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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Chemical Oxygen Demand Analysis of Waste Water Using Trivalent Mangunese Oxidant with Chloride Removal by Sodium Bismuthate Pretreatment显示文摘 | DONALD G M SCOTT V B WAYNE T B | 2001 | Water Environment Research2001，73，1： | 1 |
| 3 | Identification and distruption of the gene encoding the k-activated acetaldehyde dehydrogenase of Saccharomyces cerevisiae 显示文摘 | Wayne D T Philip G M | 1998 | FEMS Microbiology Letters1998，164，： | 1 |
| 4 | ACC/AHA Guidelines for the Management of Patients With ST - Elevation Myocardial Infarction -Executive Summary显示文摘 | Elliott M Antman Daniel T Anbe Paul Wayne Armstrong | 2004 | Circu- lation2004，110，： | 1 |
| 5 | Surface-mediated alignment of nematic liquid crystals with polarized laser light显示文摘 | WAYNE M GIBBONS P J SHANNON S T S | 1991 | Nature1991，351，： | 1 |
| 6 | Not All Responses to Breach are the Same:A Longitudinal Study Examining the Interconnection of Social Exchange and Psychological Contract Processes in Organizations 显示文摘 | Dulac T Coyle - Shapiro J A - M Henderson D Wayne S | 2008 | Academy of Management Journal2008，，6： | 1 |
| 7 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
| 8 | J Anal At Spectrom显示文摘 | WAYNE D M YOSHIDA T M VANCE D E | 1996 | 11:861-8691996，11，： | 1 |
| 9 | The present status of QSAR in toxicology 显示文摘 | Wayne Schultza T Cronin M T D Netzeva T I N | 2003 | Journal of Molecular Structure: THEOCHEM2003，622，： | 1 |
| 10 | Trust in Schools:A Conceptual and Empirical Analysis 显示文摘 | Megan T M & Wayne H | 1998 | Journal of Educational Administration1998，36，4： | 1 |
| 11 | Social networks and the performance of individuals and groups 显示文摘 | Span'owe R T Liden R C Wayne S J Kraimer M L | 2001 | The Academy of Management Jour- nal2001，44，2： | 1 |
| 12 | Removal of selected metal ions from aqueous solution using modified corncobs显示文摘 | Vaughan T C W Seo E M Wayne | 2001 | Bioresource Technology 20012001，，： | 1 |
| 13 | Knot, heart-wood and sapwood extractives related to VOCs from drying southem pine lumber 显示文摘 | Leonard I J Curry T M Wayne M G Richard H | 2000 | Journal of Wood Chemical and Technology2000，20，4： | 1 |
| 14 | Safety inputs, behaviors and injury severity 显示文摘 | PATRICK M WAYNE K T | 2001 | Applied Economics2001，33，： | 1 |
| 15 | Removal of selected metal ions from aqueous solution using modified corncobs 显示文摘 | Vaughan T Seo C W Wayne E M | 2001 | Bioresource Technology2001，78，2： | 1 |
| 16 | Discri ruination among Listeria monoeytogenes isolates using a mixed genome DNA microarray 显示文摘 | Bonacki M K Melissa J K Wayne T M | 2003 | Veterinary Microbiol2003，92，： | 1 |
| 17 | Long-term patterns in vegetation-site relationships in a southern appalachian forest显示文摘 | Katherine J Elliott James M Vose Wayne T Swank | 1999 | Journal of the Torrey Botanical society1999，，4： | 1 |
| 18 | Longterm patterns in vegetation-site relationships in a southern Appalachian forest显示文摘 | James M Vose Wayne T Swank | 1999 | Journal of the Torrey Botanical society1999，，4： | 1 |
| 19 | Global and local optimi zation using radial basis function response surface models 显示文摘 | Dale B M Walter J G Wayne L T | 2007 | Applied Mathematical Modelling2007，31，10： | 1 |
| 20 | Nitrogen deposition and cycling across an elevation and vegetation gradient in southern Appalachian forests显示文摘 | JENNIFER D K JAMES M V WAYNE T S | 2008 | International Journal of Environmental Studies2008，65，3： | 1 |
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