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| 1 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 2 | Detection of dynamic brain networks modulated by acupuncture using a graph theory model显示文摘Neuroimaging studies involving acute acupuncture manipulation have already demonstrated significant modulatory effects on wide limbic/paralimbic nuclei, subcortical gray structures and the neocortical system of the brain. Due to the sustained effect of acupuncture, however, knowledge on the organization of such large-scale cortical networks behind the active needle stimulation phase is lacking. In this study, we originally adopted a network model analysis from graph theory to evaluate the functional connectivity among multiple brain regions during the post-stimulus phase. Evidence from our findings clearly supported the existence of a large organized functional connectivity network related to acupuncture function in the resting brain. More importantly, acupuncture can change such a network into a functional state underlying both pain perception and modulation, which is exhibited by significant changes in the functional connectivity of some brain regions. This analysis may help us to better understand the long-lasting effects of acupuncture on brain function, as well as the potential benefits of clinical treatments. | Lijun Bai Wei Qin Jie Tian Jianping Dai Wanhai Yang | 2009 | Progress in Natural Science:Materials International2009，19，7： | 11 |
| 3 | Periurethral Injection of Autologous Adipose-Derived Stem Cells with Controlled-Release Nerve Growth Factor for the Treatment of Stress Urinary Incontinence in a Rat Model显示文摘 | Weiming Zhao Cheng Zhang Chengjun Jin Zijian Zhang Deling Kong Wanhai Xu Youcheng Xiu | 2010 | European Urology2010，，1： | 2 |
| 4 | An analysis and reflection on effective teaching显示文摘近半个世纪以来的“有效教学”研究存在诸多可疑之处,包括内涵界说的模糊、对立面的虚假以及教与学的失衡;研究中隐藏着深层思维障碍,如过分依赖技术理性的力量、推论的错误和教学辩证关系的割裂等。作为一种研究方向的调整,理想的教学应该以道德为核心而不是以效率为核心,同时兼顾有效性和责任。 | LIU Wanhai | 2008 | Frontiers of Education in China2008，3，1： | 2 |
| 5 | The Diversity of Soil Fauna Communities in the Karst Cave Wetland of Maolan Nature Reserve显示文摘From March 2014 to February 2015, the soil fauna community in the karst cave wetland of Maolan Nature Reserve was investigated. A total of 3,820 soil fauna was obtained, belonging to 31 orders, 11 classes, and 3 phyla. The dominant groups were Araneae, Coleoptera and Hymenoptera, accounting for 48.90% of the total catch. There were 18 common groups and 10 rare groups. The diversity analysis showed that the Banzhai karst cave wetland had the largest soil fauna community diversity index and evenness index and that the Dongsai karst cave wetland had the largest number of groups and individuals. The seasonal variation of the soil fauna in the karst cave wetlands was analyzed: the number of soil fauna individuals showed a downtrend in summer, autumn, spring and winter; there were the highest number of phytophagous soil fauna, followed by predatory soil fauna and saprophagous soil fauna. | LAN Hongbo RAN Jingcheng YAO Wuqing WANG Wanhai YAO Zhengming MENG Huili | 2018 | Journal of Landscape Research2018，10，6： | 2 |
| 6 | Arsenic Trioxide Increases the Sensitivity of 786–0 Renal Carcinoma Cells to Radiotherapy显示文摘 | Yu Su XiaoMin Wang WanHai Xu Li Xue ChunBo He DeJun Yang RuiHua An | 2012 | Cancer Investigation2012，，2： | 1 |
| 7 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 8 | Remote Sensing Image Fusion with Multi -Wavelet Trausform显示文摘 | Manfred Elders Wanhai Yang | | Proceediag of SPIE0，5574，： | 1 |
| 9 | Effects of Mg on the structures and cycling properties of the LaNi 3.8 hydrogen storage alloy for negative electrode in Ni/MH battery显示文摘 | Zhewen Ma Ding Zhu Chaoling Wu Chenglin Zhong Qiannan Wang Wanhai Zhou Linshan Luo Yucheng Wu Yungui Chen | 2015 | Journal of Alloys and Compounds2015，，： | 1 |
| 10 | Structural Strength Analysis of a Tri-Floater Floating Foundation for Offshore VAWT显示文摘Vertical axis wind turbines(VAWTs) are advantageous for the development of large-scale offshore wind power because the drive system is located at the bottom of the turbine. This study investigates the structural strength of a tri-floater floating foundation supporting a 2.6 MW Darrieus VAWT. Finite element models of the floating foundation were developed using space plate-beam elements. The environmental loads, such as the aerodynamic loads, static wind loads, and wave-current loads, were considered. The general strengths of the floating foundation were calculated for the normal operating case(a cut-out wind speed of 25 m s^(-1) and blade rotation of 12 r min^(-1) were used to analyze the most unfavorable loads) and an extreme case(wind speed of 40 m s^(-1) and parked blades), and the weak components of the structure were analyzed. The results show that the floating foundation meets the strength requirements and the structural stress is highest when the wave, wind, and current are in a collinear direction. The main and secondary supporting bars transmit the loads between the stand columns and the tower foundation, and their stresses are higher than those in the other components. In the actual design, these supporting bars should be strengthened. The aerodynamic loads are very important and should be considered in the structural strength analysis of the floating foundation and the floating wind turbine system. | LIU Liqin ZHAO Haixiang XU Wanhai YUAN Rui GUO Ying | 2018 | Journal of Ocean University of China2018，17，4： | 1 |
| 11 | Redox Mediator Chemistry Regulated Aqueous Batteries:Insights into Mechanisms and Prospects显示文摘Redox mediators(RMs),serving as intermediate electron carriers or reservoirs,play vital roles in developing new charge transfer energy storage systems with high voltage or capacity in aqueous batteries.However,the underlying mechanism and selection criteria of RMs remain unclear in aqueous batteries,which hinders the further exploitation of new RMs and aqueous battery chemistries. | Tengsheng Zhang Qianru Chen Xinran Li Jiahao Liu Wanhai Zhou Boya Wang Zaiwang Zhao Wei Li Dongliang Chao Dongyuan Zhao | 2022 | CCS Chemistry2022，4，9： | 1 |
| 12 | DECISION FUSION FOR WIRELESS SENSOR NETWORKS UNDER NAKAGAMI FADING CHANNELS显示文摘Decision fusion rules for Wireless Sensor Networks (WSNs) under Nakagami fading channels are investigated in this paper. Considering the application limitation of Likelihood Ratio Test fusion rule based on information of Channel Statistics using Series expansion (LRT-CSS),and the detection performance limitation of the Censoring based Mixed Fusion rule (CMF),a new LRT fusion rule based on information of channel statistics has been presented using Laplace approximation (LRT-CSL). Theoretical analysis and simulations show that the proposed fusion rule provides better detection performance than the Censoring based Mixed Fusion (CMF) and LRT-CSS fusion rules. Furthermore,compared with LRT-CSS fusion rule,the proposed fusion rule expands the application range of likelihood ratio test fusion rule. | Yuan Xiaoguang Yang Wanhai Shi Lin | 2010 | Journal of Electronics(China)2010，27，2： | 0 |
| 13 | Boosting image-guiding radiation therapy through W_(18)O_(49) nanospheres and the second near-infrared light irradiation显示文摘More than 60%of cancer patients receive radiation therapy(RT)during their anticancer treatment.However,there is a huge challenge to improve the therapeutic efficacy of RT in less radioresponsive tumors and decrease damages dealt to the surrounding healthy tissues.Herein,we have reported the development of an efficacious RT treatment of relatively radio-resistant breast cancer using W_(18)O_(49)nanospheres and the second near-infrared(NIR)light irradiation.Featuring the X-ray attenuation ability and photothermal effect,together with ability to generate intracellular singlet oxygen and·OH,W_(18)O_(49)nanospheres can significantly increase radiation-induced DNA damage and decrease the mitochondrial membrane potential of cancer cells during RT,causing in nearby three-times improvement in inhibiting the proliferation of 4T1 cells.The in vivo evaluations verify that a rather effective therapeutic outcome is achieved by treatment of 4T1 tumor xenograft with NIR-enhanced RT using W_(18)O_(49)nanospheres.Moreover,the X-ray attenuation ability and the strong near-infrared absorption of W_(18)O_(49)nanospheres have enabled highly resolved in vivo computer tomography(CT)/photoacoustic(PA)imaging.This work presents an“all-in-one”synergistic platform to improve the therapeutic efficacy of RT in less radioresponsive tumors,therefore opening a new door for multimodal cancer therapy. | Nannan Zheng Shouhao Zhang Lu Wang Zhilin Qi Qiang Peng Lingrui Jian Yang Bai Yue Feng Jiachen Shen Ranxu Wang Jia Jiao Wanhai Xu Shaoqin Liu | 2022 | Nano Research2022，15，3： | 0 |
| 14 | Cathodic electrolyte engineering toward durable Zn-Mn aqueous batteries显示文摘Zn-Mn aqueous batteries(ZMABs)present potential for grid-scale energy storage with the benefits of low cost,high safety and eco-friendliness[1].Since 1866(Leclanchéwet cell),we have witnessed the prosperity of ZMABs in the primary battery market and an increasing interest in rechargeable ZMABs. | Wanhai Zhou Hong Jin Fan Dongyuan Zhao Dongliang Chao | 2023 | National Science Review2023，10，12： | 0 |
| 15 | Clinical practice guideline on bladder cancer(PartⅡ)显示文摘Bladder cancer(BC)is an increasingly common malignancy in China,with an incidence rate of 5.80 per 100000 in 2015,making it the thirteenth most common cancer in the country.This trend underscores the urgent need for standardized diagnosis and treatment protocols.In terms of treatment,approaches for bladder cancer vary based on the cancer's stage and pathology,as well as the patient's overall health.Notably,non-muscleinvasive BC(NMIBC)confined to the mucosa(Ta)and lamina propria(T1)without invading the muscle represents about 75%of all BC cases.Succeeding the first part of the guideline,this part of the clinical practice guideline focuses on NMIBC.It details risk classifications and treatment options,including both surgical procedures and posttransurethral resection of the bladder tumor intravesical instillations.Special attention is given to the treatment strategies for carcinoma in situ.The guideline also covers the recommended follow-up procedures for patients with NMIBC,underscoring the need for thorough and continuous care management. | Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng Yulin Liu Min Liu Zhigang Ji Xiao Li Jiongming Li Yong Zhang Fangjian Zhou Aiping Zhou Wanhai Xu Tao Xu Xianshu Gao Qing Zhai Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，3： | 0 |
| 16 | Clinical practice guideline on bladder cancer(Part Ⅲ)显示文摘Bladder cancer(BC)has become a significantly prevalent disease in China,with an incidence rate of 5.80 per 100000 in 2015,ranking it as the thirteenth most common type of cancer within the nation.This illness presents a serious public health concern,highlighting the imperative need to unify the standards for diagnosis and treatment to improve patient outcomes.The section of the clinical practice guideline in question is dedicated to addressing muscle-invasive bladder cancer(MIBC)and metastatic BC.The primary treatment strategies for MIBC are well-defined:preoperative(neoadjuvant)chemotherapy combined with radical cystectomy stands as the conventional treatment protocol.For patients with locally advanced MIBC,integrating systemic and local therapies is advocated to enhance treatment effectiveness.In cases of metastatic BC,the focus shifts to systemic treatment supplemented by supportive care measures.The guideline also succinctly presents the pros and cons of various urinary diversion surgeries,which are critical considerations following radical cystectomy.It provides an in-depth exploration of the treatment modalities for metastatic urothelial carcinoma of the bladder.Additionally,this part delves into the integrated approach to treatment and the use of radiotherapy in bladder preservation for localized disease.Moreover,it offers a concise overview of the classification,diagnosis,and therapeutic approaches for nonurothelial carcinoma of the bladder.Lastly,this part emphasizes the importance of recommended posttreatment follow-up for MIBC patients to ensure comprehensive and ongoing care management. | Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng Yulin Liu Min Liu Zhigang Ji Xiao Li Jiongming Li Yong Zhang Fangjian Zhou Aiping Zhou Wanhai Xu Tao Xu Xianshu Gao Qing Zhai Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，4： | 0 |
| 17 | Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway显示文摘Although the functional parameters of micro RNAs(mi RNAs)have been explored to some extent,the roles of these molecules in coronavirus infection and the regulatory mechanism of mi RNAs in virus infection are still unclear.Transmissible gastroenteritis virus(TGEV)is an enteropathgenic coronavirus and causes high morbidity and mortality in suckling piglets.Here,we demonstrated that microRNA-27b-3p(miR-27b-3p)suppressed TGEV replication by directly targeting porcine suppressor of cytokine signaling 6(SOCS6),while TGEV infection downregulated miR-27b-3p expression in swine testicular(ST)cells and in piglets.Mechanistically,the decrease of miR-27b-3p expression during TGEV infection was mediated by the activated inositolrequiring enzyme 1(IRE1)pathway of the endoplasmic reticulum(ER)stress.Further studies showed that when ER stress was induced by TGEV,IRE1 acted as an RNase activated by autophosphorylation and unconventionally spliced m RNA encoding a potent transcription factor,X-box-binding protein 1(Xbp1s).Xbp1s inhibited the transcription of miR-27 and ultimately reduced the production of miR-27b-3p.Therefore,our findings indicate that TGEV inhibits the expression of an anti-coronavirus micro RNA through the IRE1 pathway and suggest a novel way in which coronavirus regulates the host cell response to infection. | Changlin Wang Mei Xue Peng Wu Honglei Wang Zhongqing Liu Guangzheng Wu Pinghuang Liu Keliang Wang Wanhai Xu Li Feng | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 18 | Clinical practice guideline on bladder cancer(Part Ⅰ)显示文摘Bladder cancer represents one of the most prevalent malignant tumors affecting the urinary system.As per data disclosed by the National Cancer Registration Center of China in 2019,the incidence of bladder cancer was 5.80 per 100,000 in 2015,placing it as the thirteenth most common systemic malignancy.Bladder cancer poses a substantial threat to public health in China,underlining the critical importance of standardizing diagnosis and treatment to enhance clinical outcomes.This clinical practice guideline for bladder cancer centers on the etiologies,clinical presentations,and diagnostic procedures for suspected bladder cancer,in addition to the histopathology and staging of urothelial bladder cancer. | Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng Yulin Liu Min Liu Zhigang Ji Xiao Li Jiongming Li Yong Zhang Fangjian Zhou Aiping Zhou Wanhai Xu Tao Xu Xianshu Gao Qing Zhai Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，1： | 0 |
| 19 | Consensus on safety management of novel hormonal therapy for advanced prostate cancer显示文摘Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical benefits.However,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of life.In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients.Additionally,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management. | Sujun Han Shudong Cheng Degang Ding Jianming Guo Zhisong He Baiye Jin Zhigang Ji Tianxin Lin Yuanjie Niu Weijun Qin Benkang Shi Jinkai Shao Xi'nan Sheng Qiang Wei Xin Wang Xinghuan Wang Shujie Xia Wanhai Xu Qing Zou Xiongbing Zu Renu Eapen Chi‐Fai Ng Hirotsugu Uemura Hiroji Uemura Cheol Kwak Jae Young Joung Marniza Saad Edmund Chiong Nianzeng Xing | 2023 | UroPrecision2023，1，2： | 0 |
| 20 | An activated excretion-retarded tumor imaging strategy towards metabolic organs显示文摘Intraoperative fluorescence-based tumor imaging plays a crucial role in performing the oncological safe tumor resection with the advantage of differentiating tumor from normal tissues.However,the application of these fluorescence contrast agents in renal cell carcinoma(RCC)and hepatocellular carcinoma(HCC)was dramatically hammered as a result of lacking active targeting and poor retention time in tumor,which limited the Signal to Noise Ratio(SNR)and narrowed the imaging window for complicated surgery.Herein,we reported an activated excretion-retarded tumor imaging(AERTI)strategy,which could be in situ activated with MMP-2 and self-assembled on the surface of tumor cells,thereby resulting in a promoted excretion-retarded effect with an extended tumor retention time and enhanced SNR.Briefly,the AERTI strategy could selectively recognize the Integrin α_(v)β_(3).Afterwards,the AERTI strategy would be activated and in situ assembled into nanofibrillar structure after specifically cleaved by MMP-2 upregulated in a variety of human tumors.We demonstrated that the AERTI strategy was successfully accumulated at the tumor sites in the 786-O and HepG2 xenograft models.More importantly,the modified modular design strategy obviously enhanced the SNR of AERTI strategy in the imaging of orthotopic RCC and HCC.Taken together,the results presented here undoubtedly confirmed the design and advantage of this AERTI strategy for the imaging of tumors in metabolic organs. | Da-Yong Hou Man-Di Wang Xing-Jie Hu Zhi-Jia Wang Ni-Yuan Zhang Gan-Tian Lv Jia-Qi Wang Xiu-Hai Wu Lu Wang Hao Wang Wanhai Xu | 2022 | Bioactive Materials2022，7，8： | 0 |
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