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| 1 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 2 | Quantification of three di mensional vertebral rotation in scoliosis: What are the true values? 显示文摘 | Wafa S Francois L Jean LD | 1995 | Spine1995，20，7： | 1 |
| 3 | Shear behavior of high-strength fiber reinforced concrete beams 显示文摘 | ASHOUR S A HASANAIN G S WAFA F F | 1992 | ACI Struct J1992，89，2： | 1 |
| 4 | Formal concept analysis based association rules extraction显示文摘 | Ourida B B S Wafa T | 2011 | International Journal of Computer Science Issues2011，8，4： | 1 |
| 5 | Mechanical properties of high-strength fiber reinforced concrete显示文摘 | WAFA F F ASHOUR S A | 1992 | ACI Materials Journal1992，89，5： | 1 |
| 6 | Flexural behavior of high-strength fiber reinforced concrete beams 显示文摘 | ASHOUR S A WAFA F F | 1993 | ACI Struct J1993，90，3： | 1 |
| 7 | Shear behavior of high-strength fiber reinforced concrete beams 显示文摘 | ASHOUR S A HASANAIN G S WAFA F F | 1992 | ACI Struct J1992，89，2： | 1 |
| 8 | Shear behavior of high-strength fiber reinforced concrete beams显示文摘 | ASHOUR S A HASANAIN G S WAFA F F | 1992 | ACI Structural Journal1992，86，2： | 1 |
| 9 | Shear behaviour of high-strength fiber- reinforced concrete beams显示文摘 | Ashour S A Hasanain G S Wafa F F | 1992 | ACI Structural Journal1992，89，2： | 1 |
| 10 | Vertebral wedging characteristic changes in scoliotic spines显示文摘 | Stefan P Hubert L Wafa S | 2004 | Spine2004，29，： | 1 |
| 11 | A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting af- ter laparoscopic surgery显示文摘 | Islam M Wafa A Asma S | 2009 | Saudi Med J2009，30，12： | 1 |
| 12 | On the nesting habit of Andrena ovatula: K显示文摘 | WAFA AK RASHAD S MOUSTAFA MA | 1972 | Egypt Dtsch Ent Z1972，19，： | 1 |
| 13 | Shear behavior of high-strength fiber reinforced concrete beams 显示文摘 | ASHOUR S A HASANAIN G I S WAFA F F | 1992 | ACI Structural Journal1992，89，2： | 1 |
| 14 | Supply chain optimization of petroleum organization under uncertainty in market demands and prices显示文摘 | WAFA B E HAITHAM A O LABABIDI M S | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 15 | Flexural Behavior of High-strength Fiber Reinforced Concrete Beams 显示文摘 | ASHOUR S A WAFA F F | 1993 | ACI Structural Journal1993，90，3： | 1 |
| 16 | A biomechanical analysis of short segment spinal fixation using a there-dimensional geometric and mechanical model显示文摘 | Wafa S Stephane R Francois L | 1993 | Spine1993，18，5： | 1 |
| 17 | Mechanical properties of highstrength fiber reinforced concrete显示文摘 | WAFA F F ASHOUR S A | 1992 | ACI Materials Journal1992，89，5： | 1 |
| 18 | Effect of the Con-crete Compressive Strength and Tensile Reinforcement Ratio on the Flexural Behavior of Fibrous Concrete显示文摘 | S A Ashour F F Wafa M I Kamal | 2000 | Engineering Structure2000，22，9： | 1 |
| 19 | Mechanical properties of high-strength fiber reinforced concrete显示文摘 | WAFA F F ASHOUR S A | | 0，，05： | 1 |
| 20 | Fast accurate stereoradiographic 3D-reconstruction of the spine using a combined geometric and statistic model显示文摘 | Vincent Pomero David Mitton Sébastien Laporte Jacques A de Guise Wafa Skalli | 2003 | Clinical Biomechanics2003，，3： | 1 |
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