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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | Risk based voltage security assessment显示文摘 | Warn H McCalley J D Vittal V | 2000 | IEEE Transactions on Power Systems2000，15，4： | 1 |
| 3 | Estimation of the Nb-Ti-Ta phase diagram 显示文摘 | Li Na William H Warnes | 2001 | IEEE Trans Applied Superconductivity2001，11，1： | 1 |
| 4 | Plasma concentrations of arginine v asotocin and urotensin Ⅱ are reduced following transfer of the euryhaline flounder (Platichthys flesus) from seawater to fresh water显示文摘 | Winter MJ Warne JM | 2002 | Gen Comp Endocrinol2002，125，： | 1 |
| 5 | The freely expanding ring test-A test to determine material strength at high strain rates显示文摘 | Warnes R H Karpp R R Follansbee P S | 1985 | Journal De Physique IV1985，5，： | 1 |
| 6 | Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue 显示文摘 | Warne J P John C D Christian H C | 2006 | Am J Physiol Endocrinol Metab2006，291，6： | 1 |
| 7 | A generallised model of forest productivity using simplified concepts of radiation use efficiency, carbon balance and partitioning显示文摘 | Landsberg J J Warning R H | 1997 | Forest Ecology and Management1997，95，： | 1 |
| 8 | Comparison of the outcome of porcine bioprosthetic versus mechanical prosthetic replacement of the tricuspid valve in the Ebstein anomaly显示文摘 | Brown M L Dearani J A Danielson G K Cetta F Connolly H M Warnes C A | 2009 | Am J Cardiol2009，103，： | 1 |
| 9 | Distribution and partitioning of tracemetals (Cd, Cu, Ni, Pb, Zn) in Galveston Bay waters显示文摘 | Tang D Warn ken K W Santschi P H | 2002 | Marine Chemistry2002，78，： | 1 |
| 10 | Preimplantation development of in vitro-matured and in vitro-fertilized urine zygotes:comparison between eoculture on oviduct epithelial cell monolayers and culture under low oxygen atmosphere显示文摘 | WATSON A J WATSON P H WARNES D | 1994 | Biol Reprod1994，50，： | 1 |
| 11 | A combined analy- sis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombi- nant human follicle-stimulating hormone and human chorionic gonadotropin显示文摘 | Warne DW Decostcrd G Okada H | 2009 | Fertil Steril2009，92，： | 1 |
| 12 | Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans显示文摘 | Jung W H Warn P Ragni E Popolo L Nunn C D Turner M P | 2005 | Yeast2005，22，： | 1 |
| 13 | Acceleration of callus maturation using rhOP-1 in mandibular distraction osteogenesis in a rat model显示文摘 | Terheyden H Warn ke PH | | 0，，05： | 1 |
| 14 | Statistical properties of linear antenna impedance in an electrically large cavity显示文摘 | Warne L K Lee K S H Hudson H G | 2003 | IEEE Trans on Antennas and Propagation2003，51，5： | 1 |
| 15 | The nurse teacher in clinical practice: developing the new sub-di- mension to the Clinical Learning Environment and Su- pervision (CLES) Scale显示文摘 | Saarikoski M Isoaho H Warne T | 2008 | Int J Nurs Stud2008，45，8： | 1 |
| 16 | Biocidal efficacy of copper alloys against pathogenic enterococci involves degradation of genomic and plasmid DNAs显示文摘 | Warnes S Green S Michels H | 2010 | Appl Environ Microbiol2010，76，16： | 1 |
| 17 | Major complications of operative and diagnostic laparcoscopy for gynecologic disease 显示文摘 | Warn P H Lee W L Yuan C C | 2001 | JArn Aspic Cynecol Laparosc2001，8，1： | 1 |
| 18 | Numerical flow simulation of flush type intake duct of waterjet 显示文摘 | Warn G P Hyun S Y Ho H C | 2005 | Ocean Engineering2005，32，： | 1 |
| 19 | Numerical flow simulation of flush type intake duct of waterjet显示文摘 | WARN G HYUN S HO H | 2005 | Ocean Engineering2005，32，： | 1 |
| 20 | PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer ceils to mTOR inhibitory drugs 显示文摘 | Weigelt B Warne P H Downward J | 2011 | Oncogene2011，30，： | 1 |
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