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| 1 | Epalrestat improves motor symptoms by reducing oxidative stress and inflammation in the reserpine induced mouse model of Parkinson’s disease显示文摘Background:Parkinson's disease(PD)is a progressive neurodegenerative disorder affecting a large number of elderly people worldwide.The current therapies for PD are symptom-based;they do not provide a cure but improve the quality of life.Muscular dysfunction is the hallmark clinical feature of PD and oxidative stress and inflammation play a critical role in its pathogenesis.Epalrestat is used for the treatment of diabetic neuropathy and is known to improve antioxidative defense mechanisms in the CNS.Therefore,in this study,we investigated the role of Epalrestat in the reserpine induced mouse model of PD.Method:We used Swiss Albino mice for the PD model and tested for akinesia/bradykinesia,muscular rigidity,palpebral ptosis,and tremor,as well as conducting swim and open field tests.Brain samples were used to determine oxidative stress parameters and infiltration of immune cells.Results:Epalrestat treatment significantly improved akinesia and bradykinesia,muscular dysfunctions,tremor level,and gait functions compared to the reserpine group.It also improved the latency in the swim test.Eplarestat significantly reduced lipid peroxidation and NO concentration in different brain tissues and increased the activity of antioxidative enzymes,glutathione,catalase,and superoxide dismutase.Furthermore,Epalrestat reduced neuroinflammation by reducing the number of infiltrating immune cells.Conclusion:Eplarestat improves muscular dysfunction in PD by reducing oxidative stress and inflammation. | Md.Mahbubur Rahman Rupali Rani Chakraborti Md.Abdullah Potol Ariful Haque Abir Ozayra Sharmin Mahabub Alam Md.Fazlur Rahman Khan Rownock Afrin Humayra Jannat Rasiqh Wadud Zaki Farhad Habib | 2020 | Animal Models and Experimental Medicine2020，3，1： | 3 |
| 2 | Development of microsatellite markers from an ectomycorrhizal fungus, Laccaria amethystina, by a dual-suppression-PCR technique显示文摘 | Wadud MA Lian CL Nara K | 2006 | Molecular Ecology Notes2006，6，1： | 1 |
| 3 | A dynamic histogram equalization for image contrast enhancement显示文摘 | WADUD M A A KABIR M H | 2007 | IEEE Transactions on Consumer Electronics2007，53，2： | 1 |
| 4 | Biosynthesis of methionine from homocysteine,cystathionine and homoserine plus cysteine by mixed rumen microorganisms in vitro显示文摘 | Or-Rashid M M Onodera R Wadud S | | 0，，06： | 1 |
| 5 | Farmhousehold efficiency in bangladesh:a comparison of stochastic frontier and DEA methods显示文摘 | Abdul Wadud and Ben White | 2000 | Applied economics2000，32，： | 1 |
| 6 | The frequency of postduralpuncture headache in different age groups 显示文摘 | Wadud R Laiq N Qureshi FA | 2006 | J Coll PhysiciansSurg Pak2006，16，： | 1 |
| 7 | Deep-BERT:Transfer Learning for Classifying Multilingual Offensive Texts on Social Media显示文摘Offensive messages on social media,have recently been frequently used to harass and criticize people.In recent studies,many promising algorithms have been developed to identify offensive texts.Most algorithms analyze text in a unidirectional manner,where a bidirectional method can maximize performance results and capture semantic and contextual information in sentences.In addition,there are many separate models for identifying offensive texts based on monolin-gual and multilingual,but there are a few models that can detect both monolingual and multilingual-based offensive texts.In this study,a detection system has been developed for both monolingual and multilingual offensive texts by combining deep convolutional neural network and bidirectional encoder representations from transformers(Deep-BERT)to identify offensive posts on social media that are used to harass others.This paper explores a variety of ways to deal with multilin-gualism,including collaborative multilingual and translation-based approaches.Then,the Deep-BERT is tested on the Bengali and English datasets,including the different bidirectional encoder representations from transformers(BERT)pre-trained word-embedding techniques,and found that the proposed Deep-BERT’s efficacy outperformed all existing offensive text classification algorithms reaching an accuracy of 91.83%.The proposed model is a state-of-the-art model that can classify both monolingual-based and multilingual-based offensive texts. | Md.Anwar Hussen Wadud M.F.Mridha Jungpil Shin Kamruddin Nur Aloke Kumar Saha | 2023 | Computer Systems Science & Engineering2023，44，2： | 1 |
| 8 | Farm household efficiency in ban- gladesh: a comparison of stochastic frontier and DEA meth- ods显示文摘 | WADUD A WH1TE B | 2000 | Appl Econ2000，32，： | 1 |
| 9 | Comparison of post amputation outcome in patients with type 2 dia-betes from specialized foot care centres in three develop-ing countries显示文摘 | Viswanathan V Wadud JR Madhavan S | 2010 | Diabetes Res Clin Pract2010，88，2： | 1 |
| 10 | Modeling and forecasting natural gas demand in Bangladesh显示文摘 | Zia Wadud Himadri S. Dey Md. Ashfanoor Kabir Shahidul I. Khan | 2011 | Energy Policy2011，，11： | 1 |
| 11 | Modelling fuel demand for different socio-economic groups显示文摘 | Zia Wadud Daniel J. Graham Robert B. Noland | 2009 | Applied Energy2009，，： | 1 |
| 12 | From household efficiency in Bangladesh: a comparison of stochastic frontier and DEA显示文摘 | Wadud Abdul and Ben White | 2000 | Applied Economics2000，，32： | 1 |
| 13 | Determination of histidine and related compounds in rumen fluid by liquid chro- matography 显示文摘 | Wadud S Onodera R Or-Rashid MM | 2000 | J AOAC Int2000，83，1： | 1 |
| 14 | Comparison of post amputation outcome in patients with type 2 diabetes from specialized foot care centres in three developing countries 显示文摘 | Viswanathan V Wadud JR Madhavan S | 2010 | Diabetes Res Clin Pract2010，88，2： | 1 |
| 15 | Ascorbic acid andα-tocopherol downregulate apolipoprotein A-I gene expression in Hep G2 and Caco-2 cell lines显示文摘 | MOORADIAN A D HAAS M J WADUD K | 2006 | Metabolism Clinical and Experimental2006，55，2： | 1 |
| 16 | A Skin Detection Approach Based on the Dempster - Shafer Theory of Evidence 显示文摘 | Shoyaib M Abdullah - A1 - Wadud M Chae O | 2012 | International Journal of Ap- proximate Reasoning2012，53，4： | 1 |
| 17 | Personal tradable carbon permits for road transport: Why, why not and who wins?显示文摘 | Wadud Z | 2011 | Transportation Research Part A: Policy and Practice2011，45，10： | 1 |
| 18 | Farm household efficiency inBangladesh:a comparison of stochastic frontier and DEA methods显示文摘 | WADUD WHITE | 2000 | Applied Economics2000，，32： | 1 |
| 19 | Farm household efficiency in Bangladesh:a comparison of stochastic frontier and DEA methods显示文摘 | Wadud A White B | 2000 | Applied Economics2000，32，13： | 1 |
| 20 | Evaluation of immunomagnetie separation in combination with ALOA Listeria chromogenie agar for the isolation and identification of Listeria monocytogenes in ready-to-eat foods显示文摘 | Wadud S Leon-Velarde C G Larson N | 2010 | Journal of Microbiological Methods2010，81，2： | 1 |
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