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| 1 | Oral uptake and persistence of the FnAb-8 protein characterized by in situ radio-labeling and PET/CT imaging显示文摘The absorption of peptides and proteins delivered orally is minimum because of the intestine epithelial barrier.There are few known active transport mechanisms for macromolecules including the neonatal Fc Receptor(FcRn)for the absorption and secretion of IgGs in infant and adult intestine.We had previously described the FnAb-8 protein that could bind to h FcRn tightly at pH 6.0 but barely at pH 7.4.In this study,we examined its uptake,biodistribution and pharmacokinetics after peroral administration in both wild-type and human FcRn transgenic(Tg)mice.FnAb-8 was modified to contain trans-cyclooctene(TCO)which could interact with18 F labeled tetrazine in situ via the bioorthogonal inverseelectron-demand Diels-Alder reaction.We showed that FnAb-8 had a tendency to distribute and persist in the Tg mice intestine for an extended duration of time.It could also be absorbed into the circulation and distributed systemically over a long period of time up to 172 h.The improvement in oral uptake and concentration in the intestine tissue may be valuable for designing oral delivery of biopharmaceuticals,especially for diseases involving the gastric intestinal tissue. | Qian Wang Wangxi Hai Sanyuan Shi Jinliang Peng Yuhong Xu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 2 | Effect of Different Irrigation Patterns on Transportation and Allocation of Carbohydrate During Grain Filling of Rice显示文摘Using intersubspecific hybrid rice Xieyou 9308 and Liangyou Peijiu as the tested materials, the effects of differentirrigation patterns on transportation and allocation of carbohydrate during grain filling stage was observed by the designwith three level of soil water content in irrigated field. The results showed that in the conventional flooding and thealternate dry-watering cultivations, the exported rate of stored carbohydrate from stem and photophate from the leaves were60 and 90 % respectively. The exported rate of carbohydrate was decreased significantly (P<0.01) in the non-floodingcultivation. There was no significant difference between the conventional flooding and dry-wet alternation treatments interm of the exported rate of carbohydrate. The filling grains were the major sinks for carbohydrate storage during grainfilling stage. Grains received nearly 50% of stored carbohydrate from leaf sheath and 80% of photophate from leaves. Atthe nonflooding condition the absorbing rates of grains were significantly decreased by 10 % from leaf sheath and 20 %from leaves photophate. Water stress leaded much decrease in absorbing ability for inferior grains, which might be one ofthe main causes for low seed-settling rate in non-flooding cultivation. | CHENHai-sheng TAOLong-xing WANGXi HUANGXiao-lin TANHui-juan CHENGShi-hua MINShao-kai | 2005 | Agricultural Sciences in China2005，4，3： | 2 |
| 3 | Second-orderoptimalityconditionsinset-valuedoptimizationproblems[J]显示文摘 | WangXY ZhuSK PengXY | | 四川大学学报:自然科学版0，，： | 2 |
| 4 | Effects of curcumin concentration and temperature on the spec- troscopic properties of liposomal curcumin显示文摘 | NIU Y M WANGXY CHAIS H | 2012 | Journal of Agricultural and Food Chemistry2012，60，： | 1 |
| 5 | Manufacture of carbon fiber from polyacrylonitrile precursors treated with COSO4 显示文摘 | Zhang Wangxi Wang Yanzhi | 2002 | Journal of applied polymer science2002，85，1： | 1 |
| 6 | Studiesonteaproteinextractionusingalkalineandenzymemethods显示文摘 | ShenLQ WangXY WangZY etal | 2008 | FoodChemistry2008，107，2： | 1 |
| 7 | On regulation technology of bend branching shoal in mountain river显示文摘 | LIU Wangxi TAN Kun YANG Xiangfei | 2011 | Journal of Chongqing Jiaotong University(Natural Science)2011，30，3： | 1 |
| 8 | Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration显示文摘Layer-by-layer assembly is a versatile technique for fabricating nanofiltration membranes,where multiple layers of polyelectrolytes are usually required to achieve reasonable separation performance.In this work,an ionic strength directed self-assembly procedure is described for the preparation of nanofiltration membranes consisting of only a single bilayer of poly(diallyldimethylammoniumchloride)and poly(sodium-4-styrenesulfoate).The influence of background ionic strength as well as membrane substrate properties on the formation of singlebilayer membranes are systematically evaluated.Such a simplified polyelectrolyte deposition procedure results in membranes having outstanding separation performance with permeating flux of 14.21.5 L∙m^(–2)∙h^(-1)∙bar^(–1) and Na2SO4 rejection of 97.1%0.8%under a low applied pressure of 1 bar.These results surpass the ones for conventional multilayered polyelectrolyte membranes.This work encompasses an investigation of ionic strength induced coiling of the polyelectrolyte chains and emphasizes the interplay between-polyelectrolyte chain configuration and substrate pore profile.It thus introduces a new concept on the control of membrane fabrication process toward high performance nanofiltration. | Feng Zhang Lu Tan Li Gong Shuqi Liu Wangxi Fang Zhenggong Wang Shoujian Gao Jian Jin | 2022 | Frontiers of Chemical Science and Engineering2022，16，5： | 1 |
| 9 | Evolution of structure and properties of PAN precursors during their conversion to carbon fibers 显示文摘 | Zhang Wangxi Liu Jie Wu Gang | 2003 | Carbon2003，41，： | 1 |
| 10 | A Summary of the Forum on Language Learning Theory——Editing Board of Chinese Teaching in the World Editing Board of Applied Linguistics Editing Board of Language Teaching and Linguistic Studies显示文摘1. Participants Initiated by Lü Bisong from Beijing Language Institute and sponsored by the Editing Boardsof Chinese Teaching in the World, Applied Linguistics, and Language Teaching and LinguisticStudies, a forum on language learning theory was held from May 14 to 18, 1992 in Beijing, in or-der to push forward China’s research in language teaching theories and language teaching method-ology. The suggested areas for discussion at the Forum included: 1. the scope of research in lan-guage learning theory; 2. significance of these theories for language teaching; 3. relation and dif-ference between 'learning' and 'acquisition' ; 4. similarities and differences between L1 and L2learning; 5. relation between spoken language and written language; 6. research methods in lan-guage learning theory; 7. the state of the art of this research in other countries; 8. the state ofthe art in China; 9. direction and focus in China’s research in the field;10. the future of this re- | Zhang Wangxi, Liu Runqing | 1992 | 世界汉语教学1992，6，4： | 1 |
| 11 | Solution to the lateral displacement of lateral loaded long-piles under double-parameter layered-foundation显示文摘 | Zhang Wangxi Zhan Xinjie Yi Weijian | 2011 | Journal of Hunan University(Natural Sciences)2011，38，3： | 1 |
| 12 | Areviewofthemanagementofthoracolumbarburstfractures显示文摘 | DaiLY JiangSD WangXY JiangLS | 2007 | SurgNeurol2007，67，22： | 1 |
| 13 | Composition and ecological distribution of cry proteins and their genotypes of Bacillus thuringiensis isolates from warehouses in China 显示文摘 | Ziniu Y Wangxi D | 2000 | J Invertebr Pathol2000，76，3： | 1 |
| 14 | Expression and significance of human telomerase reverse transcriptase mRNA in laryngeal squamous cell cancer and its relationship with c-myc显示文摘 | Gu DH WangXY TangF | 2006 | FuDan Univ J Med Sci2006，33，4： | 1 |
| 15 | Evolotion of structure and properties of PAN precursors during their conversion to carbon fibers显示文摘 | Zhang Wangxi Liu Jie Wu Gang | 2003 | Carbon2003，41，14： | 1 |
| 16 | Different medicine turmeric extracts of the stabilizing effect of curcumin [J]显示文摘 | HANG WANGXY WANGYN etal | | 中国中药杂志0，32，9： | 1 |
| 17 | Analysis of sym metric or partially symmetric structures显示文摘 | Wangxie ZHONG Chunhang QIU | 1983 | Computer methods in applied mechanics and engineering1983，，1： | 1 |
| 18 | Evolution of structure and properties of PAN precursors during their conversion to carbon fibers显示文摘 | Zhang Wangxi Liu Jie Wu Gang | 2003 | Carbon2003，，14： | 1 |
| 19 | ComPosite for-ward osmosis hollow fiber membranes:Integration ofRO-and NF-like selective layers for enhanced organicfouling resistance显示文摘 | Fang Wangxi Liu Chang Shi Lei | 2015 | J Membr Sci2015，492，： | 1 |
| 20 | Regulationeffectsofnitrogenapplicationonthepoly-aminemetabolismandsenescenceofpeanutleaves显示文摘 | WangXY(王晓云) LiXD(李向东) ZouQ(邹琦) | | 作物学报0，，： | 1 |
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