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| 1 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 2 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of o- verweight and obese patients 显示文摘 | Wysocka E Cofla S Cymerys M | 2008 | Physiol Pharmacol2008，59，6： | 1 |
| 3 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，59，： | 1 |
| 4 | Role of IL 12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL 10 and nitricoxide显示文摘 | Gazzinelli RT Hayashi S Wysocka M | | 0，，05： | 1 |
| 5 | Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii显示文摘 | Gazzinelli R T Wysocka M Hayashi S | 1994 | The Journal of Immunology1994，153，6： | 1 |
| 6 | Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis显示文摘 | Wysocka M Montaner LJ Karp CL | | 0，，11： | 1 |
| 7 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients 显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，596，： | 1 |
| 8 | Daily EV cone-beam CT and deformable image registration as a method for studying dosimetric consequences of anatomic changes in adaptive IMRT of head and neck cancer 显示文摘 | Elstrφm UV Wysocka BA Muren LP | 2010 | Acta Oncol2010，49，7： | 1 |
| 9 | Fh3 ligand treatment reverses endotoxin tolerance-related immunoparalysis 显示文摘 | Wysocka M Montaner LJ Karp CL | 2005 | J Immunol2005，174，11： | 1 |
| 10 | IL- 12 is required for natural killer cell activation and subsequent T helper 1 cell development in experiment leishmaniasis显示文摘 | Scharton KT Monso IE Wysocka M | 1995 | J Immunol1995，154，10： | 1 |
| 11 | In vitro effect of quercetin on human gastric carcinoma:targeting cancer cells death and MDR显示文摘 | BORSKA S CHMIELEWSKA M WYSOCKA T | 2012 | Food Chem Toxicol2012，50，： | 1 |
| 12 | Resistance to antigen-induced airway hyperresponsiveness requires endogenous production of IL-12显示文摘 | Keane-Myers A Wysocka M Trinchieri G | 1998 | J Immunol1998，161，2： | 1 |
| 13 | IL-12 suppression during experimental endotoxin tolerance:Dendritic cell loss and macrophage hyporesponsiveness显示文摘 | Wysocka M Robertson S Riemann H | 2001 | J Immunol2001，166，12： | 1 |
| 14 | In vitro effect of quereetin on human gastric carcinoma:Targeting cancer cells death and MDR显示文摘 | Borska S Chmielewska M Wysocka T | 2012 | Food Chem Toxicol2012，50，9： | 1 |
| 15 | Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis 显示文摘 | Wysocka M Montaner L J Karp C L | 2005 | J Immunol2005，174，11： | 1 |
| 16 | The role for interleukin - 12 therapy of cutaneous T cell lymphoma显示文摘 | ROOK A H ZAKI M H WYSOCKA M | 2001 | Ann N Y Acad Sci2001，941，5： | 1 |
| 17 | In the Absence of Endogenous IL-10, Mice Acutely Infected with Toxoplasma Gondii Succumb to a Lethal Immune Respond Dependent on CD+4 T Cells and Accompanied by Overproduction of IL-2, IFN-γand TNF-α 显示文摘 | Wysocka M Hieng S | 1996 | Immunol1996，157，： | 1 |
| 18 | In the absence of endogenous IL-10,mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4^+T cells and accompanied by overproduction of IL-12,IFN -gamma and TNFalpha显示文摘 | Gazzinelli R T Wysocka M Hieny S | 1996 | J Immunol1996，157，： | 1 |
| 19 | In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha显示文摘 | Gazzinelli RT Wysocka M Hieny S | 1996 | J Immunol1996，157，2： | 1 |
| 20 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients 显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，596，： | 1 |
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