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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | The effect of VE exposure on cadmium toxicity in mouse embryo cells in vitro 显示文摘 | Warren S Patel S Kapron CM | 2000 | Toxicology2000，142，： | 2 |
| 4 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 5 | Aggressive surgery for metastatic liver neuroendocrine tumors显示文摘 | Jeffrey A Norton Robert S Warren Mary G Kelly Marlene B Zuraek Robert T Jensen | 2003 | Surgery2003，，： | 2 |
| 6 | Stomach contents of juvenile Cobia, Rachycentron canadum, from the northern Gulf of Mexico 显示文摘 | Franks J S Garber N M Warren J R | 1996 | Fishery Bulletin1996，94，2： | 1 |
| 7 | Qiamtofuomg augmentation gluteoplasty outcomes:a comparison of three instruments used to measure gluteal projection显示文摘 | FERREIRA D M WARREN S M | 2007 | Aesthetic Plast Surg2007，21，： | 1 |
| 8 | Surface disturbance of cryptobiotic soil crusts: Nitrogenase activity,chlorophyll content,and chlorophyll degradation显示文摘 | Belnap J Harper K T Warren S D | 1994 | Arid Soil Research and Rehabilitation1994，8，： | 1 |
| 9 | Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor 显示文摘 | Warren H S Glennon M L Wainwright N | 1992 | Infect Immun1992，60，6： | 1 |
| 10 | Improved RT - PCR for diagnosis and epidemiological surveillance of rubella显示文摘 | Cooray S Warrener L Jin L | 2006 | J Clin Virol2006，35，1： | 1 |
| 11 | The Brunei slide: a giant sub- marine landslide on the northwest Borneo margin revealed by 3D seis- mic data 显示文摘 | Gee M J R Uy H S Warren J | 2007 | Marine Geology2007，246，： | 1 |
| 12 | Testing predictive validity of the communication composite of the communication and symbolic behavior scales显示文摘 | McCathren R B Yoder P J Warren S F | | 0，，01： | 1 |
| 13 | Multiple primary maligrant tumors,a survey of the literature and a statistical study 显示文摘 | Warren S Gates O | 1932 | Am J Cancer1932，16，2： | 1 |
| 14 | Multiple primary malignant tumors:a survey of the literature and a statistical study显示文摘 | Warren S Gates O | 1932 | Ann J Cancer1932，，16： | 1 |
| 15 | The Expanding world of trinucleotide repeats显示文摘 | Tephen T | 1996 | Science1996，271，： | 1 |
| 16 | Finite element analysis of a single bead-on-plate specimen using SYSWELD 显示文摘 | Bate S K Charles R and Warren A | 2009 | International Journal of Pressure Vessels and Piping2009，，86： | 1 |
| 17 | Thecontribution of azo dyes to the mutagenic activity of theCristais River显示文摘 | Umbuzeiro G A Freeman H S Warren S H | 2005 | Chemosphere2005，60，： | 1 |
| 18 | Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells:implications for fracture healing显示文摘 | Bouletreau P J Warren S M Spector J A | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 19 | Stage c small cell carcinoma of the ovary;survial with conservative surgery and chemotherapy 显示文摘 | Rana S Warren BK Y amada SD | 2004 | Obstet Gynecol2004，103，6： | 1 |
| 20 | Mean value coordinates for closed triangular meshes 显示文摘 | Ju T Schaefer S Warren J | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
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