardiac troponin T is essential in sarcomere assembly and cardiac contractility显示文摘 | Sehnert A J Huq A Weinstein B M | 2002 | Nat Genet2002，31，1： | 1 |
| 9 | Pyrolytic carbon an alternative implant material in orthopedic surgery显示文摘 | WEINSTEIN A M | 1984 | Mech e1984，202，： | 1 |
| 10 | Postoperative spinal wound infection:a review of 2,391 consecutive index procedures显示文摘 | Weinstein M A McCabe J P Cammisa F P Jr | 2001 | J Spinal Disord2001，13，5： | 1 |
| 11 | Inherited diseases involvingG proteins and G protein -coupled receptors 显示文摘 | SPIEGEL A M WEINSTEIN L S | 2004 | Annu RevMed2004，55，： | 1 |
| 12 | Multichannel signal separation by decorrelation显示文摘 | Weinstein E Feder M Openheim A V | 1993 | IEEE Transactions on Speech and Audio Processing1993，1，4： | 1 |
| 13 | Inappro-priate expression of hepcidin is associated with iron re-fractory anemia: implication for the anemia of chronic disease显示文摘 | Weinstein D A Roy C N Fleming M D | 2002 | Blood2002，100，10： | 1 |
| 14 | Inappropriate Expression of Hepcidin is Associated with Iron Refractory Anemia:Implications for the Anemia of Chronic Disease显示文摘 | Weinstein D A Roy C N Fleming M D | 2002 | Blood2002，100，10： | 1 |
| 15 | Photos vs silhou- ettes for evaluation of African American profile esthetics显示文摘 | Hockley A Weinstein M Borislow A J | 2012 | Am J Orthod Dentofacial Orthop2012，141，2： | 1 |
| 16 | The microRNAs of Caenorhabditiselegans显示文摘 | Lim L Lau N Weinstein E Abdelhakim A Yekta S Rhoades M Burge C Bartel D | 2003 | Genes & Dev2003，，： | 1 |
| 17 | Fibroblast growth factors in regenerating limbs of ambystoma : cloning and semiquantitative RT- PCR expression studies 显示文摘 | Christensen R N Weinstein M Tassava R A | 2001 | Exp Zool2001，290，5： | 1 |
| 18 | Leibniz algebras,Courant algebroids,and multiplications on homogeneous spaces显示文摘 | Kinyon M K Weinstein A | 2001 | AmerJ Math2001，123，： | 1 |
| 19 | Sonic hedgehog and vascular endothelial growth factor act upstream of the notch pathway dnring arterial endothelial differentiation显示文摘 | LAWSON N D VOGEL A M WEINSTEIN B M | | 0，，01： | 1 |
| 20 | Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages显示文摘 | WEINSTEIN S L GOLD M R DEFRANCO A L | 1991 | Proc Natl Acad Sci USA1991，88，10： | 1 |
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