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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 3 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 4 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 5 | Studies on processing, particle formation and immunogenicity of the HIV-1gag gene product: A possible component of a HIV vaccine显示文摘 | Wagner R Fliessbach H Wanner G | 1992 | Arch Virol1992，127，14： | 2 |
| 6 | the barrier discharge:basic properties and applications to surface treatment显示文摘 | Wagner H E brandenburg R Kozlov K V | 2003 | Vacuum2003，71，3： | 2 |
| 7 | Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model显示文摘 | Vogelmann R Ruf D Wagner M | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，1： | 1 |
| 8 | Understanding patent - quality mechanisms 显示文摘 | R POLK WAGNER | 2009 | University of Pennsylvania Law Review2009，，157： | 1 |
| 9 | Electrophoretic, solubility, and functional properties of commercial soy protein isolartes 显示文摘 | Arrese E L Sorgentini D A Wagner J R Anon M C | 1991 | Journal of Agricultural and Food Chemistry1991，39，： | 1 |
| 10 | Induction of collagenase and stromelysin gene expression by mechanic injury in vascular smooth - derived cell Line显示文摘 | James T W Wagner R White L A | 1993 | J cell physiol1993，157，： | 1 |
| 11 | The identification of two myoinhibitory peptides, with sequence similarities to the galanins,isolated from the ventral nerve cord of Manduca Sexta显示文摘 | BLACKBURN M B WAGNER R M KOCHANSKY J P | 1995 | Regul Pept1995，57，3： | 1 |
| 12 | Acceptable practices in Ontario's forests: differences between the public and forestry professionals显示文摘 | WAGNER R G FLYNN J GREGORY R | 1998 | New For1998，16，： | 1 |
| 13 | Thermal and electrophoretic behavior,hydrophobicity,and some functional properties of acid-treated soy isolates显示文摘 | Wagner J R Sorgentini D A Anon M C | 1996 | J Agri Food Chem1996，44，： | 1 |
| 14 | Effect of combined use of nonionic surfactant on formation of oil-in-water mlcroemulsions显示文摘 | Li P Ghosh A Wagner R F | 2005 | Int J Pharm2005，288，1： | 1 |
| 15 | Nanoscale shear and indentation measurement in tran-scrystallineα-isotacitc polypropylene显示文摘 | Amitay-Sadovsky E Cohen S R Wagner H D | 2001 | Macro-molecules2001，34，： | 1 |
| 16 | Malignant intestinalnon-Hodgkin’lymphoma from the surgical point of view 显示文摘 | Samel S Wagner J Hofheinz R | 2002 | Onkol-ogie2002，25，3： | 1 |
| 17 | A New Equation of State for H20 Ice IH 显示文摘 | FEISTEL R WAGNER W | 2006 | Journal of Physical and Chemical Reference Data2006，35，2： | 1 |
| 18 | Statistics of speckle in ultrasound B-scans 显示文摘 | Wagner R F Smith S W Sandrik J M | 1983 | IEEE Transactions on Sonics and Ultrasonics1983，30，3： | 1 |
| 19 | Soluble urokinase plasminogen activator receptor predicts mortality in patients with systemic inflammatory response syndrome显示文摘 | Raggam R B Wagner J Pruller F | 2014 | J Intern Med2014，276，6： | 1 |
| 20 | Geographic structure of chloroplast DNA polymorphisms in European oaks 显示文摘 | Petit R Kremar A Wagner D | 1993 | Theoretical and Applied Genetics1993，87，： | 1 |
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