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| 1 | 感染性休克病人的血流动力学特点及意义显示文摘目的 了解感染性休克病人早期血流动力学改变的特点及与预后关系。方法 临床前瞻性研究 ,监测感染性休克早期血流动力学改变并分析与预后的关系。结果 共连续观察 4 8例病人 ,其中 2 5例(5 2 % )死亡。一些指标的水平在死亡者与生存者间差别较大 ,其中包括平均肺动脉压 (MPAP)、肺动脉楔压 (PAWP)、体 /肺循环阻力指数 (SVRI/PVRI)、左 /右心做功 (LCW/RCW )和左 /右心每搏动 (LCSW/RCSW)等血流动力学指标和氧合指数、动脉混合静脉血含氧量差 (a vDO2 )、全身性炎症反应综合征(SIRS)指标积分等。结论 感染性休克病情凶险 。 | 赵擎宇 贾清颜 Weigand MA Martin E Bardenheuer HJ | 2002 | 中华急诊医学杂志2002，11，3： | 16 |
| 2 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 3 | Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?显示文摘While cardiopulmonary symptoms are common in patients undergoing classical or, due to physical exercise, exertional heat stroke, the failure of other organs is a rarely described phenomenon. Here we present two cases of acute hepatic failure, one due to classic heat shock, while the other occurred while the patient was doing a marathon-type running. Both cases presented with very high transaminases and significantly elevated international normalized ratio (INR). No other causes for liver failure could be identified but physical exhaustion and hyperthermia. | Kilian Weigand Carina Riediger Wolfgang Stremmel Christa Flechtenmacher Jens Encke | 2007 | World Journal of Gastroenterology2007，13，2： | 8 |
| 4 | 重症败血症患者炎性介质水平对预后的影响显示文摘目的 :探索可早期预测败血症预后的炎性介质指标。方法 :前瞻性研究 ,观察期 2 8日 ,分析重症败血症患者与死亡相关的临床和实验室指标。结果 :共连续观察 2 6例 ,死亡 14例 (5 3.8%) ,且多死于研究阶段的第1周内 (74.0 %)。死亡组患者血总胆红素水平、4项全身炎性反应综合征 (SIRS)指标的积分和循环中的细胞间黏附分子 1(s ICAM 1)水平明显高于死亡组 ,其它炎性因子包括一些细胞因子和黏附分子的水平在 2组间差异不大。结论 :败血症患者的 s ICAM | 赵擎宇 张春玲 黄子通 M A Weigand H J Bardenheuer E Martin | 2001 | 中国危重病急救医学2001，13，11： | 7 |
| 5 | 小角弹性光散射粒径测量技术与准确性验证显示文摘改变了用中心有孔的环形光电元件接收前向散射光的传统做法,选择采用高灵敏度、低噪声、高分辨率带冷却的CCD采集散射光。采用光导纤维使透射光导出光轴,从CCD采集到的图像得到光强随散射角变化的分布曲线,用米氏散射程序反算出粒径分布;采用CCD为接收设备提高了测量系统的灵敏度和角度分辨率,使测量稀薄液雾或悬浊液的粒径分布成为可能。尽管激光散射粒径测量方法从测量原理上看更加准确,但此测量技术不是利用颗粒的放大成像确定粒径,不直观,通常需要验证激光粒径测量结果的准确性,常采用经其他光学方法测量过的标准粒子验证。提出了一种非光学的准确性验证方法,即利用单分散液滴串发生器产生的大小可控的等直径、等间距液滴串来验证小角弹性光散射粒径测量系统的准确性。 | 孙晗 Grazia Lamanna Bernhard Weigand | 2013 | 中国激光2013，40，3： | 7 |
| 6 | Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation显示文摘BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following transplantation.This study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following OLT.METHODS:Eighty-six patients undergoing OLT were included in this single-centre trial.ICG-PDR was assessed daily for the first 7 days following OLT.Endpoints were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 days.RESULTS:Postoperative complications of 31 patients included deaths (12 patients) or graft losses.ICG-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after OLT.For day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following OLT.The added value over that of routinely determined laboratory parameters is low. | Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand Jan Schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 6 |
| 7 | Effects of Staged Injection on Supersonic Mixing and Combustion显示文摘The three-dimensional (3D) reacting flow in a staged supersonic combustor is examined numerically. In order to obtain the optimum stream-wise vortices, a swept ramp injector is chosen as the second-stage wall injection combined with the first-stage central strut injection. The performance of the two-staged injection is compared with that of a one-staged injection, while the strut is kept installed in both cases. The two-staged injections can make full use of the residual oxygen near the wall and release more heat. The second-stage injection further downstream avoids the strong shock waves in the isolator and results in a rising wall pressure and good burning effects after the wall injection. Therefore, it allows more fuel to be injected into the supersonic combustor without causing thermal choking. Parallel injection from the second-stage swept ramp shows low total pressure loss and the best burning efficiency, compared with the other injection angles. | HOU Lingyun Bernhard WEIGAND Marius BANICA | 2011 | Chinese Journal of Aeronautics2011，24，5： | 6 |
| 8 | Treatment of hepatitis C virus infection显示文摘Acute and chronic hepatitis C virus (HCV) infection remains a serious health problem worldwide, however, there has been advancement in the treatment of HCV infection due to standard treatment using pegylated interferon and ribavirin. The literature indicates that therapy for HCV is becoming more individualized. In addition to considering genotype and viral RNA levels before treatment, achievement of an early virologic response (EVR) and a rapid virologic response (RVR) is now possible during therapy. Moreover, problem patients, such as non-responders, relapsers, HIV or HBV co- infected patients, patients with liver cirrhosis, and pre- or post-liver transplantation patients are an increasing fraction of the patients requiring treatment. This article reviews the literature regarding standard treatments and problem patients with acute and chronic HCV infection. It also includes discussion on contraindications and side effects of treatment with interferon and ribavirin, as well as new drug development. | Kilian Weigand Wolfgang Stremmel Jens Encke | 2007 | World Journal of Gastroenterology2007，13，13： | 4 |
| 9 | Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology显示文摘 | Kilian Weigand Sylvia Brost Niels Steinebrunner Markus Büchler Peter Schemmer Martina Müller John J. Lemasters | 2012 | HPB Surgery2012，，： | 4 |
| 10 | Lack of correlation between Treg quantification assays in inflammatory bowel disease patients显示文摘AIM:To compare the number of regulatory T-cells( Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR(q PCR) method in patients suffering from inflammatory bowel disease(IBD).METHODS:Tregs percentages obtained by both flow cytometry and q PCR methods in 35 adult IBD patients,18 out of them with Crohn′s disease(CD)and 17 with ulcerative colitis(UC)were compared to each other as well as to scores on two IBD activity questionnaires using the Harvey Bradshaw Index(HBI)for CD patients and the Simple Colitis Clinical Activity Index(SCCAI)for UC patients.The Treg percentages by flow cytometry were defined as CD4+CD25highCD127lowFOXP3+cells in peripheral blood mononuclear cells,whereas the Treg percentages by q PCR method were determined as FOXP3 promoter demethylation in genomic DNA.RESULTS:We found an average of 1.56%±0.78%Tregs by using flow cytometry,compared to 1.07%±0.53%Tregs by using q PCR in adult IBD patients.There were no significant correlations between either the percentages of Tregs measured by flow cytometry or q PCR and the HBI or SCCAI questionnaire scores in CD or UC patients,respectively.In addition,there was no correlation between Treg percentages measured by q PCR and those measured by flow cytometry(r=-0.06,P=0.73;Spearman Rho).These data suggest that,either Treg-related immune function or the clinical scores in these IBD patients did not accurately reflect actual disease activity.Until the cause(s)for these differences are more clearly defined,the resultssuggest caution in interpreting studies of Tregs in various inflammatory disorders.CONCLUSION:The two methods did not produce equivalent measures of the percentage of total Tregs in the IBD patients studied which is consistent with the conclusion that Tregs subtypes are not equally detected by these two assays. | Gunnar Brandhorst Darinka Todorova Petrova Sebastian Weigand Christoph Eberle Nicolas von Ahsen Jessica Schmitz Frank Christian Schultze Dirk Raddatz Michael Karaus Michael Oellerich Philip D Walson | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 11 | 冲击射流结构中应用粗糙表面的实验研究显示文摘在单侧开口的冲击射流冷却结构中,逐步增加的横流将影响冲击板上的对流换热效率,本文提出了压窝板和肋片板两种粗糙冲击板构型,增加横流的扰动以减少对冲击流的影响并且增大横流与壁面的对流换热。实验采用瞬态热敏液晶测量方法,可以得到大尺度壁面的二维对流换热系数分布,可以较为系统地分析压窝及肋片周围的局部换热系数分布。通过实验研究,发现压窝板可以显著增大平均换热系数,而肋片板降低了平均换热系数。 | 邢云绯 仲峰泉 张新宇 Bernhard Weigand | 2012 | 工程热物理学报2012，33，9： | 2 |
| 12 | Fast Track—Different Implications in Pancreatic Surgery显示文摘 | P. O. Berberat H. Ingold A. Gulbinas J. Kleeff M. W. Müller C. Gutt M. Weigand H. Friess M. W. Büchler | 2007 | Journal of Gastrointestinal Surgery2007，，： | 2 |
| 13 | Serial PIB andMRI in normal,mild cognitive impairment and Alzheimer’sdisease:implications for sequence of pathological events inAlzheimer’s disease显示文摘 | Jack CR Jr Lowe VJ Weigand SD | 2009 | Brain2009，132，： | 1 |
| 14 | Interfacial tension between water and non-polar fluids up to 473 K and 2800 bar 显示文摘 | WEIGAND G and FRANCK E U | 1994 | Berichte der Bunsengesellschaft Fuel Physikalische Chemie1994，98，6： | 1 |
| 15 | TNF-related apoptosis-inducing ligand mediates tumoricidal activity of hu- man monocytes stimulated by Newcastle disease virus显示文摘 | Washburn B Weigand M A Grosse-Wilde A | 2003 | J Immunol2003，170，18： | 1 |
| 16 | TREM-1 amplifies inflammation and is a crucial mediator of septic shock显示文摘 | Bouchou A Facchetti F Weigand M A | | 0，，6832： | 1 |
| 17 | Perioperative fluid man- agement: an analysis of the present situation显示文摘 | Zausig YA Weigand MA Graf BM | 2006 | Anaesthesist2006，55，4： | 1 |
| 18 | Perioperative intra- venous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery显示文摘 | Kopper W Weigand M Neumann F | 2004 | Anesth Analg2004，98，： | 1 |
| 19 | TREM-1 amplifies inflammation and is a crucial mediator of septic shock显示文摘 | Bouchon A Facchetti F Weigand M A | 2001 | Nature2001，410，6832： | 1 |
| 20 | TREM-1amplifies inflammation and is a crucial mediator of septicshock显示文摘 | Bouchon A Facchetti F Weigand MA | 2001 | Nature2001，410，6832： | 1 |
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