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您的检索式：作者名="Wanwan Hong"
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| 1 | Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42显示文摘In many lower animals,germ cell formation,migration,and maintenance depend on maternally provided determinants in germ plasm.In zebrafish,these processes have been extensively studied in terms of RNA-binding proteins and other coding genes.The role of small non-coding RNAs in the regulation of primordial germ cell(PGC)development remains largely unknown and poorly investigated,even though growing interests for the importance of miRNAs involved in a wide variety of biological processes.Here,we reported the role and mechanism of the germ plasm-specific miRNA miR-202-5p in PGC migration:(i)both maternal loss and knockdown of miR-202-5p impaired PGC migration indicated by the mislocalization and reduced number of PGCs;(ii)cdc42se1 was a direct target gene of miR-202-5p,and overexpression of Cdc42se1 in PGCs caused PGC migration defects similar to those observed in loss of miR-202-5p mutants;(iii)Cdc42se1 not only interacted with Cdc42 but also inhibited cdc42 transcription,and overexpression of Cdc42 could rescue PGC migration defects in Cdc42se1 overexpressed embryos.Thus,miR-202-5p regulates PGC migration by directly targeting and repressing Cdc42se1 to protect the expression of Cdc42,which interacts with actin to direct PGC migration. | Yilin Jin Wei Liu Yangxi Xiang Wanwan Zhang Hong Zhang Kuntong Jia Meisheng Yi | 2020 | Journal of Molecular Cell Biology2020，12，7： | 2 |
| 2 | Hollow carbon microbox from acetylacetone as anode material for sodium-ion batteries显示文摘Carbon-based materials have attracted much interest as one of the promising anodes for sodium-ion batteries. However, low utilization of electrolyte and slow ion-transfer rate during electrochemical process hinder the further application of traditional bulk carbon. In order to enhance the diffusion kinetics and maintain the reversibility, hierarchical hollow carbon microbox was successfully prepared through a tunable bottom-up self-template routine for sodium-ion batteries. During annealing process, the morphology construction and activation happened synchronously. Based on that, a range of cross-linked porous nanosheet and hollow microbox were attained by manipulating reactant condition. The generation of texture and physical property are analyzed and are established linkages related to the electrochemical behavior. As results depicted in kinetic exploration and simulation based on cyclic voltammetry, the surfacecontrolled electrochemical behavior gradually turns to be the diffusion-controlled behavior as the hollow microbox evolves to porous nanosheet. The probable reason is that the rational microstructure/texture design leads to the accelerated diffusion kinetic procedure and the reduced concentration difference polarization. Sodium storage mechanism was deduced as reversible binding of Na-ions with local defects,including vacancies on sp2 graphitic layers, at the edges of flakes and other structural defects instead of intercalation. Bestowed by the morphology design, the broad pore width distribution, abundant defects/active sites and surface functionality, hollow microbox electrode delivers great electrochemical performances. This work is expected to propose a novel and effective strategy to prepare tunable hierarchical hollow carbon microbox and induce the fast kinetic of carbon anode material. | Tianyun Qiu Wanwan Hong Lin Li Yu Zhang Peng Cai Cheng Liu Jiayang Li Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 3 | Deeper Attention-Based Network for Structured Data显示文摘Deep learning methods are applied into structured data and in typical methods,low-order features are discarded after combining with high-order featuresfor prediction tasks.However,in structured data,ignorance of low-order features may cause the low prediction rate.To address this issue,in this paper,deeper attention-based network(DAN)is proposed.With DAN method,to keep both low-and high-order features,attention average pooling layer was utilized to aggregate features of each order.Furthermore,by shortcut connections from each layer to attention average pooling layer,DAN can be built extremely deep to obtain enough capacity.Experimental results show DAN has good performance and works effectively. | Xiaohua Wu Youping Fan Wanwan Peng Hong Pang Yu Luo | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
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