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| 1 | 婚姻状况与心血管病风险的关系:系统评价和荟萃分析显示文摘虽然80%的未来心血管病风险可以从已知的心血管危险因素预测,如老年、男性、高血压、高血脂症、吸烟和糖尿病,但其余20%风险的决定因素仍不明确。婚姻对健康和死亡的益处已经在不同种族的两性中得到证实,并且与各种社会人口学特征无关。 | Wong CW Kwok CS Narain A Gulati M Mihalidou AS Wu P Alasnag M Myint PK Mamas MA 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 5 |
| 2 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 3 | Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women显示文摘This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke.Thirty elderly female patients with non-aphasic ischemic stroke aged ≥ 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited.Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex,along with its subdivisions:anterior cingulate cortex,orbitofrontal cortex and dorsolateral prefrontal cortex.The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke.At 3 months poststroke,left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only(partial coefficient = 0.453,P = 0.045),after controlling for age,education,diabetes,neurological deficit,white matter lesions volume,as well as the location and volume of infarcts.At 15 months poststroke,there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.661,P = 0.001) and between the left prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.573,P = 0.004) in female patients after the same adjustments.These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke.Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke. | Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 4 | AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells显示文摘 | Lee CW Wong LL Tse EY | 2012 | Cancer Res2012，72，17： | 1 |
| 5 | Molecular mechanisms ofcytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation 显示文摘 | Cheung PF Wong CK Lam CW | 2008 | J Immtmol2008，180，8： | 1 |
| 6 | Do allelic variants of the connexin37 1019 gene polymoIphism differentially predict for coro- nary artery disease and myocardial infarction? 显示文摘 | Wong CW Christen T Pfenniger A | 2007 | Atherosclero- sis2007，191，2： | 1 |
| 7 | Alzheimer's disease:initial report of the purification and characterization of a novel cerebrovascular amyloid protein显示文摘 | Glenner GG Wong CW | 1984 | Biochem Biophys Res Commun1984，120，： | 1 |
| 8 | Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘 | Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y | | 0，，： | 1 |
| 9 | Alzheimer's disease:initial report of the purification and characterization of a novel cerebrovascu- lar amyloid protein 显示文摘 | Glenner GG Wong CW | 2012 | Biochem Biophys Res Commun2012，425，3： | 1 |
| 10 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein显示文摘 | Wong CW | 1984 | Biochem Biophys Res Commun1984，120，： | 1 |
| 11 | Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods显示文摘 | Wong JM Kendall CW Marchie A | 2012 | Am J Clin Nutr2012，95，3： | 1 |
| 12 | Alzheimer's disease:initial report of the purification and characterization of a novel cerebrovascular amyloid protein显示文摘 | Glenner GG Wong CW | 1984 | Biochem Biophys Res Commun1984，120，3： | 1 |
| 13 | AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells 显示文摘 | Lee CW Wong LL Tse EY | 2012 | Cancer Res2012，72，17： | 1 |
| 14 | Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways 显示文摘 | Ho AW Wong CK Lam CW | 2008 | lmmunobiology2008，213，7： | 1 |
| 15 | Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells显示文摘 | Wong CW Hou PS Tseng SF | 2010 | Stem Cells2010，28，9： | 1 |
| 16 | Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus:implications for Th17-mediated inflammation in auto-immunity显示文摘 | Wong CK Lit LC Tam LS Li EK Wong PT Lam CW | 2008 | Clin Immunol2008，127，3： | 1 |
| 17 | Who Advised the Hong Kong Government? The Politics of Absorption before and after 1997显示文摘 | Cheung Anthony BL Paul CW Wong | | 0，，06： | 1 |
| 18 | Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology ofallergie inflammation 显示文摘 | Wong CK Cheung PF Lam CW | 2007 | Eur J Immunol2007，37，8： | 1 |
| 19 | Cyclooxygenase-2-de- rived prostaglandine F2alpha mediates endothelium-de- pendent contractions in the aortae of hamsters with increased impact during aging 显示文摘 | Wong SL Leung FP Lau CW | 2009 | Circ Res2009，104，2： | 1 |
| 20 | Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-alpha in hypercholesterolemic rats induced with a high-cholesterol diet显示文摘 | Wan CW Wong CN Pin WK | 2013 | Phytother Res2013，27，4： | 1 |
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