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23篇 您的检索式：作者名="Waugh JR"

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	题名	作者	年代	出处	被引量
1	Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity.	Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap	2015	World Journal of Experimental Medicine2015，5，3：	2
2	Arteriographic complications in the DSA era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，1：	1
3	Collaboration and Leadership for Effective Emergency Management显示文摘	William L Waugh Jr Gregory Streib	2006	Washington:Public Administration Review2006，66，6：	1
4	Arteriographic complications in the DSA era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，1：	1
5	Arteriographic complications in the DSA era 显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，：	1
6	Arteriographic complications in the DSA era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，1：	1
7	Ulnar tunnel syndrome 显示文摘	Waugh RP Pellegrini VD Jr	2007	Hand Clin2007，23，：	1
8	The Political Costs of Failure in the Katrina and Rita Disaster显示文摘	William L Waugh JR	2006	Annals of the Ameri- can Academy of Political and Social Science2006，，：	1
9	Synthesis of methanol:Partl Catalysts and kinetics显示文摘	CHNCHEN G C DENNYP J JENNINGS JR SPENCER M S WAUGH KC	1988	Appl Catal1988，36，：	1
10	Terrorism and tourism as logical companions显示文摘	Richter L K Waugh Jr W L	1986	Tourism Management1986，7，4：	1
11	The United States Experience with the Incident Command System: What We Think We Know and What We Need to Know More About显示文摘	Jensen J Waugh Jr W L	2014	Journal of Contingencies and Crisis Management2014，22，1：	1
12	Arteriographic complications in the DSA era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，1：	1
13	Arteriographic complications in the DSA era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，1：	1
14	Arteriographic complications in the DSA erea显示文摘	Waugh JR Sacharias N	1992	Radiography1992，182，1：	1
15	Arteriographic Complications in DSA Era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，3：	1
16	Arteriographic complications in the DSA era 显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，：	1
17	Arteriographic complications in the DSA era 显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，：	1
18	Arteriographic complications in DSA era显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，4：	1
19	Arteriographic Complications in DSA Era 显示文摘	Waugh JR Sacharias N	1992	Radiology1992，182，3：	1
20	Arteriographic complications in the DSA era显示文摘	Sacharias N	1992	Radiology1992，182，1：	1

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