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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 5 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 6 | Hyperlipaemia intensifies the course of acute oedematous and acute necrotizing pancreatitis in the rat显示文摘 | Hopoauer B Ffiess H Weber A | 1996 | Gut1996，38，5： | 1 |
| 7 | Photopoly-met8 for holography显示文摘 | Smothers W K Monroe R M Weber A M | 1990 | SPIE1990，1212，： | 1 |
| 8 | Interface formation in infiltrated AI (Si)/diamond composites 显示文摘 | BEFFORT O KHALID F A WEBER L | 2006 | Diamond and Related Materials2006，15，9： | 1 |
| 9 | Improved acid neutralisation capacity assessment of iron carbonates by titration and theoretical calculation显示文摘 | Weber P A Thomas J E Skinner W M | 2004 | Applied Geochemistry2004，19，： | 1 |
| 10 | Zn(II) dependence of the Aeromonas hydrophila AE036 metallo-β-lactamase activity and stability显示文摘 | Valladares M H Felici A Weber G | 1997 | Biochemistry1997，36，11： | 1 |
| 11 | Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK eomplexes显示文摘 | Eblen S T Slack J K Weber M J Catling A D | 2002 | Mol Cell Biol2002，22，60： | 1 |
| 12 | Categorization of Scope 3 Emissions for Streamlined Enterprise Carbon Footprinting 显示文摘 | Huang Y A Weber C L Matthews H S | 2009 | Environmental Science & Technology2009，43，22： | 1 |
| 13 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 14 | Enhanced plasmid maintenance in a CSRT upon square-wave oscillations in the dilution rate显示文摘 | Weber A E San K Y | 1988 | Biotechnology Letters1988，10，8： | 1 |
| 15 | Immunization of broiler chicks by in ovo injection of infective stages of Eimeria显示文摘 | Weber F H Genteman K C LeMay M A | 2004 | Pouh Sci2004，83，： | 1 |
| 16 | Neuronal damage after moderate hypoxia and erythropoietin显示文摘 | Weber A Dzietko M Berns M | 2005 | Neurobiol Dis2005，20，2： | 1 |
| 17 | Anobjective time-integration procedure for isotropic rate-independentand rate-dependent elastic-plastic constitutive equations 显示文摘 | WEBER G G LUSH A M ZAVALIANGOS-A ANAND L | 1990 | Int JPlasticity1990，6，： | 1 |
| 18 | Comparison between the reactivity of commercial and synthetic TiO2 photocatalysts显示文摘 | PISCOPO A ROBERT D WEBER J V | 2002 | Journal of Photochem and Photobio A:Chemistry2002，139，： | 1 |
| 19 | Vendor Selection Criteria and Methods显示文摘 | Weber C A Current J R Benton W C | 1991 | European Journal of Operational Research1991，50，： | 1 |
| 20 | Unusual spinal arteriovenous duralfistula:digital subtraction and magnetic resonance angiography显示文摘 | Weber J Thron A Forsting M | 2009 | Klin Neuroradiol2009，19，2： | 1 |
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