|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 2 | All mutually unbiased bases in dimension two to five显示文摘 | Brierley S Weigert S Bengtsson I | 2010 | Quantum In{orm Comput2010，10，： | 1 |
| 3 | Construction of a functional S-layer fusion protein comprising an immunoglobulin G-binding domain for development of specific adsorbents for extracorporeal blood purification显示文摘 | Vollenkle C Weigert S Ilk N | 2004 | Appl Environ Microbiol2004，70，3： | 1 |
| 4 | Plasma levels of leptin,oment-in,collagenous repeat-containing sequence of26-kDa protein(CORS-26)and adiponectin before and after oral glucose uptake in slim adults显示文摘 | Wurm S Neumeier M Weigert J | 2007 | Cardiovasc Diabetol2007，20，6： | 1 |
| 5 | The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages显示文摘 | Ley S Weigert A Weichand B | 2013 | Oncogene2013，32，5： | 1 |
| 6 | Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26 kD protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults显示文摘 | Wurm S Neumeier M Weigert J | 2007 | Cardiovasc Dialoetol2007，6，： | 1 |
| 7 | PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis 显示文摘 | Schiffmann S Weigert A Mannieh J | 2014 | Biochem Pharmacol2014，87，4： | 1 |
| 8 | H ypoxia en- hances sphingosine kinase 2 activity and provokes sphingosine-l-phosphate-mediated chemoresistance in A549 lung cancer cells显示文摘 | Schnitzer S E Weigert A Zhou J Brtine B | 2009 | Mol Cancer Res2009，7，： | 1 |
| 9 | An empirical analysis of multivariate copula models显示文摘 | Fischer M K6ck C Schliiter S Weigert F | 2009 | Quantitative Finance2009，9，7： | 1 |
| 10 | Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis显示文摘 | Waerntges S Klingel K Weigert C | 2002 | Cell Physiol Biochem2002，12，23： | 1 |
| 11 | Intravitreal bevaeiznmab (Avastin) therapy versus photodynamic therapy plus intravitreal triamcinolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomised, controlled clinical study 显示文摘 | Weigert G Michels S Seau S | 2008 | Br J Ophthalmol2008，92，3： | 1 |
| 12 | Adiponectin-induced secretion of interleukin-6 (IL-6),monocyte chemotactic protein-1 (MCP-1,CCL2),and interleukin-8 (IL-8,CXCL8) is impaired in monocytes from patients with type Ⅰ diabetes显示文摘 | Abke S Neumeier M Weigert J | | 0，，： | 1 |
| 13 | Quantum correlation games显示文摘 | Iqbal A Weigert S | 2004 | Journal of Physics A: Mathematical and General2004，37，22： | 1 |
| 14 | Electric conductivity near the percolation transition of a nonionic water-in-oil microemulsion显示文摘 | Weigert S Eicke H F Meier W | 1997 | Physica A1997，242，12： | 1 |
| 15 | Excessive transcription of the human serum and glucocorticoid-dependent kinase hSGK1 in lung fibrosis显示文摘 | WAEMTGES S KLINGEL K WEIGERT C | 2002 | Cell Physiol Biochem2002，12，23： | 1 |
| 16 | An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostatespecific antigen by surface plasmon resonance technology 显示文摘 | Pleschberger M Saerens D Weigert S | 2004 | Bioconjug Chem2004，15，： | 1 |
| 17 | Excessive transcription the human serum and glucocorticoid-dependent kinase hSGK1 in lung fibrosis显示文摘 | Waemtges S Klingel K Weigert C | 2002 | Cell Physiol Bioehem2002，12，23： | 1 |
| 18 | An S-layer heavy chain camel antibody fusion protein for generating of a nanopattemed sensing layer to detect the prostate specific antigen by surface plasmon resonance technique显示文摘 | Pleschberger M Saerens D Weigert S | 2004 | Bioconjug Chem2004，15，3： | 1 |
| 19 | Optimization of manufacturing process by distributed simulation显示文摘 | Weigert G Horn S Werner S | 2006 | International Journal of Production Research2006，44，： | 1 |
| 20 | Evaluation of anterior chamber inflammatory activity in eyes treated with intravitreal bevacizumab显示文摘 | Kiss C Michels S Prager F Weigert G Geitzenauer W Schmidt-Erfurth U | 2006 | Retina2006，26，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员