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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Insect flight speed estimation analysis based on a full-polarization radar显示文摘Dear editor,As most migratory insects are nocturnal, the entomological radar with the advantage of all-time and all-weather application is the most effective technique for insect migration observation [1]. Generally, the current entomological radar could be categorized into the scanning radar and verticallooking radar (VLR). The aerial density of migration could be measured by the scanning radar,while the flight speed, displacement direction, | Cheng HU Wenqing LI Rui WANG Yuanhao LI Weidong LI Tianran ZHANG | 2018 | Science China(Information Sciences)2018，61，10： | 9 |
| 3 | Spatial difference and mechanisms of influence of geo-economy in the border areas of China显示文摘Border areas are both important territorial security barriers and portals to the outside world. Considering the complicated geopolitical environment of China's inland borders, analysis of the current status and mechanisms of influence of geo-economy in border areas is of great significance. Namely, this analysis is important towards leveraging traditional advantages to accelerate China's development in border and minority areas. Based on a comprehensive analysis, our study constructed a framework to analyze the geo-economy in border areas, and also introduced three indexes: local economy, export-oriented economy and local development. In addition, our study systematically described geo-economic evolution in the border areas of China. We also analyzed the mechanism of geo-economic spatial differentiation in these border areas by using geographical detectors. Our results indicated that the level of geo-economic influence in border areas has grown steadily with significant spatial differentiation. The absolute geo-economic dominance of Northeast China gradually declines over time. Areas with geo-economic advantages are highly dispersed, showing a spatial polarization pattern with several polar nuclei including Mudanjiang city(Northeast China), Baotou city(Inner Mongolia), Bortala Mongol Autonomous Prefecture(Xinjiang), Dehong Dai and Jingpo Autonomous Prefecture and the city of Chongzuo(Yunnan-Guangxi area). Geo-economics in border area is mainly influenced by national policies, the development level of neighboring countries, as well as the desire of these countries to cooperate with China in bilateral trade. Favorable policies, traffic, cultural proximity and other factors also impact the geo-economics of border areas significantly. The Inner Mongolia and Tibet areas are mainly influenced by neighboring countries, while Northeast China and Xinjiang are mainly affected by Chinese policies; the Yunnan-Guangxi area is influenced by a combination of these factors. At the end of the study, we provide our recommendations for developing policies that further geo-economic advantages in complex geopolitical environments and in areas with varied development. | SONG Tao CHENG Yi LIU Weidong LIU Hui | 2017 | Journal of Geographical Sciences2017，27，12： | 9 |
| 4 | Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model显示文摘Background:Neuron-microglia communication plays a crucial role in the motor neurons(MNs)death in amyotrophic lateral sclerosis(ALS).Neurons can express chemokine(C-X3-C motif)ligand 1(CX3CL1),which mediates microglial activation via interacting with its sole receptor CX3CR1 in microglia.In the present study,we aimed to investigate the dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and MNs loss in SOD1G93A mouse model of ALS.Methods:qPCR,western blot and immunofluorescent staining were used to examine the mRNA and protein levels and localization of CX3CL1/CX3CR1 in the anterior horn region of spinal cord in both SOD1G93A mice and their agematched wild type(WT)littermates at 40,60,90 and 120 days of age.The M1/M2 microglial activation in the spinal cord tissues of SOD1G93A mice and WT mice were evaluated by immunofluorescent staining of M1/M2 markers and further confirmed by qPCR analysis of M1/M2-related cytokines.Results:The immunofluorescent staining revealed that CX3CL1 was predominately expressed in MNs,while CX3CR1 was highly expressed in microglia in the anterior horn region of spinal cord.Compared with age-matched WT mice,CX3CL1 mRNA level was elevated at 40 days but decreased at 90 and 120 days in the anterior horn region of spinal cords in ALS mice.Consistently,CX3CR1 mRNA level was increased at 90 and 120 days.Western blot assay further confirmed the dynamic changes of CX3CL1/CX3CR1 axis in ALS mice.Additionally,the levels of M1/M2 markers of microglia and their related cytokines in the anterior horn region of spinal cord in ALS mice were increased at 90 and 120 days.Moreover,while M1-related cytokines in ALS mice were persistently increased at 120 days,the upregulated M2-related cytokines started to decline at 120 days,suggesting an altered microglial activation.Conclusions:Our data revealed the dynamic changes of CX3CL1/CX3CR1 axis and an imbalanced M1/M2 microglial activation during ALS pathological progression.These findings may help identify potential molecular targets for ALS therapy. | Jingjing Zhang Yufei Liu Xinyao Liu Song Li Cheng Cheng Sheng Chen Weidong Le | 2018 | Translational Neurodegeneration2018，7，1： | 7 |
| 5 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
| 6 | A THRESHOLD BLIND SIGNATURE FROM WEIL PAIRING ON ELLIPTIC CURVES显示文摘The idea behind a (t, n) threshold blind signature is that a user can ask at least t out of n players of a group to cooperate to generate a signature for a message without revealing its content. This paper first presents a new blind signature scheme from Weil pairing on elliptic curves. Based on this scheme, a threshold blind signature scheme is proposed. It is efficient and has the security properties of robustness and unforgeability. In the proposed scheme, the group manger is introduced to take the role of distributing the group secret key to each player. However, he cannot forge the players to generate partial blind signatures (Each partial blind signature depends on not only the secret key of the player, but also a random number the player picks). Compared with a threshold signature with a trusted third party, its advantage is obvious; Compared with a threshold signature without a trusted third party, it is more simple and efficient. | Cheng Xiangguo Xu Weidong Wang Xinmei | 2006 | Journal of Electronics(China)2006，23，1： | 6 |
| 7 | Variations of energy metabolism and adenosine Triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of Zhiweifangbian capsule显示文摘OBJECTIVE: To study the effects of Zhiweifangbian (ZWFB) capsule on lactic dehydrogenase (LDH), succinic dehydrogenase (SDH) and ATPase activities in gastric mucosa of chronic atrophic gastritis (CAG) rats with Qi deficiency and blood stasis syndrome. METHODS: Totally 90 rats were randomly divided into 2 groups: normal group (n=10) and modelgroup (n=80). The CAG rat model of Qi deficiency and blood stasis type was induced by synthetic methods. After modeling for 12 weeks and the successful CAG model was determined, the CAG model rats were divided by random number table into model group (MG), ZWFB high-dose group (ZWFBH), ZWFB middle-dose group (ZWFBM), ZWFB low-dose group (ZWFBL) and Weimeisu group (WM), 9 rats in each group. The rats in the normal and model groups were intragastrically administrated with distilled water, 10 mL/kg every day; the ZWFB high-dose group with ZWFB, 0.6 g/ kg -1 · d -1 ; the ZWFB middle-dose group with ZWFB, 0.3 g/kg -1 · d -1 ; the ZWFB low-dose group with ZWFB, 0.15 g/kg -1 · d -1 , and the WM group with suspension of WM , 0.25 g/kg -1 · d -1 . The treatment was given for 90 consecutive days. Then general survival states were observed and the activities of LDH, SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase in gastric mucosa tissue were detected. RESULTS: Compared with the normal group, activity of LDH in the gastric mucosa (P<0.05) and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly decreased in the normal group (P<0.05). Compared with the model group the activity of LDH decreased and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly increased in the high dose ZWFB group (P<0.05). CONCLUSION: ZWFB capsule can promote energy metabolism and ATPase activity in the gastric mucosa cell, so as to protect the function of the gastric mucosa cell. | Yongqiang Duan Weidong Cheng Yingxia Cheng Hongyan Li Xueyan Li Liming Zhu Xiaoyi Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 6 |
| 8 | Influences of accumulated mileage and technological changes on emissions of regulated pollutants from gasoline passenger vehicles显示文摘In this study, the influences of accumulated mileage(deterioration) and technological changes(emission standards) on emission factors(EFs) of regulated pollutants(CO, HC, and NO_x) from gasoline passenger vehicles were investigated based on Inspection and Maintenance(I/M) data using the chassis dynamometer method. The accumulated mileage of passenger vehicles was significantly linearly correlated with vehicle age. For most cases,the average EFs of CO, HC and NO_x were significantly linearly correlated with accumulated mileage, indicating that emission deterioration had a significant impact on pollutant EFs.Implemented emission standards markedly influenced the EFs of regulated pollutants, and EFs markedly decreased with progressing emission standards. The present study also compared EFs of regulated pollutants between this study and the International vehicle emission(IVE) model, and marked differences in EFs were seen with variations in emission standards, vehicle types and accumulated mileage; NO_x EFs in this study were higher than in the IVE model. The results provide new insight into estimating regulated pollutant emissions using the IVE model. | Qingyu Zhang Juwang Fan Weidong Yang Fang Ying Zhen Bao Yi Sheng Cheng Lin Xuan Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 5 |
| 9 | Receptor-interacting Protein 140 Overexpression Promotes Neuro-2a Neuronal Differentiation by ERK1/2 Signaling显示文摘 | Xiao Feng Weidong Yu Rong Liang Cheng Shi Zhuran Zhao Jingzhu Guo | 2015 | Chinese Medical Journal2015，，1： | 5 |
| 10 | Location patterns of urban industry in Shanghai and implications for sustainability显示文摘瓷器经济经历了快速的转变并且工业重构。术语城市的工业在中国城市经历重构以内描述工业的一种特别类型。给也从城市中心关门了或重定位到城市的穗并且在以外的工业公司的高百分比,突现的全球城市象上海那样,为本地经济、城市的开发正在实现策略,它在城市中心和城市的穗包含城市的工业升级的众多的公司。这研究试图用 2008 微地理的数据在上海城市的区域以内分析七个城市的工业扇区的地点模式。为了避免统一问题(MAUP ) 问题,包括最近的邻居分析的四项基于距离的措施,核密度评价, K 功能和合作地点的可修改的 Areal,商广泛地被使用了分析并且比较在七个部门之间的集中和合作地点。结果揭示也与距离和有趣的合作地点变化的迥异的模式。结果如下:城市中心和城市的穗从城市中心与 20-30 km 有城市的工业公司,而是地区的最高的紧张是为大多数范畴的一个分水岭;集中的度与距离变化,在更短的距离更弱,增加直到 30 km 的最大的距离然后减少直到 50 km;为所有城市的工业,有模式的三种类型,在距离的一个改变的范围的聚类的、随机、分散的分发的混合。因而,这份报纸主张城市的工业的地点模式思考阶段特定的工业重构和空间转变,由可持续性目的调节了。 | CAO Weidong LI Yingying CHENG Jianquan Steven MILLINGTON | 2017 | Journal of Geographical Sciences2017，27，7： | 5 |
| 11 | A Tuberculosis Outbreak at a School-Xinjiang Uygur Autonomous Region, China, 2019显示文摘Summary What is already known about this topic?Worldwide,tuberculosis(TB)continues to be the most important cause of death from a single infectious agent,and China has a high TB burden.Although the reported incidence of TB in students is lower than that in general population,TB outbreaks in schools have continuously been reported in the past years,suggesting that schools are a high-risk setting for TB transmission. | Senlu Wang Yan Cui Nianqiang Liu Xijiang Wang Xinqi Wang Weidong Wu Canyou Zhang Maiwulan Parehati Zhi Li Chunhui Yu Lijie Zhang Jun Cheng | 2020 | China CDC weekly2020，2，46： | 5 |
| 12 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 13 | Identification of Chromosomes from Multiple Rice Genomes Using a Universal Molecular Cytogenetic Marker System显示文摘为染色体鉴定开发可靠技术为细胞发生的研究是批评的,特别为有一个大数字和小尺寸的染色体的染色体。当分子的 cytologicalmarkers 为许多有机体被开发了,用细菌的人工的染色体(用绳子拖的平底渡船) 的 Anefficient 途径克隆。此处,我们在场一套 chromosomal arm-specificmolecular cytological 标记源于定序的米饭染色体的充实基因的区域。所有这些标记能在 Oryzasativa L 的 pachytene 染色体上产生很强壮的信号。(AA 染色体) 什么时候用作荧光原位杂交(鱼) ,探查。我们进一步探查了那些标记到 O 的 pachytene 染色体。punctata (BB 染色体) 和 O。依照药方(CCgenome ) 并且相关 pachytene 染色体上的也得到的很强壮的信号。从三个不同米饭染色体的相关染色体上的每个标记的信号位置是漂亮大部分桌子,它使我们能在各种各样的米饭染色体之中识别不同染色体。我们也为两 O 构造了核型。punctata 和 O。依照药方分别地,由 10 个 pachytene 房间的分析与 BB 和 CC 染色体由这些 chromosomal 抛锚了手臂特定的标记…… | Xiaomin Tang Weidong Bao Wenli Zhang Zhukuan Cheng | 2007 | Journal of Integrative Plant Biology2007，49，6： | 4 |
| 14 | Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation显示文摘Parkinson’s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD,usually appears long before obvious motor symptoms.Moreover,the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis,and it has emerged as a hot topic in PD research.In this review,we briefly introduce the circadian rhythm and circadian rhythm-related genes,and then summarize recent research progress on the altered circadian rhythm in PD,ranging from clinical features to the possible causes of PD-related circadian disorders.We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD,but also shed light on the better management of PD. | Yufei Liu Long Niu Xinyao Liu Cheng Cheng Weidong Le | 2021 | Neuroscience Bulletin2021，37，7： | 4 |
| 15 | Altered Motor Performance,Sleep EEG,and Parkinson’s Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2^(G2019S) Mice显示文摘Parkinson’s disease(PD)is a multifaceted disease in which environmental variables combined with genetic predisposition cause dopaminergic(DAergic)neuron loss in the substantia nigra pars compacta.The mutation of leucine-rich repeat kinase 2(Lrrk2)is the most common autosomal dominant mutation in PD,and it has also been reported in sporadic cases.A growing body of research suggests that circadian rhythm disruption,particularly sleep-wake abnormality,is common during the early phase of PD.Our present study aimed to evaluate the impact of sleep deprivation(SD)on motor ability,sleep performance,and PD pathologies in Lrrk2^(G2019S) transgenic mice.After two months of SD,Lrrk2^(G2019S) mice at 12 months of age showed an exacerbated PD-like phenotype with motor deficits,a reduced striatal DA level,degenerated DAergic neurons,and altered sleep structure and biological rhythm accompanied by the decreased protein expression level of circadian locomotor output cycles kaput Lrrk2 gene in the brain.All these changes persisted and were even more evident in 18-month-old mice after 6 months of follow-up.Moreover,a significant increase inα-synuclein aggregation was found in SD-treated transgenic mice at 18 months of age.Taken together,our findings indicate that sleep abnormalities,as a risk factor,may contribute to the pathogenesis and progression of PD.Early detection of sleep disorders and improvement of sleep quality may help to delay disease progression and provide long-term clinical benefits. | Xinyao Liu Hang Yu Yuanyuan Wang Song Li Cheng Cheng Murad Al-Nusaif Weidong Le | 2022 | Neuroscience Bulletin2022，38，10： | 3 |
| 16 | Joint Estimation of Carrier Frequency and Phase Offset Based on Pilot Symbols in Quasi-Constant Envelope OFDM Satellite Systems显示文摘Spectral efficiency and energy efficiency are two important performance indicators of satellite systems. The Quasi-Constant Envelope Orthogonal Frequency Division Multiplexing(QCE-OFDM) technique can achieve both high spectral efficiency and low peak-to-average power ratio(PAPR). Therefore, the QCE-OFDM technique is considered as a promising candidate multi-carrier technique for satellite systems. However, the Doppler effect will cause the carrier frequency offset(CFO), and the non-ideal oscillator will cause the carrier phase offset(CPO) in satellite systems. The CFO and CPO will further result in the bit-error-rate(BER) performance degradation. Hence, it is important to estimate and compensate the CFO and CPO. This paper analyzes the effects of both CFO and CPO in QCE-OFDM satellite systems. Furthermore, we propose a joint CFO and CPO estimation method based on the pilot symbols in the frequency domain. In addition, the optimal pilot symbol structure with different pilot overheads is designed according to the minimum Cramer-Rao bound(CRB) criterion. Simulation results show that the estimation accuracy of the proposed method is close to the CRB. | Cheng Wang Gaofeng Cui Weidong Wang Yinghai Zhang | 2017 | China Communications2017，14，7： | 3 |
| 17 | Frequency Offset Compensation for Satellite Communication System with CE-OFDM显示文摘Constant envelope orthogonal frequency division multiplexing(CE-OFDM) is a waveform that can achieve 0d B peak-to-average power ratio and avoid the signal distortion caused by the nonlinear power amplifi er. However, the carrier frequency offset(CFO) in CE-OFDM systems can cause errors at phase unwrapper module. In this paper, a CFO estimation scheme is proposed for CEOFDM in satellite communication system. As the null subcarrier is inherent in the conjugate symmetric symbol structure at the transmitter, the proposed scheme uses the null subcarrier as prior information to estimate the CFO at the receiver. The ideal estimation range of normalized CFO is obtained by mathematical analysis. Simulation results show that the proposed scheme can estimate the CFO accurately under additive white Gaussian noise(AWGN) channel and multipath fading channel, especially for moderate and high signal-to-noise ratio(SNR). | Gaofeng Cui Cheng Wang Weidong Wang Yinghai Zhang | 2017 | China Communications2017，14，8： | 3 |
| 18 | Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells显示文摘Akt 在反肿瘤代理人的发展正在成为一个吸引人的目标。在现在的学习,我们试图对恶意的 glioma 发现新奇否定 Akt 管理者。屏蔽站台在一根 Akt-GFP overexpression 房间线执行了的一个 Akt 管理者被开发,并且自然产品图书馆被屏蔽并且评估了使用这个平台。另外,管理者的细胞毒素的效果被 MTT 试金检测。房间 apoptosis 是由 Hoechst 33342 染色和流动 cytometry 分析的 assayed。以后,表明小径的 apoptotic 被西方的污点分析调查。Glaucocalyxin A,从 Rabdosia 孤立装饰用的梨树,作为一个有势力被识别 Akt 的否定管理者。在导出人的恶意的 glioma U87MG 房间, glaucocalyxin A 禁止了 Akt phosphorylation,压制了增长,并且支持了以一种剂量依赖者方式,然而并非在正常 glial 房间的 apoptosis。而且, glaucocalyxin A 激活 caspase-3,减少的坏 phosphorylation,并且减少了 apoptosis 的 X 连接禁止者的表示蛋白质。一起拿,这些结果显示 glaucocalyxin A 可以在恶意的 glioma 的处理成为一个有希望的候选人。 | Xian Xiao Weidong Cao Xiaofan Jiang Wei Zhang Yongqiang Zhang Bolin Liu Jinxiang Cheng Huiyong Huang Junli Huo Xiang Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 2 |
| 19 | Generalized Demodulation Transform for Bearing Fault Diagnosis Under Nonstationary Conditions and Gear Noise Interferences显示文摘It is a challenging issue to detect bearing fault under nonstationary conditions and gear noise interferences. Meanwhile, the application of the traditional methods is limited by their deficiencies in the aspect of computational accuracy and e ciency, or dependence on the tachometer. Hence, a new fault diagnosis strategy is proposed to remove gear interferences and spectrum smearing phenomenon without the tachometer and angular resampling technique. In this method, the instantaneous dominant meshing multiple(IDMM) is firstly extracted from the time-frequency representation(TFR) of the raw signal, which can be used to calculate the phase functions(PF) and the frequency points(FP). Next, the resonance frequency band excited by the faulty bearing is obtained by the band-pass filter. Furthermore, based on the PFs, the generalized demodulation transform(GDT) is applied to the envelope of the filtered signal. Finally, the target bearing is diagnosed by matching the peaks in the spectra of demodulated signals with the theoretical FPs. The analysis results of simulated and experimental signal demonstrate that the proposed method is an e ective and reliable tool for bearing fault diagnosis without the tachometer and the angular resampling. | Dezun Zhao Jianyong Li Weidong Cheng Zhiyang He | 2019 | Chinese Journal of Mechanical Engineering2019，32，1： | 2 |
| 20 | Carbon dots-confined CoP-CoO nanoheterostructure with strong interfacial synergy triggered the robust hydrogen evolution from ammonia borane显示文摘Ammonia borane(NH_(3)BH_(3),AB) is promising for chemical hydrogen sto rage;however,current systems for rapid hydrogen production are limited by the expensive noble metal catalysts required for AB hydrolysis.Here we report the design and synthesis of a highly efficient and robust non-noble-metal catalyst for the hydrolysis of AB at 298 K(TOF=89.56 molH_(2) min^(-1) molCo^(-1)).Experiments and density functional theory calculations were performed to explore the catalyst’s hybrid nanoparticle heterostructure and its catalytic mechanism.The catalyst comprised nitrogen-doped carbon dots confining CoO and CoP,and exhibited strong interface-induced synergistic catalysis for AB hydrolysis that effectively decreased the energy barriers for the dissociation of both AB and water molecules.The co-doping of N and P introduced numerous defects,and further regulated the reactivity of the carbon layers.The heterogeneous interface design technique presented here provides a new strategy for developing efficient and inexpensive non-noblemetal catalysts that may be applicable in other fields related to energy catalysis. | Han Wu Yaojia Cheng Boyang Wang Yao Wang Min Wu Weidong Li Baozhong Liu Siyu Lu | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
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