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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Predictors of tuberculin reactivity among prospective Vietnamese migrants: the effect of smoking显示文摘 | Plant AJ Watkins RE Gushulak B O'Rourke T Jones W Streeton J Sang D | 2002 | Epidemiol Infect2002，128，1： | 1 |
| 3 | Distinct stages of myelination regulated by g-secretase and astroeytes in a rapidly myelinating CNS eoculture system显示文摘 | Watkins T A Emery B Mulinyawe S Barres B A | 2008 | Neuron2008，60，： | 1 |
| 4 | Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin显示文摘 | Jessop C E Tavender T J Watkins R H | 2009 | Journal of Biological Chemistry2009，284，4： | 1 |
| 5 | Results of plate fixation of type 1b olecranon fractures in 24 horses显示文摘 | Swor T M Watkins J P Bahr A | 2003 | Equine Vet J2003，35，7： | 1 |
| 6 | Physical activity and the presence and extent of calcified coronary atherosclerosis显示文摘 | Taylor AJ Watkins T Bell D | 2002 | Med Sci Sports Exerc2002，34，2： | 1 |
| 7 | Gratitude and happiness:Development of a measure of gratitude and relationships with subjective well-being显示文摘 | Watkins P.C Woodward K Stone T Kolts R.L | | 0，，： | 1 |
| 8 | Polymer/Metal nanocomposite synthesis in supercritical CO2 显示文摘 | Watkins J J McCarthy T J | 1995 | Chem Mater1995，，7： | 1 |
| 9 | The second extracellular loop dictates Occludin-mediated HCV entry显示文摘 | Liu S Kuo W Yang W Liu W Gibson G A Dorko K Watkins S C Strom S C Wang T | 2010 | Virology2010，407，1： | 1 |
| 10 | Photolysis of triadimenol显示文摘 | Clark T Watkins Dam | 1986 | Chemosphere1986，15，6： | 1 |
| 11 | Polymer/metal nanocomposite synthesis in supercritical CO2 显示文摘 | Watkins J J McCarthy T J | 1995 | Chem Mater1995，7，11： | 1 |
| 12 | Total Approach to Deposit Control on Newsprint Machine Using TMP and DIP Pulp Mix from Specialized Fixation of Individual Pulps to Retention 显示文摘 | Dechandt A Watkins T Pruszynski P | 2004 | Appita Journal2004，57，1： | 1 |
| 13 | Linear Programming for Flood Control in the Iowa and Des Moines Rivers显示文摘 | Needham J T Watkins D W Lund J R | 2000 | Journal of Water Resources Planning and Management2000，126，3： | 1 |
| 14 | Watkins, Azpeitia (Baeillariophyeeae) : related genera and promorphology显示文摘 | FRYXELL G A SIMS P A WATKINS T P | 1986 | System atic Botany Monographs1986，13，： | 1 |
| 15 | Gratitude and happiness: Development of a measure of gratitude, and relationships with subjective well-being显示文摘 | Watkins PC Woodward K Stone T | 2003 | Social Behavior and Personality2003，31，： | 1 |
| 16 | Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans显示文摘 | Watkins KE Paus T Lereh JP | 2001 | Cereb Cortex2001，11，： | 1 |
| 17 | Ecological and evolutionary consequences of desiccation tolerance in tropical fern gametophytes 显示文摘 | Watkins J E Mack M C Sinclair T R | 2007 | New Phytol2007，176，3： | 1 |
| 18 | Expression of the transcription factors snail,slug,and twist and their clinical significance in human breast cancer显示文摘 | Martin T A Goyal A Watkins G | 2005 | Ann Surg Oncol2005，12，6： | 1 |
| 19 | Gravity field of the moon from the gravity recovery and interior laboratory (Grail) mission显示文摘 | Zuber M T Smith D E Watkins M M | 2012 | Science2012，339，6120： | 1 |
| 20 | Expressionof the transcription factors snail,slug,and twist and their clinical significance in human breast cancer显示文摘 | MARTIN T A GOYAL A WATKINS G | 2005 | Ann Surg Oncol2005，12，6： | 1 |
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