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| 1 | Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats显示文摘AIM: Gastrointestinal dysfunction is a common complication in patients with traumatic brain injury (TBI). However, the effect of traumatic brain injury on intestinal mucosa has not been studied previously. The aim of the current study was to explore the alterations of intestinal mucosa morphology and barrier function, and to determine how rapidly the impairment of gut barrier function occurs and how long it persists following traumatic brain injury.METHODS: Male Wistar rats were randomly divided into six groups (6 rats each group) including controls without brain injury and traumatic brain injury groups at hours 3,12, 24, and 72, and on day 7. The intestinal mucosa structure was detected by histopathological examination and electron microscopy. Gut barrier dysfunction was evaluated by detecting serum endotoxin and intestinal permeability. The level of serum endotoxin and intestinal permeability was measured by using chromogenic limulus amebocyte lysate and lactulose/mannitol (L/M) ratio, respectively.RESULTS: After traumatic brain injury, the histopathological alterations of gut mucosa occurred rapidly as early as 3 hours and progressed to a serious state, including shedding of epithelial cells, fracture of villi, focal ulcer, fusion of adjacent villi, dilation of central chyle duct, mucosal atrophy,and vascular dilation, congestion and edema in the villous interstitium and lamina propria. Apoptosis of epithelial cells,fracture and sparseness of microvilli, loss of tight junction between enterocytes, damage of mitochondria and endoplasm, were found by electron microscopy. The villous height, crypt depth and surface area in jejunum decreased progressively with the time of brain injury. As compared with that of control group (183.7±41.8 EU/L), serum endotoxin level was signnificantly increased at 3, 12, and 24 hours following TBI (434.8±54.9 EU/L, 324.2±61.7 EU/L and 303.3±60.2 EU/L, respectively), and peaked at 72 hours (560.5±76.2 EU/L), then declined on day 7 (306.7±62.4 EU/L,P<0.0L). Two peaks of serum endotoxin level were found at hours 3 and 72 following TBI. L/M ratio was also significantly higher in TBI groups than that in control group (control,0.0172±0.0009; 12 h, 0.0303±0.0013; 24 h, 0.0354±0.0025;72 h, 0.0736±0.0105; 7 d, 0.0588±0.0083; P<0.01).CONCLUSION: Traumatic brain injury can induce significant damages of gut structure and impairment of barrier function which occur rapidly as early as 3 hours following brain injury and lasts for more than 7 days with marked mucosal atrophy. | Chun-HuaHang Ji-XinShi Jie-ShouLi WeiWu Hong-XiaYin | 2003 | World Journal of Gastroenterology2003，9，12： | 36 |
| 2 | Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1显示文摘瞄准: 对老鼠的 ischemic 损害调查 glycyrrhizin (Gly ) 的 neuroprotective 效果针的绳索和原子蛋白质的可能的角色高活动性的组盒子 1 (HMGB1 ) 在这进程。 | GuGong Li-bangYuan LingHu WeiWu LiangYin Jing-liHou Ying-haiLiu Le-shunZhou | 2012 | Acta Pharmacologica Sinica2012，33，1： | 27 |
| 3 | Levels of vasoactive intestinal peptide,cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction显示文摘AIM:To study the alterations of brain-gut peptides following traumatic brain injury (TBI) and to explore the underlying significance of these peptides in the complicated gastrointestinal dysfunction.METHODS:Rat models of focal traumatic brain injury were established by impact insult method,and divided into 6 groups (6 rats each group) including control group with sham operation and TBI groups at postinjury 3,12,24,72h,and d 7.Blood and proximal jejunum samples were taken at time point of each group and gross observations of gastrointestinal pathology were recorded simultaneously.The levels of vasoactive intestinal peptide (VIP) in plasma,calcitonin gene-related peptide (CGRP) and cholecystokinin (CCK) in both plasma and jejunum were measured by enzyme immunoassay (EIA). Radioimmunoassay (RIA) was used to determine the levels of VIP in jejunum.RESULTS:Gastric distension,delayed gastric emptying and intestinal dilatation with a large amount of yellowish effusion and thin edematous wall were found in TBI rats through 12h and 72h, which peaked at postinjury 72h. As compared with that of control group (247.8±29.5ng/L), plasma VIP levels were significantly decreased at postinjury 3,12 and 24h (106.7±34.1ng/L, 148.7±22.8ng/L,132.8±21.6ng/L,respectively),but significantly increased at 72h (405.0±29.8ng/L) and markedly declined on d 7 (130.7±19.3ng/L).However,Plasma levels CCK and CGRP were significantly increased through 3h and 7d following TBI (126-691% increases),with the peak at 72 h.Compared with control (VIP, 13.6±1.4ng/g;CGRP,70.6±17.7ng/g);VIP and CGRP levels in jejunum were significantly increased at 3h after TBI (VIP,35.4±5.0ng/g;CGRP,103.8±22.1ng/g),and declined gradually at 12 h and 2d h (VIP,16.5±1.8ng/g,5.5±1.4ng/g;CGRP,34.9±9.7ng/g, 18.5±7.7ng/g),but were significantly increased again at 72 h (VIP, 48.7±9.5ng/g; CGRP,142.1±24.3ng/g),then declined in various degrees on d 7 (VIP, 3.8±1.1ng/g; CGRP, 102.5±18.1ng/g).The CCK levels in jejunum were found to change in a similar trend as that in plasma with the concentrations of CCK significantly increased following TBI (99-517% increases) and peaked at 72h.CONCLUSION:Traumatic brain injury can lead to significant changes of brain-gut peptides in both plasma and small intestine, which may be involved in the pathogenesis of complicated gastrointestinal dysfunction. | Chun-HuaHang Ji-XinShi Jie-ShouLi WeiWu wei-QinLi Hong-XiaYin | 2004 | World Journal of Gastroenterology2004，10，6： | 25 |
| 4 | Ultrasonic aspiration hepatectomy for 136 patients with hepatocellular carcinoma显示文摘AIM:To study the operativ injury,post-operative complications,the hospitalization time,the post-operative survival rate of ultrasonic aspiration hepatectomy with a domestic new type of ultrasonic surgical device in comparison with that of conventional techniques of hepatectomy.METHODS:A total136patients with hepatocellular carcinoma(HCC,including 13patinents in 1991and 124consecutive patients from July1995to December2000)underwent ultrasonic aspiration in liver resection(groupT)and 179 HCCpatients received conventional hepatectomy during the corresponding period(groupC).The results of the two groups were compared statistically.RESULTS:There was no significant difference in the mean operation time between groupT(152±11min)and C(144±11min).No operation or hospital edath occurred in both groups.In groupT,the mean volumes of bleeding(463±15ml)and bolld transfusion(381±12ml)were markedly less than those in groupC(557±20ml,and507±18ml,respectively,P<0.05).The mean hospitalization time of groupT(8.9±0.6d)was markedly shorter than that of groupC(11.7d±0.6d)(P<0.05).The incidence of complications in groupTwas markedly lower than in groupC,post-operative jaundice occurred in4/136and31/179,respectively(P<0.05).liver failurein0/136and2/179,cholorrhea in0/136and6/179,hydrothoraxin21/136and39/179(P<0.05).ascices in9/136and2/179,cholrrheain0/136and6/179,hydrothorax in21/136and 39/179(P<0.05),ascices in 9/136and 54/179,respectively(P<0.05),while the 3-year survival rate of groupT(64.2%)increased markedly as compared with that of groupC(55.7%)(P<0.01).CONCLUSION:The ultrasonic aspiration hepatectomy with a domestic new type of ultrasonic surgical device could evidently reduce the operative injury and post-operative complications,shorten the hospitalization,time and prolong the survivals of HCC,patients. | WeiWu Xin-BaoLin | 2002 | World Journal of Gastroenterology2002，8，4： | 6 |
| 5 | NONLINEAR DATA RECONCILIATION METHOD BASED ON KERNEL PRINCIPAL COMPONENT ANALYSIS显示文摘In the industrial process situation, principal component analysis (PCA) is a general method in data reconciliation.However, PCA sometime is unfeasible to nonlinear feature analysis and limited in application to nonlinear industrial process.Kernel PCA (KPCA) is extension of PCA and can be used for nonlinear feature analysis.A nonlinear data reconciliation method based on KPCA is proposed.The basic idea of this method is that firstly original data are mapped to high dimensional feature space by nonlinear function, and PCA is implemented in the feature space.Then nonlinear feature analysis is implemented and data are reconstructed by using the kernel.The data reconciliation method based on KPCA is applied to ternary distillation column.Simulation results show that this method can filter the noise in measurements of nonlinear process and reconciliated data can represent the true information of nonlinear process. | Yan Weiwu Shao HuiheDepartment of Automation,Shanghai Jiaotong University,Shanghai 200030, China | 2003 | Chinese Journal of Mechanical Engineering2003，16，2： | 6 |
| 6 | Polymer grafting modification of the surface of nano silicon dioxide显示文摘Based on the composite modification technology of the surface of nano silicon dioxide by non-soap emulsion polymerization, it is verified that there are polymer grafted on the surface of nano silicon dioxide. The modification mechanism and the bonding status on the surface of nano silicon dioxide after modification were suggested via the results of the infrared spectrum, transmission electronic microscope photograph and X-ray photoelectron spectrum. The hydroxyl formed by hydrolyzing of silane coupling agent reacts with hydroxyl on the surface of nano silicon dioxide to form Si-O-Si bonds by losing water molecules and hence the double bonds are introduced onto the surface of nano silicon dioxide. The surface of nano silicon dioxide is grafted with polymer through free radical polymerization between the double bonds on the surface of nano silicon dioxide and styrene under the action of initiating agent. The dispersibility of nano silicon dioxide and the controllability of surface modification of nano silicon dioxide can be greatly improved by the modification process. | WeiWu ShouciLu 等 | 2002 | Journal of University of Science and Technology Beijing2002，9，6： | 5 |
| 7 | Rapid and efficient method for isolating plant high molecular weight(HMW)DNA with high purity显示文摘PREPARATION of HMW DNA (Megabase-size) is the basis for construction of genomic library with large DNA inserts such as bacterial artificial chromosome (BAC) and yeast artificial chromosome (YAC), and for long-range physical mapping. It can also be used for the macro-study of repeat sequences. Since HMW DNA during preparation is inclined to be sheared physically and digested by internal nucleases, it is very difficult to prepare the HMW DNA. Initially, plant HMW DNA was prepared by embedding protoplasts in the low melting-point (LMP) agarose; however, it had several disadvantages: (ⅰ) Culture of protoplasts was time-consuming, costly and tedious. ( ⅱ ) It was only used successfully for limited | Fang Qiu Jianmin Fu Weiwu Xie Chuanyou Li Bin Wang | 1999 | Chinese Science Bulletin1999，44，4： | 4 |
| 8 | A combined method to model grain crushing with DEM显示文摘This paper presents a combined method to model grain crushing effects with discrete element method.This method combines the two most commonly used concepts to model grain crushing in DEM,i.e.the replacement method and the agglomerate method,so that it is both accurate and efficient.The method can be easily implemented.The performance is shown by several DEM simulations of biaxial tests.Particles with different crush-abilities are modeled.DEM simulation results with and without grain crushing are compared and discussed.The change of grain size distribution due to grain crushing is also investigated. | Jia Lin Erich Bauer WeiWu | 2020 | Geoscience Frontiers2020，11，2： | 4 |
| 9 | Determination of Feature Line Equation for Self-adapting Incremental Press Bending显示文摘The basic idea and method about determination of the feature line equations and how to apply them to the numerical control of the press bending of panel skins were introduced. Research indicates that it is feasible to realize the self adapting incremental press bending by adopting the feature line equation. The feature line equation, which is based on the database of the status of practical processes, can be adjusted in time, and the forming precision can be improved.It is important to correctly select and reasonably predict the feature line equations to enhance the accuracy of the incremental press bending based on the feature line database and algorithm. The determination of the feature line equation settles necessary data foundation for further research on the database of self-adapting incremental press bending, and it supplies a new clue for the development of self-adapting incremental press bending. | JinsongLIU ShihongZHANG YuansongZENG ZhiqiangLI WeiWU ZhongtangWANG YiXU LimeiREN | 2004 | Journal of Materials Science & Technology2004，20，6： | 4 |
| 10 | Spatiotemporal Changes of Vegetation Cover in Response to Climate Change on the Tibetan Plateau显示文摘The Tibetan Plateau is one of the most important ecological barriers in China. Resolving the internal relations and dynamics ruling the association between regional vegetation and climate change is important to understand and protect the regional ecosystems. Based on vegetation, temperature and precipitation data of the Tibetan Plateau from 2001 to 2010, we analyze the spatial and temporal variations of vegetation cover over the past 10 years and discuss the vegetation response to climate change using empirical orthogonal function and singular value decomposition. Our results reveal the following:(1) vegetation cover gradually decreases from the southeast to the northwest of the Tibetan Plateau;(2) vegetation cover has increased on the Tibetan Plateau over the past 10 years, mainly in the central and eastern zones; and(3) a significant positive relationship was suggested between vegetation cover during growing season and the temperature in the entire region and with precipitation in the central and southern zones. | LI Juncheng WANG Jianrong GONG Bin GAN Xiaoli HU Weiwu LIU Weiling | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 2 |
| 11 | Managing Soil Erosion Potential by Integrating Digital Elevation Models with the Southern China's Revised Universal Soil Loss Equation——A Case Study for the West Lake Scenic Spots Area of Hangzhou,China显示文摘In China,many scenic and tourism areas are suffering from the urbanization that results from physical development of tourism projects,leading to the removal of the vegetative cover,the creation of areas impermeable to water,in-stream modifications,and other problems. In this paper,the risk of soil erosion and its ecological risks in the West Lake Scenic Spots (WLSS) area were quantitatively evaluated by integrating the revised universal soil loss equation (RUSLE) with a digital elevation model (DEM) and geographical information system (GIS) software. The standard RUSLE factors were modified to account for local climatic and topographic characteristics reflected in the DEM maps,and for the soil types and vegetation cover types. An interface was created between the Arcinfo software and RUSLE so that the level of soil erosion and its ecological risk in the WLSS area could be mapped immediately once the model factors were defined for the area. The results from an analysis using the Arcinfo-RUSLE interface showed that the risk value in 93 % of the expanding western part of the WLSS area was moderate or more severe and the soil erosion risk in this area was thus large compared with that in the rest of the area. This paper mainly aimed to increase the awareness of the soil erosion risk in urbanizing areas and suggest that the local governments should consider the probable ecological risk resulting from soil erosion when enlarging and developing tourism areas. | WANG Weiwu | 2007 | Journal of Mountain Science2007，4，3： | 1 |
| 12 | The Characterization of a measure of information discrepancy显示文摘 | Fang Weiwu | 2000 | Information Sciences2000，125，： | 1 |
| 13 | Soft Sensing Modeling Based on Support Vector Machine and Bayesian Model Selection显示文摘 | Yan Weiwu Shao Huihe Wang Xiaofan | 2004 | Computers and Chemical Engineering2004，8，28： | 1 |
| 14 | The disagreement degree of multi-person judgments in additive structure 显示文摘 | FANG Weiwu | 1994 | Mathematical Social Sciences1994，28，2： | 1 |
| 15 | Relationship between pitch value or S/D ratio of torsion of cord and fetal outcome显示文摘 | Chun‐FangTian Mei‐huaKang WeiWu Li‐juanFu | 2010 | Prenat Diagn2010，，5： | 1 |
| 16 | Prediction of protein structural classes by a new measure of information discrepancy显示文摘 | JIN Lixia TANG Huanwen FANG Weiwu | 2003 | Computer Biology and Chemistry2003，27，3： | 1 |
| 17 | A Cut-peak Function Method for Global Optimization 显示文摘 | Wang Yuncheng Fang Weiwu | 2009 | Journal of Computational and Applied Mathematics2009，，230： | 1 |
| 18 | Soft sensing modeling based on support vector machines and Bayesian model selection 显示文摘 | Yan Weiwu | 2004 | Computers and Chemical Engineering2004，，28： | 1 |
| 19 | Godson-3:A scalable multicore RISC processor with x86 emulation显示文摘 | Hu Weiwu Wang Jian Gao Xiang | | 0，，02： | 1 |
| 20 | Soft Sensing Modeling Based on Support Vector Machine and Bayesian Model Selection显示文摘 | YAN Weiwu SHAO Huihe WANG Xiaofan | 2004 | Computers and Chemical Engineering2004，28，08： | 1 |
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