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| 1 | Origin and therapy for hypertriglyceridaemia in type 2 diabetes显示文摘Hypertriglyceridaemia(HTG) is a risk factor for cardiovascular disease(CVD) in type 2 diabetes and is caused by the interaction of genes and non-genetic factors, specifically poor glycaemic control and obesity. In spite of statin treatment, residual risk of CVD remains high in type 2 diabetes, and this may relate to HTG and atherogenic dyslipidemia. Treatment of HTG emphasises correcting secondary factors and adverse lifestyles, in particular, diet and exercise. Pharmacotherapy is also required in most type 2 diabetic patients. Statins are the first-line therapy to achieve recommended therapeutic targets of plasma low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol. Fibrates, ezetimibe and n-3 fatty acids are adjunctive treatment options for residual and persistent HTG. Evidence for the use of niacin has been challenged by non-significant CVD outcomes in two recent large clinical trials. Further investigation is required to clarify the use of incretin-based therapies for HTG in type 2 diabetes. Extreme HTG, with risk of pancreatitis, may require insulin infusion therapy or apheresis.New therapies targeting HTG in diabetes need to be tested in clinical endpoint trials. The purpose of this review is to examine the current evidence and provide practical guidance on the management of HTG in type 2 diabetes. | Jing Pang Dick C Chan Gerald F Watts | 2014 | World Journal of Diabetes2014，5，2： | 2 |
| 2 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 3 | 显示文摘 | Kinloch A J Little M S G Watts J F | 2000 | Aeta Mater2000，48，： | 1 |
| 4 | Mathematical models for use in insect pest control显示文摘 | Watt K E F | 1961 | Canad Entomol Suppl1961，19，1： | 1 |
| 5 | Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism 显示文摘 | Chan D C Watts G F Ng T W | 2005 | Clin Chem2005，51，： | 1 |
| 6 | The effects of ω3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial显示文摘 | Trevor A Mori Valerie Burke Ian B Puddey Ashley B Irish Christine A Cowpland Lawrence J Beilin Gursharan K Dogra Gerald F Watts | 2009 | Journal of Hypertension2009，，9： | 1 |
| 7 | The Factorial Structure of the Gen- eral Aptitude Test Battery 显示文摘 | Watts F N Everitt B S | 1980 | Journal of Clinical Psychol- ogy1980，，1： | 1 |
| 8 | An XPS and ToF-SIMS investigation of the outermost nanometres of a poly (vinyiidene difluoride) coating 显示文摘 | Steven J Hinder Chris Lowe John F Watts | 2007 | Progress in Organic Coatings2007，，60： | 1 |
| 9 | The effect of current and speed on perimeter erosion in recovered armatures显示文摘 | Watt T Stefani F | 2005 | IEEE Transactions on Magnetics2005，41，1： | 1 |
| 10 | Surgical repair of pectus exca-vatum and carinatum显示文摘 | Robicsek F Watts LT Fokin AA | 2009 | Semin Thorac Cardiovasc Surg2009，21，1： | 1 |
| 11 | Controlling nitrate leaching in irrigated agriculture显示文摘 | Spalding R F Watts D G Schepers J S | 2001 | Journal of Environmental Quality2001，30，： | 1 |
| 12 | A study of electrochemically treated PAN-based carbon fibres by IGC and XPS 显示文摘 | LINDSAY B ABEL M WATTS J F | 2007 | Carbon2007，25，12： | 1 |
| 13 | Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism显示文摘 | Chan D C Watts G F Ng T W | 2005 | Clin Chem2005，51，： | 1 |
| 14 | A tissue-specific enhancer of the prostate-specific membrane antigen gene, FOLH1 显示文摘 | Watt F Martorana A Brookes DE | 2011 | Genomics2011，73，3： | 1 |
| 15 | Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity 显示文摘 | Ooi E M Watts G F Sprecher D L | 2011 | J Clin Endocrinol Metab2011，96，10： | 1 |
| 16 | Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus 显示文摘 | Chew G T Hamilton S J Watts G F | 2007 | Diabet Vase Res2007，4，： | 1 |
| 17 | Engraved ochres from the middle stone age levels at Blombos Cave,South Africa显示文摘 | Henshilwood CS d'Errico F Watts I | 2009 | Journal of Human Evolution2009，57，1： | 1 |
| 18 | Surgical repair of pectus excavatum and carinatum显示文摘 | Robicsek F Watts L T Fokin A A | 2009 | Semin Thorac Cardiovasc Surg2009，21，1： | 1 |
| 19 | Seperation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression显示文摘 | JONES P H WATT F M | 1993 | Cell1993，73，4： | 1 |
| 20 | A study of electrochemically treated PAN based carbon fibers by IGC and XPS显示文摘 | Lindsay B Abel M L Watts J F | 2007 | Carbon2007，45，12： | 1 |
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